Cases of poisoning caused by seafood are common around the world, especially in developing sea and ocean coastal countries. Domoic acid, which became popular with the mass poisoning case in the 1980s, was actually used in alternative treatment practices. Poisoning caused by domoic acid is called amnesic shellfish poisoning. Although poisoning caused by humans attracts more attention, mass poisoning cases caused by other creatures such as sea lions are also important for the ecosystem. Domoic acid poisoning cases are mostly observed after algal blooms. The effects of acute poisoning are fatal and can also lead to chronic poisoning, leading to serious neurological disorders in the longer term. Several different species of Pseudo-nitzschia produced the domoic acid. There is no complete treatment for domoic acid poisoning yet, and studies on treatment strategies are continuing.