Neurological diseases have a very serious impact on humanity. Major diseases such as Alzheimer’s, Parkinson’s, Multiple Sclerosis, Epilepsy, Brain tumors, stroke, and Amyotrophic Lateral Sclerosis change the lives of many people significantly. Some of these diseases still do not have a complete treatment method. Enzymes take part in many biological reactions as biological catalysts and are effective in the treatment and occurrence of diseases. Important enzymes are used in the treatment of neurological diseases. In this chapter, some important neurological diseases and the enzymes used in the treatment of these diseases are described.