Release Date: 2024-06-10

Role of Some Enzymes in Neurological Diseases

Ebubekir Izol (Author)

Release Date: 2024-06-10

Neurological diseases have a very serious impact on humanity. Major diseases such as Alzheimer’s, Parkinson’s, Multiple Sclerosis, Epilepsy, Brain tumors, stroke, and Amyotrophic Lateral Sclerosis change the lives of many people significantly. Some of these diseases still do not have a complete treatment method. Enzymes take part in many biological reactions as biological catalysts and [...]

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    Work TypeBook Chapter
    Published inNeurological Diseases and Treatments in Terms of Biochemistry
    First Page17
    Last Page36
    DOIhttps://doi.org/10.69860/nobel.9786053359357.2
    Page Count20
    Copyright HolderNobel Tıp Kitabevleri
    Licensehttps://nobelpub.com/publish-with-us/copyright-and-licensing

    Neurological diseases have a very serious impact on humanity. Major diseases such as Alzheimer’s, Parkinson’s, Multiple Sclerosis, Epilepsy, Brain tumors, stroke, and Amyotrophic Lateral Sclerosis change the lives of many people significantly. Some of these diseases still do not have a complete treatment method. Enzymes take part in many biological reactions as biological catalysts and are effective in the treatment and occurrence of diseases. Important enzymes are used in the treatment of neurological diseases. In this chapter, some important neurological diseases and the enzymes used in the treatment of these diseases are described.

    Ebubekir Izol (Author)
    Bingöl University
    https://orcid.org/0000-0003-0788-4999
    3Dr. Ebubekir İZOL, Atatürk University, received his PhD degree in the Department of Biochemistry. He has many international scientific studies in the field of biochemistry. He focused on antioxidants, enzymes, minerals, and carbohydrate metabolism. He has conducted enzyme inhibition studies on Alzheimer’s, diabetes, glaucoma, and epilepsy diseases. He is involved in many scientific study projects.

    • Izol, E. 2016. Determination of Heavy Metals and Seconder Metabolites of some Allium (Wild Garlic) Species by ICP-MS and LC-MS/ MS Investigation of Their Biological Activities. Dicle Üniversitesi, Fen Bil. Ens., Kimya ABD, Yüksek Lisans Tezi.

    • İzol, E. (2023). Bazı Arı Ürünlerinin (Bal, Polen, Propolis, Arı Sütü ve Arı Ekmeği) LC-MS/MS ile Sekonder Metabolitlerinin ve Biyolojik Aktivitelerinin Belirlenmesi. Doktora tezi. Atatürk Üniversitesi Fen Bilimleri Enstitüsü, Erzurum.

    • Wirth, R., Dziewas, R., Beck, A. M., Clave, P., Hamdy, S., Heppner, H. J., ... & Volkert, D. (2016). Oropharyngeal dysphagia in older persons–from pathophysiology to adequate intervention: a review and summary of an international expert meeting. Clinical interventions in aging, 189-208.

    • Rafiq, M. K., Lee, E., Bradburn, M., McDermott, C. J., & Shaw, P. J. (2015). Effect of lipid profile on prognosis in the patients with amyotrophic lateral sclerosis: insights from the olesoxime clinical trial. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 16(7-8), 478-484.

    • Tekeli, H., & Şenol, M. (2013). Nörolojik hastalıklar ve yanlış uygulamalar. Turkiye Klinikleri J Fam Med-Special Topics, 4(3), 45-6.

    • Cho, S., & Chu, M. K. (2024). Headache in Brain Tumors. Neurologic Clinics.

    • Baker, S., Auld, G., Ammerman, A., Lohse, B., Serrano, E., & Wardlaw, M. K. (2020). Identification of a framework for best practices in nutrition education for low-income audiences. Journal of nutrition education and behavior, 52(5), 546-552.

    • Dziewas, R., Beck, A. M., Clave, P., Hamdy, S., Heppner, H. J., Langmore, S. E., ... & Wirth, R. (2017). Recognizing the importance of dysphagia: stumbling blocks and stepping stones in the twenty-first century. Dysphagia, 32, 78-82.

    • Çavdarlı, B. (2023). Huntington Hastalığına Genetik Yaklaşım. Turkiye Klinikleri Medical Genetics-Special Topics, 8(2), 48-54.

    • Yapıcı, İ., İzol, E., Gülçin, İ. (2023). “The Role of Enzymes in Honey Quality”, In Safety of Bee Products, ed. İzol E., Haspolat Y.K., Orient Publications, 1-9.

    • İzol, E., Yapıcı, İ., (2023). “Effect of α-Glucosidase and α-Amylase Enzymes on Diabetes”, In 6. International Marmara Scientific Research and Innovation Congress Book p:234-241, ISBN: 978-625-367-375-8. October 07-08, İstanbul, Türkiye

    • Yapıcı, İ., İzol, E., (2023). “Effects of Acetylcholinesterase and Butyrylcholinesterase Enzymes on Human Memory” In 6. International Marmara Scientific Research and Innovation Congress Book p:242-249, ISBN: 978-625-367-375-8. October 07-08, İstanbul, Türkiye.

    • Kuchay, R. A. H. (2020). New insights into the molecular basis of lactase non-persistence/persistence: A brief review. Drug Discoveries & Therapeutics, 14(1), 1-7.

    • Farooqui, A. A., Litsky, M. L., Farooqui, T., & Horrocks, L. A. (1999). Inhibitors of intracellular phospholipase A2 activity: their neurochemical effects and therapeutical importance for neurological disorders. Brain research bulletin, 49(3), 139-153.

    • Wang, B. (2021). The acute hepatic porphyrias. Translational Gastroenterology and Hepatology, 6.

    • Galasso, M., Gambino, S., Romanelli, M. G., Donadelli, M., & Scupoli, M. T. (2021). Browsing the oldest antioxidant enzyme: catalase and its multiple regulation in cancer. Free Radical Biology and Medicine, 172, 264-272.

    • Obaid, R. J., Mughal, E. U., Naeem, N., Sadiq, A., Alsantali, R. I., Jassas, R. S., ... & Ahmed, S. A. (2021). Natural and synthetic flavonoid derivatives as new potential tyrosinase inhibitors: A systematic review. RSC advances, 11(36), 22159-22198.

    • Kumar, A., Dhull, D. K., Gupta, V., Channana, P., Singh, A., Bhardwaj, M., ... & Mittal, R. (2017). Role of Glutathione-S-transferases in neurological problems. Expert Opinion on Therapeutic Patents, 27(3), 299-309.

    • Bagheri, S., Haddadi, R., Saki, S., Kourosh-Arami, M., Rashno, M., Mojaver, A., & Komaki, A. (2023). Neuroprotective effects of coenzyme Q10 on neurological diseases: A review article. Frontiers in Neuroscience, 17, 1188839.

    • Self, W. K., & Holtzman, D. M. (2023). Emerging diagnostics and therapeutics for Alzheimer disease. Nature medicine, 29(9), 2187-2199.

    • Rao, C. V., Asch, A. S., Carr, D. J., & Yamada, H. Y. (2020). “Amyloid‐beta accumulation cycle” as a prevention and/or therapy target for Alzheimer's disease. Aging Cell, 19(3), e13109.

    • McGeer, E. G., & Singh, E. A. (1992). Angiotensin-converting enzyme in cortical tissue in Alzheimer's and some other neurological diseases. Dementia and Geriatric Cognitive Disorders, 3(5-6), 299-303

    • Yang, X., Dai, G., Li, G., & Yang, E. S. (2010). Coenzyme Q10 reduces β-amyloid plaque in an APP/PS1 transgenic mouse model of Alzheimer’s disease. Journal of molecular neuroscience, 41, 110-113.

    • Izol, E., Temel, H., Yilmaz, M. A., Yener, I., Olmez, O. T., Kaplaner, E., ... &Ertas, A. (2021). A detailed chemical and biological investigation of twelve Allium species from Eastern Anatolia withchemometric studies. Chemistry&Biodiversity, 18(1), e2000560.

    • Bursal, E., Yılmaz, M. A., Izol, E., Türkan, F., Atalar, M. N., Murahari, M., ... &Ahmad, M. (2021). Enzyme inhibitory function and phytochemical profile of Inula discoidea using in vitro and in silico methods. Biophysical Chemistry, 277, 106629.

    • Karageçili, H., İzol, E., Kireçci, E. & Gülçin, İ. (2023). Antioxidant, antidiabetic, antiglaucoma, and anticholinergic effects of Tayfi grape (Vitis vinifera): A phytochemical screening by LC-MS/MS analysis. Open Chemistry, 21(1), 20230120.

    • Yılmaz, M.A., Cakir, O., İzol, E., Tarhan, A., Behçet, L., Zengin, G. (2023). Detailed Phytochemical Evaluation of a Locally Endemic Species (Campanula baskilensis) by LC-MS/MS and its In-Depth Antioxidant and Enzyme Inhibitory Activities. Chemistry&Biodiversity, 20(12), e202301182.

    • Inci, H., Izol, E., Yilmaz, M. A., Ilkaya, M., Bingöl, Z., & Gülçin, I. (2023). Comprehensive Phytochemical Content by LC/MS/MS and Anticholinergic, Antiglaucoma, Antiepilepsy, and Antioxidant Activity of Apilarnil (Drone Larvae). Chemistry & Biodiversity, 20(10), e202300654.

    • Karagecili, H., Izol, E., Kirecci, E., Gulcin, I. (2023). Determination of Antioxidant, Anti-Alzheimer, Antidiabetic, Antiglaucoma and Antimicrobial Effects of Zivzik Pomegranate (Punicagranatum) —A Chemical Profiling by LC-MS/MS). Life, 13, 735.

    • Bischoff, S. C., Singer, P., Koller, M., Barazzoni, R., Cederholm, T., & Van Gossum, A. (2015). Standard operating procedures for ESPEN guidelines and consensus papers. Clinical Nutrition, 34(6), 1043-1051.

    • Tan, Y. Y., Jenner, P., & Chen, S. D. (2022). Monoamine oxidase-B inhibitors for the treatment of Parkinson’s disease: past, present, and future. Journal of Parkinson's Disease, 12(2), 477-493.

    • Salamon, A., Zádori, D., Szpisjak, L., Klivényi, P., & Vécsei, L. (2022). What is the impact of catechol-O-methyltransferase (COMT) on Parkinson’s disease treatment? Expert Opinion on Pharmacotherapy, 23(10), 1123-1128.

    • Turkistani, A., Al-Kuraishy, H. M., Al-Gareeb, A. I., Albuhadily, A. K., Alexiou, A., Papadakis, M., ... & Batiha, G. E. S. (2024). Therapeutic Potential Effect of Glycogen Synthase Kinase 3 Beta (GSK-3β) Inhibitors in Parkinson Disease: Exploring an Overlooked Avenue. Molecular Neurobiology, 1-17.

    • Rausch, W. D., Wang, F., & Radad, K. (2022). From the tyrosine hydroxylase hypothesis of Parkinson’s disease to modern strategies: a short historical overview. Journal of Neural Transmission, 129(5), 487-495.

    • Picache, J. A., Zheng, W., & Chen, C. Z. (2022). Therapeutic strategies for Tay-Sachs disease. Frontiers in Pharmacology, 13, 906647.

    • Shaimardanova, A. A., Chulpanova, D. S., Solovyeva, V. V., Aimaletdinov, A. M., & Rizvanov, A. A. (2022). Functionality of a bicistronic construction containing HEXA and HEXB genes encoding β-hexosaminidase A for cell-mediated therapy of GM2 gangliosidoses. Neural Regeneration Research, 17(1), 122-129.

    • Michie, S., West, R., Sheals, K., & Godinho, C. A. (2018). Evaluating the effectiveness of behavior change techniques in health-related behavior: a scoping review of methods used. Translational behavioral medicine, 8(2), 212-224.

    • Masrori, P., & Van Damme, P. (2020). Amyotrophic lateral sclerosis: a clinical review. European journal of neurology, 27(10), 1918-1929.

    • Tabrizi, S. J., Estevez-Fraga, C., van Roon-Mom, W. M., Flower, M. D., Scahill, R. I., Wild, E. J., ... & Leavitt, B. R. (2022). Potential disease-modifying therapies for Huntington's disease: lessons learned and future opportunities. The Lancet Neurology, 21(7), 645-658.

    • Stoker, T. B., Mason, S. L., Greenland, J. C., Holden, S. T., Santini, H., & Barker, R. A. (2022). Huntington’s disease: Diagnosis and management. Practical neurology, 22(1), 32-41.

    • Milligan, T. A. (2021). Epilepsy: a clinical overview. The American Journal of Medicine, 134(7), 840-847.

    • Falco-Walter, J. (2020, December). Epilepsy—definition, classification, pathophysiology, and epidemiology. In Seminars in neurology (Vol. 40, No. 06, pp. 617-623). Thieme Medical Publishers, Inc.

    • Kanner, A. M., & Bicchi, M. M. (2022). Antiseizure medications for adults with epilepsy: a review. Jama, 327(13), 1269-1281.

    • Murimi, M. W., Kanyi, M., Mupfudze, T., Amin, M. R., Mbogori, T., & Aldubayan, K. (2017). Factors influencing efficacy of nutrition education interventions: a systematic review. Journal of nutrition education and behavior, 49(2), 142-165.

    • Liu, X., Han, K., & Lu, X. (2022). Stroke-mimicking unilateral hypokalemic paralysis and literature review. The American Journal of Emergency Medicine, 58, 349-e1.

    • Wang, R., Xie, R., Hu, J., Wu, Q., Rao, W., & Huang, C. (2020). Different acupuncture therapies for spastic paralysis after stroke: a protocol for systematic review and network meta-analysis. Medicine, 99(27), e20974.

    • McGinley, M. P., Goldschmidt, C. H., & Rae-Grant, A. D. (2021). Diagnosis and treatment of multiple sclerosis: a review. Jama, 325(8), 765-779.

    • Schreibelt, G., Van Horssen, J., Van Rossum, S., Dijkstra, C. D., Drukarch, B., & de Vries, H. E. (2007). Therapeutic potential and biological role of endogenous antioxidant enzymes in multiple sclerosis pathology. Brain research reviews, 56(2), 322-330.

    • Sindhu, R. K., Kaur, P., Kaur, P., Singh, H., Batiha, G. E. S., & Verma, I. (2022). Exploring multifunctional antioxidants as potential agents for management of neurological disorders. Environmental Science and Pollution Research, 29(17), 24458-24477.

    • Hauser, S. L., & Cree, B. A. (2020). Treatment of multiple sclerosis: a review. The American journal of medicine, 133(12), 1380-1390.

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