Release Date: 2024-06-19

Role of Metastasectomy in Prostate Cancer Patients Following Curative Treatment

Ahmet Keles (Author), Burak Tufekci (Author)

Release Date: 2024-06-19

Chronic alcohol use profoundly impacts psychological health, often leading to severe mental health issues such as depression, anxiety, and heightened impulsivity. This cycle of dependency and psychological deterioration can significantly impair an individual's quality of life, making it crucial to recognize early symptoms for timely and effective intervention. The discussion extends to the broader implications [...]

Media Type
    Buy from

    Price may vary by retailers

    Work TypeBook Chapter
    Published inCurrent Management of Metastatic Prostate Cancer
    First Page45
    Last Page54
    DOIhttps://doi.org/10.69860/nobel.9786053359142.4
    Page Count10
    Copyright HolderNobel Tıp Kitabevleri
    Licensehttps://nobelpub.com/publish-with-us/copyright-and-licensing

    In this section, we explore the outcomes of metastasectomy in prostate cancer patients. Systemic treatments for low-volume metastatic prostate cancer often lead to various side effects. However, in carefully selected cases, direct treatment methods such as metastasectomy or stereotactic body radiotherapy (SBRT) are used to control the disease in its early stages, providing an alternative to systemic treatments. Metastasectomy is particularly preferred for isolated metachronous metastases identified by PSMA PET scans.

    Ahmet Keles (Author)
    MD, Istanbul Medeniyet University
    https://orcid.org/0000-0001-5436-1803
    3Dr. Ahmet Keles earned his Doctor of Medicine (MD) degree from Akdeniz University School of Medicine and completed his residency in residency in the Department of Urology at Marmara University Faculty of Medicine. During his residency, he achieved certification in European Basic Laparoscopic Urological Skills (E-BLUS) and became a Fellow of the European Board of Urology (FEBU). To further specialize, Dr. Keles underwent rigorous endourology training under Prof. Dr. Jean de la Rosette at Amsterdam Academic Medical Center (AMC) through the prestigious European Urological Scholarship Programme (EUSP). Currently, he is expanding his expertise as a Urologist at Istanbul Medeniyet University Faculty of Medicine. Dr. Keles’s research has resulted in nearly 30 scientific publications in peer-reviewed journals and numerous presentations at national and international conferences. Additionally, he has contributed to the field by authoring six book chapters in urology and oncology. He is also a member of the European Association of Urology (EAU) and the American Urological Association (AUA).

    Burak Tufekci (Author)
    MD, Istanbul Medeniyet University
    https://orcid.org/0000-0002-7029-0109
    3Burak Tüfekci , urology at Istanbul Medeniyet University. He completed his medical education at Istanbul University, Istanbul Medical Faculty, from 2013 to 2019. From 2019 to 2020, he worked at Bigadiç State Hospital in emergency service.Then, he continued his urology resident at Istanbul Medeniyet Univercity since 2020.His areas of interest include urological oncology and kidney stones. He participated in many international and national articles and studies.

    • Connor MJ, Smith A, Miah S, Shah TT, Winkler M, Khoo V, et al. Targeting Oligometastasis with Stereotactic Ablative Radiation Therapy or Surgery in Metastatic Hormone-sensitive Prostate Cancer: A Systematic Review of Prospective Clinical Trials. European Urology Oncology. 2020 Oct 1;3(5):582–93.

    • Kadeerhan G, Xue B, Wu XL, Chen WN, Wang DW. Incidence trends and survival of metastatic prostate cancer with bone and visceral involvement: 2010-2019 surveillance, epidemiology, and end results. Front Oncol [Internet]. 2023 Aug 3 [cited 2024 May 9];13. Available from: https://www.frontiersin.org/journals/oncology/articles/10.3389/ fonc.2023.1201753/full

    • Ost P, Reynders D, Decaestecker K, Fonteyne V, Lumen N, De Bruycker A, et al. Surveillance or Metastasis-Directed Therapy for Oligometastatic Prostate Cancer Recurrence: A Prospective, Randomized, Multicenter Phase II Trial. J Clin Oncol. 2018 Feb 10;36(5):446–53.

    • Kane CJ, Amling CL, Johnstone PAS, Pak N, Lance RS, Thrasher JB, et al. Limited value of bone scintigraphy and computed tomography in assessing biochemical failure after radical prostatectomy. Urology. 2003 Mar;61(3):607–11.

    • Sabbagh A, Mohamad O, Lichter KE, Hope TA. Management of Patients with Recurrent and Metachronous Oligometastatic Prostate Cancer in the Era of PSMA PET. Cancers (Basel). 2022 Dec 15;14(24):6194.

    • Farolfi A, Hadaschik B, Hamdy FC, Herrmann K, Hofman MS, Murphy DG, et al. Positron Emission Tomography and Whole-body Magnetic Resonance Imaging for Metastasis-directed Therapy in Hormone-sensitive Oligometastatic Prostate Cancer After Primary Radical Treatment: A Systematic Review. Eur Urol Oncol. 2021 Oct;4(5):714–30.

    • Calais J, Czernin J, Cao M, Kishan AU, Hegde JV, Shaverdian N, et al. 68Ga-PSMA-11 PET/CT Mapping of Prostate Cancer Biochemical Recurrence After Radical Prostatectomy in 270 Patients with a PSA Level of Less Than 1.0 ng/mL: Impact on Salvage Radiotherapy Planning. J Nucl Med. 2018 Feb;59(2):230–7.

    • Deek MP, Van der Eecken K, Sutera P, Deek RA, Fonteyne V, Mendes AA, et al. LongTerm Outcomes and Genetic Predictors of Response to Metastasis-Directed Therapy Versus Observation in Oligometastatic Prostate Cancer: Analysis of STOMP and ORIOLE Trials. JCO. 2022 Oct 10;40(29):3377–82.

    • Grubmüller B, Baltzer P, D’Andrea D, Korn S, Haug AR, Hacker M, et al. 68Ga-PSMA 11 ligand PET imaging in patients with biochemical recurrence after radical prostatectomy - diagnostic performance and impact on therapeutic decision-making. Eur J Nucl Med Mol Imaging. 2018 Feb;45(2):235–42.

    • Battaglia A, Devos G, Decaestecker K, Witters M, Moris L, Van den Broeck T, et al. Metastasectomy for visceral and skeletal oligorecurrent prostate cancer. World J Urol. 2019 Aug 1;37(8):1543–9.

    • Ploussard G, Gandaglia G, Borgmann H, de Visschere P, Heidegger I, Kretschmer A, et al. Salvage Lymph Node Dissection for Nodal Recurrent Prostate Cancer: A Systematic Review. Eur Urol. 2019 Oct;76(4):493–504.

    • Herlemann A, Kretschmer A, Buchner A, Karl A, Tritschler S, El-Malazi L, et al. Salvage lymph node dissection after 68Ga-PSMA or 18F-FEC PET/CT for nodal recurrence in prostate cancer patients. Oncotarget. 2017 Oct 13;8(48):84180–92.

    • Montorsi F, Gandaglia G, Fossati N, Suardi N, Pultrone C, De Groote R, et al. Robot-assisted Salvage Lymph Node Dissection for Clinically Recurrent Prostate Cancer. Eur Urol. 2017 Sep;72(3):432–8.

    • Weiss RJ, Forsberg JA, Wedin R. Surgery of skeletal metastases in 306 patients with prostate cancer. Acta Orthop. 2012 Feb;83(1):74–9.

    • Rajwa P, Yanagisawa T, Gruber M, Heidenreich A, Joniau S, Briganti A, et al. Surgical Metastasectomy for Visceral and Bone Prostate Cancer Metastases: A Mini-Review. Eur Urol Focus. 2023 Mar;9(2):232–5.

    • Wang H, Li B, Zhang P, Yao Y, Chang J. Clinical characteristics and prognostic factors of prostate cancer with liver metastases. Tumour Biol. 2014 Jan;35(1):595–601.

    • Saitoh H, Hida M, Shimbo T, Nakamura K, Yamagata J, Satoh T. Metastatic patterns of prostatic cancer. Correlation between sites and number of organs involved. Cancer. 1984 Dec 15;54(12):3078–84.

    • Ciriaco P, Briganti A, Bernabei A, Gandaglia G, Carretta A, Viola C, et al. Safety and Early Oncologic Outcomes of Lung Resection in Patients with Isolated Pulmonary Recurrent Prostate Cancer: A Single-center Experience. Eur Urol. 2019 May;75(5):871–4.

    • Kokkalis A, Samara AA, Papadopoulos V, Tolia M, Tsoukalas N, Tsapakidis K. Metachronous Single Pulmonary Metastasis of Prostate Cancer: Report of a Rare Case and Literature Review. Cancer Diagn Progn. 2023;3(2):157–62.

    • Howard DE, Hicks WK, Scheldrup EW. Carcinoma of the prostate with simultaneous bilateral testicular metastases: case report with special study of routes of metastases. J Urol. 1957 Jul;78(1):58–64.

    • Patel SR, Richardson RL, Kvols L. Metastatic cancer to the testes: a report of 20 cases and review of the literature. J Urol. 1989 Oct;142(4):1003–5.

    • Bubendorf L, Schöpfer A, Wagner U, Sauter G, Moch H, Willi N, et al. Metastatic patterns of prostate cancer: an autopsy study of 1,589 patients. Hum Pathol. 2000 May;31(5):578–83.

    • Campara Z, Simic D, Aleksic P, Spasic A, Milicevic S. Metastasis of Prostate Adenocarcinoma to the Testis. Med Arch. 2016 Jul 27;70(4):318–20.

    • Gibas A, Sieczkowski M, Biernat W, Matuszewski M. Isolated Testicular Metastasis of Prostate Cancer after Radical Prostatectomy: Case Report and Literature Review. Urol Int. 2015;95(4):483–5.

    onix_3.0::thothThoth ONIX 3.0
    onix_3.0::project_museProject MUSE ONIX 3.0
    onix_3.0::oapenOAPEN ONIX 3.0
    onix_3.0::jstorJSTOR ONIX 3.0
    onix_3.0::google_booksGoogle Books ONIX 3.0
    onix_3.0::overdriveOverDrive ONIX 3.0
    onix_2.1::ebsco_hostEBSCO Host ONIX 2.1
    csv::thothThoth CSV
    json::thothThoth JSON
    kbart::oclcOCLC KBART
    bibtex::thothThoth BibTeX
    doideposit::crossrefCrossRef DOI deposit
    onix_2.1::proquest_ebraryProQuest Ebrary ONIX 2.1
    marc21record::thothThoth MARC 21 Record
    marc21markup::thothThoth MARC 21 Markup
    marc21xml::thothThoth MARC 21 XML

    Share This Chapter!