Release Date: 2024-01-16

Safety of Food Additives: Sweeteners

Ahmet Dundar (Author)

Release Date: 2024-01-16

Aspartame, acesulfame K, cyclamate, sucralose, steviol, saccharin, neotame and glycosides are known as artificial sweeteners. Such sweeteners are considered as risk factors in the pathophysiology of many diseases such as obesity, cancer, neurological diseases and cardiovascular diseases. However, the role of artificial sweeteners in the mechanism of action of diseases has not been fully explained. [...]

Media Type
    Buy from

    Price may vary by retailers

    Work TypeBook Chapter
    Published inFood Safety
    First Page13
    Last Page20
    DOIhttps://doi.org/10.69860/nobel.9786053358787.2
    Page Count8
    Copyright HolderNobel Tıp Kitabevleri
    Licensehttps://nobelpub.com/publish-with-us/copyright-and-licensing

    Aspartame, acesulfame K, cyclamate, sucralose, steviol, saccharin, neotame and glycosides are known as artificial sweeteners. Such sweeteners are considered as risk factors in the pathophysiology of many diseases such as obesity, cancer, neurological diseases and cardiovascular diseases. However, the role of artificial sweeteners in the mechanism of action of diseases has not been fully explained. In the pathophysiological mechanism, it has been shown that artificial sweeteners cause oxidative damage, create an imbalance between anti-oxidant and oxidant, and cause health problems by stimulating inflammation. As a result, it was concluded in this study that more clinical and experimental studies should be conducted to evaluate the mechanisms of action of artificial sweeteners and to protect public health. It has also been shown that in a healthy diet, artificial sweeteners should be removed from the diet as much as possible and the use of packaged foods should be avoided.

    Ahmet Dundar (Author)
    Assoc. Prof, Mardin Artuklu University
    https://orcid.org/0000-0003-0527-189X
    3Dr.Ahmet DÜNDAR works as an Associate Professor at Mardin Artuklu University Vocational School of Health Services, Department of Medical Services and Techniques. He received his undergraduate degree from Yüzüncü Yıl University, Faculty of Science. He continued his master’s and doctorate degrees at the same university’s Institute of Health Sciences, Faculty of Medicine, Department of Medical Biochemistry. In 2014, he started working as an assistant professor at Dicle Health Services Vocational School, Department of Medical Services and Techniques. In 2018, he was appointed as a faculty member at Mardin Artuklu University, Vocational School of Health Services, Department of Medical Services and Techniques. His main research areas include antioxidants, oxidative stress, vitamins, inflammation, biochemical evaluation of neurological diseases and molecular genetics. He graduated 2 MSc students. He has completede 4 projects.

    • EUR-Lex-32011R1129-EN-EUR-Lex. Available online: https://eur-lex.europa.eu/legal-content/ES/ ALL/?uri=CELEX:32011R1129

    • World Health Organization. Guideline: sugars intake for adult and children. Geneva: World Health Organization; 2015

    • Dlamini S.N. Master’s Thesis. College of Agriculture; Engineering and Science School of Life Sciences Discipline of Biochemistry, University of KwaZulu-Natal, KwaZulu-Natal, South Africa: 2014. Effects of Commercially Available Sugar Substitutes in an Experimentally Induced Rat Model of Type 2 Diabetes

    • US Food and Drug Administration. Aspartame: Commissioneraposs final decision. Fed Reg 1981;46(142):38285–308

    • Matsuzawa Y., O’Hara Y. Physiology and Biochemistry . New York, Marcel Dekker: 2020. Tissue distribution of orally administered isotopically labeled aspartame in the rat; pp. 161–199.

    • Pardridge W. M. Nutrition and the Brain. New York: Raven Press; 1986. Potential effects of the dipeptide sweetener aspartame on the brain; pp. 199–241.

    • Soffritti M, Belpoggi F, Degli Esposti D, Lambertini L. Aspartame induces lymphomas and leukaemias in rats. Eur J Oncol 2005; 10: 107–16.

    • Soffritti M, Belpoggi F, Esposti DD, Falcioni L, Bua L.Basic Clin Pharmacol Toxicol. 2008 Feb;102(2):118-24

    • Hagiwara A, Fukushima S, Kitaori M, Shibata M, Ito N. Effects of three sweeteners on rat urinary bladder carcinogenesis initiated by N-butyl-N-(4-hydroxybutyl)-nitrosamine. Gan. 1984 Sep;75(9):763-8.

    • 10.1097/00005072-199611000-00002.

    • Study E33-34 in Master file 134 on aspartame. On file at the FDA Hearing Clerk’s Office 2001.

    • Okoduwa S.I.R., Ebiloma G.U., Baba J., Ajide S. The metabolism and toxicology of saccharin. Infohealth Aware. Artic. 2013;1:14–19

    • Kessler II, Clark JP. Saccharin, cyclamate, and human bladder cancer. No evidence of an association. JAMA. 1978 Jul 28;240(4):349-55.

    • Gougeon R., Spidel M., Lee K., Field C.J. Canadian Diabetes Association National Nutrition Commitee Technicl Review: Non-nutritive Intense Sweeteners in Diabetis Management. Can. J. Diabetes. 2004;28:385–399.

    • Amin KA, Al-muzafar HM, Abd Elsttar AH. Effect of sweetener and flavoring agent on oxidative indices, liver and kidney function levels in rats.Indian J Exp Biol. 2016 Jan;54(1):56-63

    • Amin KA, AlMuzafar HM. Alterations in lipid profile, oxidative stress and hepatic function in rat fed with saccharin and methyl-salicylates.Int J Clin Exp Med. 2015 Apr 15;8(4):6133-44. eCollection 2015

    onix_3.0::thothThoth ONIX 3.0
    onix_3.0::project_museProject MUSE ONIX 3.0
    onix_3.0::oapenOAPEN ONIX 3.0
    onix_3.0::jstorJSTOR ONIX 3.0
    onix_3.0::google_booksGoogle Books ONIX 3.0
    onix_3.0::overdriveOverDrive ONIX 3.0
    onix_2.1::ebsco_hostEBSCO Host ONIX 2.1
    csv::thothThoth CSV
    json::thothThoth JSON
    kbart::oclcOCLC KBART
    bibtex::thothThoth BibTeX
    doideposit::crossrefCrossRef DOI deposit
    onix_2.1::proquest_ebraryProQuest Ebrary ONIX 2.1
    marc21record::thothThoth MARC 21 Record
    marc21markup::thothThoth MARC 21 Markup
    marc21xml::thothThoth MARC 21 XML

    Share This Chapter!