Grape seeds (GS) are waste products from the manufacturing of wine, molasses, and fruit juice. They are the portion of grapes that have the highest concentration of phenolic and antioxidant chemicals, second only to the fruits. In addition to highly polymerized procyanidins, the GS contains catechin, epicatechin, gallocatechin, epigallocatechin, and gallic acid. GS may be a good substitute for being used in the creation of new goods with a high added value, such as antioxidant-rich smart foods that are extremely concentrated. Because of its strong antioxidant, anticancer, antibacterial, anti-aging, antidiabetic and anti-inflammatory properties, grape seed extracts (GSE) is frequently used as a dietary supplement and is generally considered safe. Analysis of grape cultivars’ seeds, pulp, and peel revealed that the seeds’ capacity to scavenge DPPH was noticeably greater than that of the peels and pulpsnnGrape seed is effective against common metabolic diseases such as diabetes, Alzheimer’s disease, cancer, hypertension, and microbial pathogens, as proven by in vitro and in vivo experiments, due to the antioxidant molecules it contains. It is responding to a growing consumer demand to replace other synthetic antioxidants in fortifying and extending the shelf life of many foods, such as cheese, milk, and meat. Grape seeds are a natural antioxidant source of functional foods, food additives and pharmacological compounds with their rich bioactive molecule content.