Cytokines are low molecular weight glycoproteins that play a role in cell maturation, differentiation, inflammation, immunity and tissue repair. Cytokines are responsible for the propagation of the neuroinflammatory response as well as an indicator of the presence of the neuroinflammatory response. Although the neuroprotective and neurotrophic effects of cytokines have been demonstrated, it is well known that they are necessary for nerve development and maintenance of normal central nervous system functions. Cytokines reach the brain: Cytokines may be passively transported to brain cells from the circumventricular area, which lacks the blood-brain barrier. Second, cytokines may bind to the cerebral vascular endothelium, triggering the production of secondary transporters such as prostaglandin and nitric oxide. And it has been reported that the transport of cytokines through the blood-brain barrier via the carrier causes the activation of peripheral sensory nerve endings in the regions where the cytokines are released. It has been shown that peripheral cytokines, in addition to active transport, can also cross the blood-brain barrier through the choroid plexus regions.