Release Date: 2024-04-04

Screening of Fetal Aneuploidies Using Fetal Cell-Free DNA

Nevin Sagsoz (Author), Zerrin Orbak (Author)

Release Date: 2024-04-04

Fetal aneuploidies have been attempted to be screened since the 1970s. For this purpose, maternal age, various serum biochemical tests on maternal serum, and fetal ultrasonography have been used and are being used. However, it is observed that all these tests are insufficient to detect aneuploidies. The best screening method today is the cf-DNA test, [...]

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Work TypeBook Chapter
Published inNewborn and Childhood Screening Programmes
First Page177
Last Page183
DOIhttps://doi.org/10.69860/nobel.9786053358961.15
ISBN978-605-335-896-1 (PDF)
LanguageENG
Page Count7
Copyright HolderNobel Tıp Kitabevleri
Licensehttps://nobelpub.com/publish-with-us/copyright-and-licensing
Fetal aneuploidies have been attempted to be screened since the 1970s. For this purpose, maternal age, various serum biochemical tests on maternal serum, and fetal ultrasonography have been used and are being used. However, it is observed that all these tests are insufficient to detect aneuploidies. The best screening method today is the cf-DNA test, which is made from DNA particles of the fetus and placenta from the mother’s blood, and its detection rates are very high. The most important problem with this test today is cost.

Nevin Sagsoz (Author)
Professor, Kırıkkale University
https://orcid.org/0000-0002-9927-5877
3Professor Dr. Nevin Sağsöz is a scientist in the field of obstetrics and gynecology and has been working in this field for about 25 years. He completed his education as follows: Faculty/Doctorate: Atatürk University, Faculty of Medicine, Erzurum, Turkey (1984-1990); Postgraduate: Atatürk University, Faculty of Medicine, Erzurum, Turkey (1984-1990); Sub-specialty of obstetrics and gynecology: Perinatology-2011. She is a professor at Kırıkkale University, Kırıkkale, Turkey and has over 25 years of teaching and research experiences in academic settings in Turkey. She has also supervised many postgraguate theses. In addition, she has over a hundred published national and international articles, oral and poster presentations and numerous research projects.

Zerrin Orbak (Author)
Professor, Ataturk University
https://orcid.org/0000-0002-1847-9844
3After completing Atatürk University Faculty of Medicine in 1989, she started his specialty training at Atatürk University Faculty of Medicine, Department of Child Health and Diseases in the same year. She was appointed as an assistant professor to the same faculty in 1994. She completed his subspecialty training in the Department of Endocrinology and Metabolism at Ege University, Department of Pediatrics, between 1996 and 1998. She became an associate professor in 1998. In 1999, She took part in the establishment of the Pediatric Endocrinology and Metabolism Department within the Department of Pediatrics of Atatürk University Faculty of Medicine. Between August and December 2003, she served as an observing professor at the Ohio State University Children’s Hospital Department of Pediatric Endocrinology. She became a professor in March 2004. Between 2006 and 2008, she served as vice dean, purchasing commission chairman and pharmaceutical research ethics committee chairman. She has been the Head of the Department of Pediatric Endocrinology and Metabolism since 1999 and the Head of the Department of Pediatrics since 2017, and the Deputy Chief Physician since 2023. She is a member of ESPE (European Society of Pediatric Endocrinology), Endocrine Society and ISPAD (International Society for Pediatric and Adolescent Diabetes), Pediatric Endocrine and Diabetes Association, and Turkish National Pediatric Association. She worked as a manager and researcher in national multi-center projects, BAP and TÜBİTAK supported projects. She has over 150 international scientific studies, and presented at numerous national and international conferences. She has also supervised many postgraguate theses. She is currently the editor of the ""internal medicine"" section of ""The Eurasian Journal of Medicine"". The journal is included in the SCI-Expanded database.

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