Parkinson disease is a neurodegenerative disease that affects dopaminergic neurons in the substantia nigra. Parkinson’s disease is a disease that occurs with unwanted and uncontrolled movements, causing balance and coordination difficulties, resulting in tremor paralysis. Due to symptoms such as tremors, Parkinson disease significantly affects a person’s quality of life and can worsen if left untreated. In this section, the relationship between important biochemical parameters such as dopamine, insulin resistance, vitamin D, glycemic index, cholesterol, proteins and minerals, which have very important roles in the prognosis and treatment process of Parkinson, and Parkinson’s is evaluated. We believe that clinicians can manage the disease process more efficiently and effectively by taking into account the points expressed in this section in every process of Parkinson disease.