Release Date: 2024-01-16

Dioxins

Muberra Ozcan (Author)

Release Date: 2024-01-16

Dioxins are toxic by-products of industrial combustion processes, characterized by being colorless, odorless, water-insoluble, and not commercially produced. These compounds, including both dioxins and furans, exhibit various properties and toxicity levels. Due to their high lipophilicity, they resist metabolic and environmental degradation, leading to their accumulation in animal-based foods and subsequent transfer to humans through [...]

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    Work TypeBook Chapter
    Published inFood Safety
    First Page211
    Last Page222
    DOIhttps://doi.org/10.69860/nobel.9786053358787.15
    Page Count12
    Copyright HolderNobel Tıp Kitabevleri
    Licensehttps://nobelpub.com/publish-with-us/copyright-and-licensing

    Dioxins are toxic by-products of industrial combustion processes, characterized by being colorless, odorless, water-insoluble, and not commercially produced. These compounds, including both dioxins and furans, exhibit various properties and toxicity levels. Due to their high lipophilicity, they resist metabolic and environmental degradation, leading to their accumulation in animal-based foods and subsequent transfer to humans through the food chain. They exert toxic effects via aryl hydrocarbon (AhR) receptors and induce the synthesis of enzymes crucial for xenobiotic biotransformation, resulting in increased enzyme levels in the liver. Dioxins, absorbed through the small intestine and transported via the bloodstream, accumulate in fatty tissues, particularly the liver. This slow elimination process leads to bioaccumulation with repeated exposure, causing diverse toxic effects on multiple bodily systems. Thus, developing and implementing effective environmental policies and preventive measures is critical to mitigate dioxin toxicity.

    Muberra Ozcan (Author)
    Research Assistant, Istanbul Universty
    https://orcid.org/0000-0002-8014-6717
    3Res. Asst. Müberra Özcan graduated from the Faculty of Pharmacy at Marmara University in 2019. In the same year, she was admitted to the Ph.D. program in Pharmaceutical Toxicology at Istanbul University, where she began cell culture-based studies on mycotoxins. Between 2021 and 2023, she served as a lecturer and head of the Pharmacy Services Department at Doğuş University. Since 2023, she has been continuing her role as a research assistant in the Department of Pharmaceutical Toxicology at the Faculty of Pharmacy, Süleyman Demirel University.

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