Release Date: 2024-06-12

Immunotherapy in Gastro-Esophageal Cancers

Yasin Sezgin (Author), Mahmut Kara (Author)

Release Date: 2024-06-12

Cancers of the gastro-oesophageal system represent the fourth most common cancer type, following lung and breast cancers. Mortality rates remain high due to late diagnosis. In the context of gastrointestinal malignancies, the tumour microenvironment and immune system play a pivotal role in cancer progression and treatment response. The role of immunotherapy in the treatment of [...]

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    Work TypeBook Chapter
    Published inImmunotherapy in Human Cancers
    First Page205
    Last Page218
    DOIhttps://doi.org/10.69860/nobel.9786053359388.14
    Page Count14
    Copyright HolderNobel Tıp Kitabevleri
    Licensehttps://nobelpub.com/publish-with-us/copyright-and-licensing
    Cancers of the gastro-oesophageal system represent the fourth most common cancer type, following lung and breast cancers. Mortality rates remain high due to late diagnosis. In the context of gastrointestinal malignancies, the tumour microenvironment and immune system play a pivotal role in cancer progression and treatment response. The role of immunotherapy in the treatment of gastroesophageal cancers has become increasingly significant in recent years. Immunotherapy, which was previously employed solely in the context of metastatic gastric cancer, has recently been established as a standard treatment modality in the adjuvant management of oesophageal cancer that has undergone neoadjuvant therapy and remains following surgical resection. Furthermore, studies are currently underway to assess the efficacy of combining immunotherapy with standard chemotherapy regimens in the neoadjuvant treatment of gastric cancer. Preclinical and clinical evidence has demonstrated the effectiveness of anti-PD1 and anti-PDL1 agents in gastroesophageal cancers, and these agents are now included in current guidelines. In addition to these agents, studies are ongoing to evaluate the potential of CTLA-4 inhibitors and vaccines in this setting.

    Yasin Sezgin (Author)
    Assistant Professor, Van Yuzuncu Yil University
    https://orcid.org/0000-0003-4122-8389
    3Education Status: 2008 Yüzüncü Yıl University Faculty of Medicine 2012-2016 Yüzüncü Yıl University Internal Medicine 2018-2021 Dicle University Faculty of Medicine Medical Oncology Organisations Worked For: 2008-2012 General practitioner Batman Kozluk State Hospital 2012-2016 Assistant physician Yüzüncü Yıl University Faculty of Medicine, Department of Internal Medicine 2016-2017 Specialist physician Van Özalp State Hospital 2018-2021 Minor assistant Dicle University Faculty of Medicine 2021-2023 Specialist physician Siirt Training and Research Hospital 2023-Present Dr. Lecturer Yüzüncü Yıl University Faculty of Medicine Medical Oncology Clinic

    Mahmut Kara (Author)
    MD, Professor of Internal Medicine, Van Yuzuncu Yil University

    3Mahmut KARA Current Position: Yüzüncü Yıl University Faculty of Medicine, Department of Medical Oncology Education Status: 2015 Sivas Cumhurriyet University Faculty of Medicine 2020 Malatya Turgut Özal University Internal Medicine 2023 Yüzüncü Yıl University Faculty of Medicine Medical Oncology Organisations Worked For: 2016 General practitioner adıyaman State Hospital 2016- 2020 Assistant physician Yüzüncü Yıl University Malatya Turgut Özal University Internal Medicine 2020-2022 Specialist physician Van Bahçesaray State Hospital 2022-Present Minor assistant Yüzüncü Yıl University Faculty of Medicine Medical Oncology Clinic

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