Release Date: 2023-09-14

Histopathological Changes in Diabetic Pancreas

Aysenur Kaya (Author), Murat Cetin Ragbetli (Author)

Release Date: 2023-09-14

Histopathological changes in the diabetic pancreas are characterized by several key alterations that impact its structure and function. In type 1 diabetes mellitus (T1DM), autoimmune destruction of insulin-producing beta cells within the pancreatic islets results in their selective loss, termed insulitis. This process involves infiltration of immune cells such as T lymphocytes and macrophages into [...]

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Work TypeBook Chapter
Published inCurrent Multidisciplinary Approach to Diabetes Mellitus Occurrence Mechanism
First Page29
Last Page36
DOIhttps://doi.org/10.69860/nobel.9786053359104.3
ISBN978-605-335-910-4 (PDF)
LanguageENG
Page Count8
Copyright HolderNobel Tıp Kitabevleri
Licensehttps://nobelpub.com/publish-with-us/copyright-and-licensing

Histopathological changes in the diabetic pancreas are characterized by several key alterations that impact its structure and function. In type 1 diabetes mellitus (T1DM), autoimmune destruction of insulin-producing beta cells within the pancreatic islets results in their selective loss, termed insulitis. This process involves infiltration of immune cells such as T lymphocytes and macrophages into the islets, leading to progressive beta cell destruction and ultimately insulin deficiency. In contrast, type 2 diabetes mellitus (T2DM) is associated with insulin resistance and eventual beta cell dysfunction and depletion. Histologically, T2DM pancreases often show features of islet hypertrophy, where individual islets increase in size in response to chronic hyperglycemia and insulin resistance. Moreover, deposition of amyloid protein within the islets, known as islet amyloidosis, is commonly observed in T2DM and can contribute to beta cell dysfunction. These histopathological changes reflect the complex interplay of genetic, environmental, and metabolic factors in the pathogenesis of diabetes and highlight the importance of understanding pancreatic pathology for developing targeted therapies and interventions.

Aysenur Kaya (Author)
Research Assistant, Karamanoglu Mehmetbey University
https://orcid.org/0000-0002-3878-0087

Murat Cetin Ragbetli (Author)
Professor, Karamanoglu Mehmetbey University
https://orcid.org/0000-0002-8189-264X

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