In this section, depression in the geriatric population will be discussed. Although depression is a common psychiatric disorder in the geriatric population, approximately 50% of patients remain undiagnosed. In depression in older ages, the mood symptoms of sadness, sadness, and grief may not be prominent. Generalized anxiety, irritability, restlessness, childish behavior, stubbornness, constant complaining, whining, and excessive demandingness are also masked manifestations of depression. In older ages, the rate of spontaneous recovery is low, and the risk of suicide is high. Depression has effects such as causing physical difficulties, developing medical diseases, and increasing mortality. For this reason, early diagnosis and treatment are of great importance. When using psychotropic drugs in elderly patients, appropriate drug selection should be made by taking liver, kidney, or heart dysfunctions into consideration, and concomitantly used drugs should be evaluated.