Release Date: 2024-05-30

Geriatric Depression

Release Date: 2024-05-30

In this section, depression in the geriatric population will be discussed. Although depression is a common psychiatric disorder in the geriatric population, approximately 50% of patients remain undiagnosed. In depression in older ages, the mood symptoms of sadness, sadness, and grief may not be prominent. Generalized anxiety, irritability, restlessness, childish behavior, stubbornness, constant complaining, whining, [...]

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    Work TypeBook Chapter
    Published inDepression Treatment Updates
    First Page177
    Last Page191
    DOIhttps://doi.org/10.69860/nobel.9786053359456.10
    Page Count15
    Copyright HolderNobel Tıp Kitabevleri
    Licensehttps://nobelpub.com/publish-with-us/copyright-and-licensing
    In this section, depression in the geriatric population will be discussed. Although depression is a common psychiatric disorder in the geriatric population, approximately 50% of patients remain undiagnosed. In depression in older ages, the mood symptoms of sadness, sadness, and grief may not be prominent. Generalized anxiety, irritability, restlessness, childish behavior, stubbornness, constant complaining, whining, and excessive demandingness are also masked manifestations of depression. In older ages, the rate of spontaneous recovery is low, and the risk of suicide is high. Depression has effects such as causing physical difficulties, developing medical diseases, and increasing mortality. For this reason, early diagnosis and treatment are of great importance. When using psychotropic drugs in elderly patients, appropriate drug selection should be made by taking liver, kidney, or heart dysfunctions into consideration, and concomitantly used drugs should be evaluated.

    Berna Balikci (Author)
    Research Assistant, Dicle University
    https://orcid.org/0009-0009-2158-7078
    3Dr. Berna Balıkçı studied at Dicle University Faculty of Medicine in 2014-2020. He graduated from Dicle University Faculty of Medicine in 2020 and received the title of Medical Doctor. In 2020-2022, he worked as a general practitioner in the emergency department in the Kozluk district of Batman province, as part of his compulsory service obligation. In July 2022, she started working as a research assistant at Dicle University Faculty of Medicine, Department of Psychiatry, and she still continues this position. She is a member of 2 organizations related to her profession.

    Suleyman Donmezdil (Author)
    Associate Professor, Mardin Artuklu University
    https://orcid.org/0000-0002-7171-1374
    3Associate Professor Süleyman Dönmezdil completed his medical education at Harran University Faculty of Medicine. He completed his specialization training at Dicle University Faculty of Medicine between 2009-2013. In 2018, he started working as an assistant professor at Health Sciences University Gazi Yaşargil Health Practice And Research Center Internal Medical Sciences Department. He has been working as an associate professor at Mardin Artuklu University Faculty of Letters, Department of Psychology, since 2022. Dr. Dönmezdil, who has contributed to the field with many articles, is a member of the Turkish Psychiatric Association.

    • James SL, Abate D, Abate KH, Abay SM, Abbafati C, Abbasi N, et al. Global, regional and national incidence, prevalence and years lived with disability of 354 diseases and injuries in 195 countries and territories, 1990–2017: A systematic analysis for the Global Burden of Disease Study 2017. The Lancet. 2018 ;392 (10159):1789–858..

    • Moss K, Scogin F, Di Napoli E, Presnell A. Self-help behavioral activation therapy for geriatric depressive symptoms. Aging Mental Health. 2012 ;16 (5):625–35

    • Demyttenaere K, Bruffaerts R, Posada-Villa J, Gasquet I, Kovess V, Lepine JP, et al. Prevalence, severity, and unmet treatment need of mental disorders in the World Health Organization World Mental Health Surveys. JAMA. 2004 ;291 (21):2581– 90.

    • Mitchell AJ, Subramaniam H. Prognosis of depression in old age compared to middle age: a systematic review of comparative studies. I’m J Psychiatry. 2005 ;162 (9):1588–601.

    • Patel V, Saxena S. Transforming lives, improving communities – innovations in global mental health. N Engl J Med. 2014 ;370 (6):498–501.

    • Alexopoulos, GS et al. Functional connectivity in the cognitive control network and default mode network in late-life depression. J. Affect. confusion 139, 56–65 (2012).

    • Alexopoulos, GS et al. Microstructural white matter abnormalities and remission of geriatric depression. Am. J. Psychiatry 165, 238–244 (2008)

    • Taylor WD, Aizenstein HJ and Alexopoulos GS The vascular depression hypothesis: mechanisms linking vascular disease to depression. Mole. Psychiatry 18, 963–974 (2013).

    • Alexopoulos, GS et al. The ‘vascular depression’ hypothesis. Arch. Again. Psychiatry 54, 915–922 (1997).

    • Januar, V., Ancelin, ML, Ritchie, K., Saffery, R. & Ryan, J. BDNF promoter methylation and genetic variation in late-life depression. Translation Psychiatry 5, e619 (2015).

    • Miller, AH, Haroon, E., Raison, CL & Felger, JC Cytokine targets in the brain: impact on neurotransmitters and neural circuits. Becoming depressed. Anxiety 30, 297–306 (2013).

    • Hall, BS, Moda, RN and Liston, C. Glucocorticoid mechanisms of functional connectivity changes in stress-related neuropsychiatric disorders. Neurobiol. Stress 1, 174–183 (2015).

    • 14. McEwen, B. Mood disorders and allostatic load. Biol. Psychiatry 54, 200–207 (2003).

    • Alexopoulos, GS “Late-life depression-executive dysfunction syndrome”: A specifictarget for D3 agonists ?Am. J.Geriatrist. Psychiatry 9, 22–29 (2001).

    • Manning, KJ & Steffens, DC State of the science of nervous systems in late-life depression: impact on clinical presentation and treatment outcomes. J. Am. Geriatr. SOS. 66 ( Suppl 1), S17–s23 (2018).

    • Alexopoulos, GS et al. Clinically defined vascular depression. Am. J. psychiatry 154, 562–565 (1997)

    • De la Torre, JC Cerebral hemodynamic and vascular risk factors: predisposing to Alzheimer’s disease. J. Alzheimer’s Disease. 32, 553–567 (2012).

    • Paranthaman, R. et al. The relationship between endothelial function and atherosclerosis and response to treatment in late-life depression. International J. Geriatr. Psychiatry 27, 967–973 (2012).

    • Cole MG. Recurrence of geriatric depression.Am J Psychiatry 2000 ;157:1183 –4.

    • Molnar BE, Buka SL, Kessler RC. Child sexual abuse and subsequent psychopathology: results from the National Comorbidity Survey. Am J Public Health 2001 ;91:753 –60

    • Takeshima M, Kurata K. Late-life bipolar depression due to the mild form of bipolar disorder compared with unipolar depression: An inpatient chart review study. J. Affect. confusion 2010 ; 123:64-70

    • Baba H. Depressive syndrome in late life. In: Medical Syndromes of Psychiatric Illness. Tokyo: Nippon Rinsho, Place of publication, 2017; 540 – 545 (Japanese).

    • Shikawa M, Asada T. Dementia diagnostic strategy and points of differentiation. Yakkyoku2017 ; 68: 2233 – 2239 (in Japanese).

    • Tabuchi H. Depression and frontotemporal dementia. Jpn J. Geriatr. Psychiatry 2018 ; 29: 274 – 280 (in Japanese).

    • Tanaka T, Takeda M. Depression, delirium and dementia. Nihon Rinsho2011 ; 69: 384 – 389 (in Japanese).

    • Hegeman JM, Kok RM, van der Mast RC, Giltay EJ. Phenomenology of depression in older people compared with young adults: Meta-analysis. br. J. Psychiatry 2012 ;200 : 275 – 281.

    • Maj M, Pirozzi R, Magliano L, Fiorillo A, Bartoli L. Phenomenology and prognostic significance of delusions in major depressive disorder: a 10-year prospective follow-up study. J. Clin. Psychiatry 2007 ; 68: 1411 – 1417.

    • Nelson JC, Delucchi K, Schneider LS. Moderators of outcomes in late-life depression: A patient-level meta- analysis. Am. J. Psychiatry 2013 ; 170: 651 – 659.

    • Wilkinson P, Izmeth Z. Continuation and maintenance treatments for depression in the elderly. Cochrane Database Syst. Rev. 2016 ;9 : CD006727.

    • Nelson JC Management of Later Life Depression. Handb. Experience. Pharmacol. 2019 ;250 : 389 – 413.

    • Mutschler E, Geisslinger G, Kroemer HK, Menzel S, Ruth P. Wissenschaftliche Verlagsgesellschaft. 10. Stuttgart: 2012. Arzneimittelwirkungen: Pharmakologie - Klinic Pharmakologie - Toxikologie.

    • Kennedy SH, Lam RW, McIntyre RS and others. Canadian network of mood and anxiety treatments (CANMAT) 2016 clinical guidelines for the Management of Adults with major depressive disorder: Part 3. Pharmacological treatments. To be. J. Psychiatry 2016 ; 61: 540 – 560.

    • Alexopoulos GS Katz IR Reynolds CF Carpenter D Docherty JP Expert consensus guideline series: pharmacotherapy of depressive disorders in elderly patients.

    • Bauer M, Adli M, Ricken R, Severus E, Pilhatsch M. The role of lithium supplementation in the treatment of major depressive disorder. Central Nervous System Drugs. 2014 ;

    • Grandjean EM, Aubry JM. Lithium: updated human knowledge using an evidencebased approach: partIII : clinical safety. Central Nervous System Drugs. 2009a ; 23: 397-418.

    • Lenze EJ, Mulsant BH, Blumberger DM, et al. Efficacy, safety, and tolerability of augmentation pharmacotherapy with aripiprazole for treatment-resistant depression in late life: a randomized, double-blind, placebo-controlled study. Lancet 2015; 386:2404–12.

    • Alexopoulos, GS, Katz, IR, Reynolds, CF, 3rd, Carpenter, D., Docherty, JP Expert consensus guideline series. Pharmacotherapy of depressive disorders in elderly patients.

    • Cuijpers P, van Straten A, Smit F. Psychological treatment of late-life depression: A meta-analysis of randomized controlled trials. International J. Geriatr. Psychiatry 2006 ;21 : 1139 – 1149.(33) Soh JF, Klil-Drori S, Rej S. Lithium use in senile bipolar disorder: Special considerations. Aging Drugs 2019 ; 36: 147-154.

    • De Maat S, Dekker J, Schoevers RA, de Jonghe F. Relative effectiveness of psychotherapy and combination therapy in treating depression: A meta-analysis. psychologist Bastard. 2006 ; 16: 566 – 578.

    • Sexton CE, Mackay CE, Ebmeier KP. A systematic review and meta-analysis of magnetic resonance imaging studies in late-life depression. Ben J Geriatr Psychiatry. 2013; 21(2):184–95

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