Release Date: 2024-06-12

Immunotherapy in Hematological Malignancy

Sehmus Ertop (Author), Hatice Ayag (Author), Muzeyyen Aslaner Ak (Author), Birsen Sahip Yesiralioglu (Author)

Release Date: 2024-06-12

Tumor immune tolerance represents a significant obstacle to effective cancer therapy. A multitude of pathways through which tumors evade immune surveillance have been identified . These developments have prompted a reevaluation of the "hallmarks of cancer" and have spurred the development of numerous promising immunotherapies. Various categories of immunotherapies, including stem cell transplantation, immune checkpoint [...]

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    Work TypeBook Chapter
    Published inImmunotherapy in Human Cancers
    First Page33
    Last Page48
    DOIhttps://doi.org/10.69860/nobel.9786053359388.4
    Page Count16
    Copyright HolderNobel Tıp Kitabevleri
    Licensehttps://nobelpub.com/publish-with-us/copyright-and-licensing

    Tumor immune tolerance represents a significant obstacle to effective cancer therapy. A multitude of pathways through which tumors evade immune surveillance have been identified . These developments have prompted a reevaluation of the "hallmarks of cancer" and have spurred the development of numerous promising immunotherapies. Various categories of immunotherapies, including stem cell transplantation, immune checkpoint inhibitors, antigen-targeted antibodies, antibody-drug conjugates, tumor vaccines, and adoptive cell therapies, have been devised for treating hematologic cancers, with ongoing clinical trials. These immunotherapies demonstrate potential for inducing long-term remissions in patients with refractory or relapsed disease, marking a paradigm shift in cancer treatment with significant clinical success. Here, we review recent advances in understanding these categories of immunotherapies for hematologic malignancies.

    Sehmus Ertop (Author)
    MD, Professor, Bülent Ecevit University
    https://orcid.org/0000-0001-8771-7343
    3Şehmus Ertop student in Dicle University Medicine Faculty 1988, Internal medicine specialist in Dicle Medicine Faculty 1992, hematology specialist in Dicle University 1992, from 2011 until now she is Prof. in ZBEU.

    Hatice Ayag (Author)
    Assistant Professor, Bülent Ecevit University
    https://orcid.org/0009-0000-3228-451X
    3Hatice Ayağ, student in Dicle University Medicine Faculty 2004, Internal medicine specialist in Dicle Medicine Faculty 2011, hematology specialist in ZBEU 2024.

    Muzeyyen Aslaner Ak (Author)
    MD, Assoc. Prof., Bülent Ecevit University
    https://orcid.org/0000-0001-6621-3138
    3Muzeyyen Aslaner educated in Dokuz Eylül University Medicine Faculty 2000, Internal medicine specialist in Istanbul Trainin hospital 2009, hematology specialist in ZBEU University 2016, from 2016 until now she is Assoc Prof. in ZBEU.

    Birsen Sahip Yesiralioglu (Author)
    MD, Assistant Professor, Bülent Ecevit University
    https://orcid.org/0000-0001-5375-6432
    3Birsen Sahip Yesiralioğlu, student in Ataturk University Medicine Faculty 2006, Internal medicine specialist in Trakya Medicine Faculty 2015, hematology specialist in Zonguldak Bulent Ecevit University 2021, from 2023 until now she is Asist Prof. in ZBEU.

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