In this section, management of brain metastasis in patients with prostat cancer is highlighted. There is no established guidelines for the treatment of brain metastases which are relatively rare compared to other sites of prostate cancer metastases. Hence, this condition requires a multidisciplinary and multimodality approach including systemic therapy, radiotherapy and surgery. Metastasis-directed therapy is known to improve overall survival, however, it is obvious that more studies are needed to provide insight in this field. Also, the importance of the inclusion of the brain in routine cancer metastasis screening and the inclusion of people with metastases in clinical trials has been emphasized.