Antibiotics play a vital role in managing bacterial infections in both humans and animals, making their use in food animals particularly significant. Due to their importance, the administration of antibiotics in livestock must be handled with precision, ensuring they are used strictly according to recommended dosages and under close supervision. Adhering to prescribed waiting periods following antibiotic treatment in animals is crucial to ensure that any residues are adequately cleared before the animals enter the food supply. To ensure the responsible use of antibiotics in food animals, it is ideal that only veterinary professionals administer these medications. This approach helps guarantee that antibiotics are used appropriately and only when necessary, thereby reducing the risk of antibiotic resistance and other related issues. Additionally, integrating genetic advancements and biological agents, such as vaccines, offers promising alternatives to the use of low doses of antibiotics in managing animal diseases. These methods can effectively prevent and control infections, reducing the need for antibiotics and subsequently lowering the levels of antibiotic residues that may be transmitted to humans through the environment and food products. By minimizing the use of antibiotics in food animals, we can significantly decrease the presence of antibiotic residues in the food chain. This reduction is essential for mitigating the potential adverse health effects on humans. When antibiotic residues enter the human body through food consumption, they can contribute to the development of antibiotic-resistant bacteria, posing a serious public health threat. Therefore, adopting strategies that limit antibiotic use in food animals, such as improved veterinary oversight, genetic improvements, and the use of vaccines, is critical for safeguarding human health. Moreover, these practices contribute to more sustainable and responsible animal husbandry. By focusing on preventive measures and alternative disease management strategies, we can enhance animal health and welfare while simultaneously protecting human health. This holistic approach not only addresses the immediate concerns of antibiotic residues but also promotes long-term solutions for disease control in animal populations. As a result, we can create a safer food supply and a healthier environment, benefiting both current and future generations.