Release Date: 2024-04-04

Neonatal Screenings for Congenital Hypothyroidism

Semra Cetinkaya (Author), Burce Orman (Author)

Release Date: 2024-04-04

Congenital hypothyroidism (CH), a condition where the thyroid gland hormone synthesis is affected, potentially leading to preventable mental retardation. It outlines the screening process for CH in newborns, the historical background of screening programs, different testing methods, and the implications of test results. Additionally, it covers treatment strategies and considerations for managing CH. CH occurs [...]

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Work TypeBook Chapter
Published inNewborn and Childhood Screening Programmes
First Page29
Last Page41
DOIhttps://doi.org/10.69860/nobel.9786053358961.2
ISBN978-605-335-896-1 (PDF)
LanguageENG
Page Count13
Copyright HolderNobel Tıp Kitabevleri
Licensehttps://nobelpub.com/publish-with-us/copyright-and-licensing

Congenital hypothyroidism (CH), a condition where the thyroid gland hormone synthesis is affected, potentially leading to preventable mental retardation. It outlines the screening process for CH in newborns, the historical background of screening programs, different testing methods, and the implications of test results. Additionally, it covers treatment strategies and considerations for managing CH. CH occurs at a frequency of 1:2000-1:4000 in newborns and can have permanent or temporary causes. Diagnosis typically occurs after three months, but early detection is crucial to prevent irreversible neurological effects. Screening programs aim to identify affected infants promptly, although challenges like false positives and negatives exist. Various testing methods, including primary TSH, primary T4, and combined T4 and TSH screening, are employed, each with its advantages and limitations. False-positive and false-negative results can occur due to factors like sampling time and test cut-off values. The text also discusses the CH screening program in a specific country, detailing the screening process and recall criteria. It emphasizes the importance of considering hypothyroidism in newborns with clinical symptoms, regardless of screening results, to prevent adverse neurodevelopmental outcomes. In conclusion, early detection and treatment of CH are crucial for preventing long-term complications. Screening programs play a vital role in identifying affected infants, but clinical evaluation remains essential for cases with suspicious symptoms. Effective management requires a comprehensive approach, including accurate testing, appropriate treatment, and regular monitoring.

Semra Cetinkaya (Author)
Professor, Saglık Bilimleri Universty
https://orcid.org/0000-0003-3974-2872
3Pediatric endocrinology and metabolism, Physiopathology; Prof Çetinkaya graduated from Ankara University Faculty of Medicine in 1996. She completed her specialization training in Hacettepe University, Department of Child Health and Diseases in 2001. She achieved my Pediatric Endocrinology and Metabolism minor specialization in Hacettepe University Faculty of Medicine Pediatric Endocrinology Unit in 2005. In 2022, she concluded my doctorate in Ankara University physiopathology and received the title of PHD. She has been working as a professor at the University of Health Sciences since 2017. She has about 155 international articles, 130 foreign/310 national oral/poster presentations and other studies.

Burce Orman (Author)
Saglık Bilimleri Universty
https://orcid.org/0000-0002-2737-7815
3Pediatric endocrinologist; Doctor Burçe Orman has been working in the field of pediatric endocrinology since 2020. She completed her university education at Başkent University Faculty of Medicine between 2008-2014. She became a pediatrician at Dr Sami Ulus Children’s Hospital between 2015-2019, and her pediatric endocrinology subspecialty training at Dr Sami Ulus Children’s Hospital between 2020-2023. She has published articles in the field of pediatric endocrinology and oral and poster presentations presented at national and international congresses.

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