Food, directly affects human health. The phrase ‘you are what you eat’ describes the importance of food for humans. Therefore, food safety is very important. Unfortunately, today, consciously or unconsciously, the contents of foods are tampered with, and food safety is put at great risk. Foods that are a source of healing are thus transformed into harmful substances. Glucose and fructase are carbohydrates that can be added externally to foods. The biggest cause of an important disease such as diabetes is the increase in carbohydrates in the blood. These two sugars lead to an increase in blood sugar. Synthetic and natural ones are easily added to foods. Therefore, in this chapter, the importance and effects of glucose and fructose sugars on food safety are compiled with current studies.