Release Date: 2024-01-16

Ochratoxins

Hilal Ozgunes (Author), Izem Bilinmis (Author), Senanur Ozsoy (Author)

Release Date: 2024-01-16

In this section, ochratoxins are described in general, and their effects on human health and the toxic effects are particularly discussed. Ochratoxins are considered to be among the mycotoxins with significant health implications due to their widespread presence in food and feed. Among the ochratoxin types, Ochratoxin A was mainly mentioned, because Ochratoxin A is [...]

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    Work TypeBook Chapter
    Published inFood Safety
    First Page87
    Last Page105
    DOIhttps://doi.org/10.69860/nobel.9786053358787.6
    LanguageENG
    Page Count19
    Copyright HolderNobel Tıp Kitabevleri
    Licensehttps://nobelpub.com/publish-with-us/copyright-and-licensing

    In this section, ochratoxins are described in general, and their effects on human health and the toxic effects are particularly discussed. Ochratoxins are considered to be among the mycotoxins with significant health implications due to their widespread presence in food and feed. Among the ochratoxin types, Ochratoxin A was mainly mentioned, because Ochratoxin A is the most prevalent and relevant fungal toxin of this group. Ochratoxins are a group of naturally occurring mycotoxins produced by fungi belonging to the genera Aspergillus and Penicillium. These toxins are known to contaminate various agricultural commodities such as cereals, coffee beans, grapes, and nuts, particularly under conditions of high humidity and poor storage. Chronic exposure to ochratoxins, primarily through contaminated food, has been associated with kidney disease (nephropathy) in humans. In addition, ochratoxins have carcinogenic, hepatotoxic, mutagenic and teratogenic toxic effects. Many countries have set maximum limits for ochratoxin levels in food and feed to protect public health. Strategies to prevent ochratoxin contamination include good agricultural practices, proper storage conditions, and regular monitoring of food and feed supplies.

    Hilal Ozgunes (Author)
    Professor, Başkent University
    https://orcid.org/0000-0002-5561-3491
    3Prof. Dr Hilal Özgüneş graduated from Hacettepe University Faculty of Pharmacy in 1974. She received her PhD degree in Pharmaceutical Toxicology in 1982. The subject of her doctorate is ""Lead, copper and zinc levels in canned tomato paste."" She received the title of associate Professor in 1986 and Professor in 1995 in the field of Pharmaceutical Toxicology. Topics of important scientific interests include lead toxicity, trace elements, oxidative stress and antioxidants. Her scientific studies have been published in numerous national and international journals and presented at ational and international congresses.

    Izem Bilinmis (Author)
    Research Assistant, Başkent University
    https://orcid.org/0000-0001-9471-7325
    3Res. Asst. İzem Bilinmiş graduated from Marmara University Faculty of Pharmacy in 2021. After graduation, she worked as a regulatory and market access specialist in a company for 1 year. In 2021, she started her master’s degree in the Department of Pharmaceutical Toxicology at Hacettepe University Faculty of Pharmacy and is still continuing. She is currently working at Başkent University Faculty of Pharmacy in the Department of Pharmaceutical Toxicology. Her scientific interests are endocrine disrupting chemicals, occupational toxicology.

    Senanur Ozsoy (Author)
    Research Assistant, Başkent University
    https://orcid.org/0009-0002-8165-6847
    3Res. Asst. Senanur ÖZSOY graduated from the Faculty of Pharmacy at Erzincan Binali Yıldırım University in 2023. In the same year, she was admitted to the Ph.D. program in Pharmaceutical Toxicology at Ankara University. Since 2023, she has been working as a Research Assistant in the Pharmaceutical Toxicology Department at Başkent University Faculty of Pharmacy.

    • Alshannaq A, Yu JH. Occurrence, Toxicity, and Analysis of Major Mycotoxins in Food. Int J Environ Res Public Health. 2017;14(6).

    • Aycan C, Elif O. Mycotoxins: The Hidden Danger in Foods. In: Suna S, editor. Mycotoxins and Food Safety. Rijeka: IntechOpen; 2019. p. Ch. 4.

    • El-Sayed RA, Jebur AB, Kang W, El-Demerdash FM. An overview on the major mycotoxins in food products: characteristics, toxicity, and analysis. Journal of Future Foods. 2022;2(2):91-102.

    • Awuchi CG, Ondari EN, Ogbonna CU, Upadhyay AK, Baran K, Okpala COR, et al. Mycotoxins Affecting Animals, Foods, Humans, and Plants: Types, Occurrence, Toxicities, Action Mechanisms, Prevention, and Detoxification Strategies-A Revisit. Foods. 2021;10

    • Wang L, Hua X, Shi J, Jing N, Ji T, Lv B, et al. Ochratoxin A: Occurrence and recent advances in detoxification. Toxicon. 2022

    • Awuchi CG, Ondari EN, Ogbonna CU, Upadhyay AK, Baran K, Okpala COR, et al. Mycotoxins Affecting Animals, Foods, Humans, and Plants: Types, Occurrence, Toxicities, Action Mechanisms, Prevention, and Detoxification Strategies—A Revisit

    • Mwabulili F, Xie Y, Li Q, Sun S, Yang Y, Ma W. Research progress of ochratoxin a bio-detoxification. Toxicon. 2023;222:107005.

    • Cho SM, Jeong SE, Lee KR, Sudhani HP, Kim M, Hong SY, et al. Biodegradation of Ochratoxin A by Aspergillus tubingensis Isolated from Meju. J Microbiol Biotechnol. 2016;26(10):1687-95.

    • Chain EPoCitF, Schrenk D, Bodin L, Chipman JK, del Mazo J, Grasl‐Kraupp B, et al. Risk assessment of ochratoxin A in food. EFSA journal. 2020;18(5):e06113.

    • Bui-Klimke TR, Wu F. Ochratoxin A and human health risk: a review of the evidence. Crit Rev Food Sci Nutr. 2015;55(13):1860-9.

    • Liu W-C, Pushparaj K, Meyyazhagan A, Arumugam VA, Pappuswamy M, Bhotla HK, et al. Ochratoxin A as an alarming health threat for livestock and human: A review on molecular interactions, mechanism of toxicity, detection, detoxification, and dietary prophylaxis. Toxicon. 2022;213:59-75.

    • Ganesan AR, Mohan K, Karthick Rajan D, Pillay AA, Palanisami T, Sathishkumar P, et al. Distribution, toxicity, interactive effects, and detection of ochratoxin and deoxynivalenol in food: A review. Food Chemistry. 2022;378:131978.

    • Yazdanfar N, Mahmudiono T, Fakhri Y, Mahvi AH, Sadighara P, Mohammadi AA, et al. Concentration of ochratoxin A in coffee products and probabilistic health risk assessment. Arabian Journal of Chemistry. 2022;15(12):104376

    • Kőszegi T, Poór M. Ochratoxin A: Molecular Interactions, Mechanisms of Toxicity and Prevention at the Molecular Level. Toxins (Basel). 2016;8(4):111.

    • Kumar P, Mahato DK, Sharma B, Borah R, Haque S, Mahmud MMC, et al. Ochratoxins in food and feed: Occurrence and its impact on human health and management strategies. Toxicon. 2020;187:151- 62

    • Ding L, Han M, Wang X, Guo Y. Ochratoxin A: Overview of Prevention, Removal, and Detoxification Methods. Toxins (Basel). 2023;15(9).

    • Amézqueta S, González-Peñas E, Murillo-Arbizu M, López de Cerain A. Ochratoxin A decontamination: A review. Food Control. 2009;20(4):3

    • Ringot D, Chango A, Schneider YJ, Larondelle Y. Toxicokinetics and toxicodynamics of ochratoxin A, an update. Chem Biol Interact. 2006;159(1):18-46.

    • Wu Q, Dohnal V, Huang L, Kuča K, Wang X, Chen G, et al. Metabolic pathways of ochratoxin A. Curr Drug Metab. 2011;12(1):1-10

    • Groopman JD, Kensler TW, Wu F. Food Safety: Mycotoxins – Occurrence and Toxic Effects. In: Caballero B, editor. Encyclopedia of Human Nutrition (Third Edition). Waltham: Academic Press; 2013. p. 337-41.

    • El Khoury A, Atoui A. Ochratoxin A: General Overview and Actual Molecular Status. Toxins. 2010;2:461 - 93.

    • Tao Y, Xie S, Xu F, Liu A, Wang Y, Chen D, et al. Ochratoxin A: Toxicity, oxidative stress and metabolism. Food and Chemical To

    • Stoev SD, Paskalev M, MacDonald S, Mantle PG. Experimental one year ochratoxin A toxicosis in pigs. Experimental and Toxicologic Pathology. 2002;53(6):481-7

    • Reddy L, Bhoola K. Ochratoxins-food contaminants: impact on human health. Toxins (Basel). 2010;2(4):771-9.

    • Malir F, Ostry V, Pfohl-Leszkowicz A, Malir J, Toman J. Ochratoxin A: 50 Years of Research. Toxins (Basel). 2016;8(7).

    • Chen W, Li C, Zhang B, Zhou Z, Shen Y, Liao X, et al. Advances in Biodetoxification of Ochratoxin A-A Review of the Past Five Decades. Front Microbiol. 2018;9:1386.

    • Afsah-Hejri L, Hajeb P, Ehsani RJ. Application of ozone for degradation of mycotoxins in food: A review. Compr Rev Food Sci Food Saf. 2020;19(4):1777-808.

    • Haque MA, Wang Y, Shen Z, Li X, Saleemi MK, He C. Mycotoxin contamination and control strategy in human, domestic animal and poultry: A review. Microb Pathog. 2020;142:104095.

    • Hedayati N, Naeini MB, Nezami A, Hosseinzadeh H, Wallace Hayes A, Hosseini S, et al. Protective effect of lycopene against chemical and natural toxins: A review. Biofactors. 2019;45(1):5-

    • Wang G, Li E, Gallo A, Perrone G, Varga E, Ma J, et al. Impact of environmental factors on ochratoxin A: From natural occurrence to control strategy. Environ Pollut. 2023;317:120767.

    • Claeys L, Romano C, De Ruyck K, Wilson H, Fervers B, Korenjak M, et al. Mycotoxin exposure and human cancer risk: A systematic review of epidemiological studies. Comprehensive Reviews in Food Science and Food Safety. 2020;19(4):1449-64

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