Release Date: 2024-01-16

Toxicity of Domoic Acid

Mehtap Kara (Author)

Release Date: 2024-01-16

Cases of poisoning caused by seafood are common around the world, especially in developing sea and ocean coastal countries. Domoic acid, which became popular with the mass poisoning case in the 1980s, was actually used in alternative treatment practices. Poisoning caused by domoic acid is called amnesic shellfish poisoning. Although poisoning caused by humans attracts [...]

Media Type
    Buy from

    Price may vary by retailers

    Work TypeBook Chapter
    Published inFood Safety
    First Page155
    Last Page166
    DOIhttps://doi.org/10.69860/nobel.9786053358787.11
    Page Count12
    Copyright HolderNobel Tıp Kitabevleri
    Licensehttps://nobelpub.com/publish-with-us/copyright-and-licensing
    Cases of poisoning caused by seafood are common around the world, especially in developing sea and ocean coastal countries. Domoic acid, which became popular with the mass poisoning case in the 1980s, was actually used in alternative treatment practices. Poisoning caused by domoic acid is called amnesic shellfish poisoning. Although poisoning caused by humans attracts more attention, mass poisoning cases caused by other creatures such as sea lions are also important for the ecosystem. Domoic acid poisoning cases are mostly observed after algal blooms. The effects of acute poisoning are fatal and can also lead to chronic poisoning, leading to serious neurological disorders in the longer term. Several different species of Pseudo-nitzschia produced the domoic acid. There is no complete treatment for domoic acid poisoning yet, and studies on treatment strategies are continuing.

    Mehtap Kara (Author)
    Associate Professor, Istanbul Universty
    https://orcid.org/0000-0001-7764-5593
    3Assoc. Prof. was born on September 05, 1984. Dr. Mehtap Kara completed her undergraduate education at Istanbul University Cerrahpaşa Faculty of Medicine, Department of Medical Biological Sciences in 2006. She completed his master’s degree at Istanbul University, Institute of Health Sciences, Department of Medical Biology in 2009. In 2016, she completed the Pharmaceutical Toxicology program at Istanbul University Faculty of Pharmacy and received her doctor of science degree. Since 2016, she continued her studies at Istanbul University Faculty of Pharmacy, Department of Pharmaceutical Toxicology, and on 19.01.2022, she received the title of associate professor in her field. The author has a total of 21 articles in SCI/SCI-E comprehensive journals and 15 articles in field indexed journals. The author has 4 international book chapters.

    • Pulido, Olga M. Domoic acid toxicologic pathology: a review. Marine Drugs, 2008, 6.2: 180-219.

    • https://www.kcbx.org/environment-and-energy/2022-09-26/hundreds-of-sea-lions-treated-for-domoic- acid-poisoning-in-santa-barbara-and-ventura-counties

    • https://www.kcbx.org/pets-animals/2017-07-21/algae-bloom-suspected-of-sickening-sea-lions

    • Wright JL, Bird CJ, de Freitas AS, Hampson D, McDonald J, Quilliam MA. Chemistry, biology, and toxicology of domoic acid and its isomers. Can Dis Wkly Rep. 1990 Sep;16 Suppl 1E:21-6.

    • Quıllıam, M. A. Chemical methods for domoic acid, the amnesic shellfish poisoning (ASP) toxin. Manual on harmful marine microalgae, monographs on oceanographic methodology, 2003, 11: 247- 266.

    • La Barre, S., Bates, S. S., & Quilliam, M. A.. Domoic acid. Outstanding Marine Molecules. (2014;189- 216.

    • Lefebvre KA, Robertson A. Domoic acid and human exposure risks: a review. Toxicon. 2010 Aug 15;56(2):218-30.

    • Zheng G, Wu H, Che H, Li X, Zhang Z, Peng J, Guo M, Tan Z. Residue Analysis and Assessment of the Risk of Dietary Exposure to Domoic Acid in Shellfish from the Coastal Areas of China. Toxins (Basel). 2022 Dec 8;14(12):862

    • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9783215/

    • Alexander, Jan & Benford, et al. Marine biotoxins in shellfish-Domoic acid, EFSA Scientific Opinion. EFSA Journal. EFSA, A. E. Marine biotoxins in shellfish–Domoic acid: Scientific Opinion of the Panel on Contaminants in the Food Chain. The EFSA Journal, 2009: 1181, 1-61

    • Barbaro E, Zangrando R, Barbante C, Gambaro A. Fast and Sensitive Method for Determination of Domoic Acid in Mussel Tissue. ScientificWorldJournal. 2016;2016:8404092.

    • Smith, D. S., & Kitts, D. D. A competitive enzyme-linked immunoassay for domoic acid determination in human body fluids. Food and chemical toxicology. 1994; 32(12), 1147-1154.

    • Peteva, Zlatina & Georgieva, Stanislava & Stancheva, Mona. Recent Updates Of Hplc-Uv And Lc-Ms Methods For Domoic Acid Detection: A Comparison Review. 2018; 12. 227-237.

    • Congestri, R., Micheli, L., & Palleschi, G. Monitoring domoic acid in marine phytoplankton by disposable immunosensors. American Journal of Plant Sciences. 2017; 8(6), 1077-1091.

    • R. Petroffa, M. Muriasb, K.S. Grant, B. Crouthamel, N. McKain, S. Shumd, J. Jing, N. Isoherranend, T.M. Burbacher. Power spectrum analysis of EEG in a translational nonhuman primate model after chronic exposure to low levels of the common marine neurotoxin, domoic acid. Neurotoxicology. 2020;80: 124–129

    • Carvalho PS, Catian R, Moukha S, Matias WG, Creppy EE. Comparative study of Domoic Acid and Okadaic Acid induced-chromosomal abnormalities in the Caco-2 cell line. Int J Environ Res Public Health. 2006 Mar;3(1):4-10

    • Jing J, Petroff R, Shum S, Crouthamel B, Topletz AR, Grant KS, Burbacher TM, Isoherranen N. Toxicokinetics and Physiologically Based Pharmacokinetic Modeling of the Shellfish Toxin Domoic Acid in Nonhuman Primates. Drug Metab Dispos. 2018 Feb;46(2):155-165.

    • Nguyen HN, Smith ME, Swoboda HD. Shellfish Toxicity. 2024 Jan 30. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 29262048.

    • Maucher Fuquay J, Muha N, Wang Z, Ramsdell JS. Toxicokinetics of domoic acid in the fetal rat. Toxicology. 2012 Mar 29;294(1):36-41.

    • Kumar KP, Kumar SP, Nair GA. Risk assessment of the amnesic shellfish poison, domoic acid, on animals and humans. J Environ Biol. 2009 May;30(3):319-25

    • Costa LG, Giordano G, Faustman EM. Domoic acid as a developmental neurotoxin. Neurotoxicology. 2010 Sep;31(5):409-23.

    • Jeffery B, Barlow T, Moizer K, Paul S, Boyle C. Amnesic shellfish poison. Food Chem Toxicol. 2004 Apr;42(4):545-57

    • Ramsdell JS, Gulland FM. Domoic Acid Epileptic Disease. Marine Drugs. 2014; 12(3):1185-1207.

    • Grattan, L. M., Boushey, C. J., Liang, Y., Lefebvre, K. A., Castellon, L. J., Roberts, K. A., ... & Morris Jr, J. G. (2018). Repeated dietary exposure to low levels of domoic acid and problems with everyday memory: Research to public health outreach. Toxins, 10(3), 103.

    • Radad K, Moldzio R, Al-Shraim M, Al-Emam A, Rausch WD. Long-term neurotoxic effects of domoic acid on primary dopaminergic neurons. Toxicol In Vitro. 2018 Oct;52:279-285.

    • More SV, Kumar H, Cho DY, Yun YS, Choi DK. Toxin-Induced Experimental Models of Learning and Memory Impairment. Int J Mol Sci. 2016 Sep 1;17(9):1447

    • Doucette TA, Tasker RA. Perinatal Domoic Acid as a Neuroteratogen. Curr Top Behav Neurosci. 2016;29:87-110.

    • Dakshinamurti K, Sharma SK, Sundaram M, Watanabe T (1993) Hippocampal changes in developing postnatal mice following intrauterine exposure to domoic acid. J Neurosci 13 (10):4486–4495

    • Maucher JM, Ramsdell JS (2007) Maternal-fetal transfer of domoic acid in rats at two gestational time points. Environ Health Perspect 115(12):1743–1746

    • Maucher-Fuquay J, Muha N, Wang Z, Ramsdell JS (2012) Elimination kinetics of domoic acid from the brain and cerebrospinal fluid of the pregnant rat. Chem Res Toxicol 25(12):2805–2809

    • Tiedeken JA, Ramsdell JS (2007) Embryonic exposure to domoic acid increases the susceptibility of zebrafish larvae to the chemical convulsant pentylenetetrazole. Environ Health Perspect 115 (11):1547–1552

    • Tiedeken JA, Ramsdell JS, Ramsdell AF (2005) Developmental toxicity of domoic acid in zebrafish (Danio rerio). Neurotoxicol Teratol 27(5):711–717

    • Panlilio JM, Aluru N, Hahn ME. Developmental Neurotoxicity of the Harmful Algal Bloom Toxin Domoic Acid: Cellular and Molecular Mechanisms Underlying Altered Behavior in the Zebrafish Model. Environ Health Perspect. 2020 Nov;128(11):117002

    • Grant KS, Crouthamel B, Kenney C, McKain N, Petroff R, Shum S, Jing J, Isoherranen N, Burbacher TM. Preclinical modeling of exposure to a global marine bio-contaminant: Effects of in utero Domoic acid exposure on neonatal behavior and infant memory. Neurotoxicol Teratol. 2019 May-Jun;73:1-8

    • Jakaria M, Park SY, Haque ME, Karthivashan G, Kim IS, Ganesan P, Choi DK. Neurotoxic Agent-Induced Injury in Neurodegenerative Disease Model: Focus on Involvement of Glutamate Receptors. Front Mol Neurosci. 2018 Aug 29;11:307

    • D’Agostino VC, Fernández Ajó A, Degrati M, Krock B, Hunt KE, Uhart MM, Buck CL. Potential endocrine correlation with exposure to domoic acid in Southern Right Whale (Eubalaena australis) at the Península Valdés breeding ground. Oecologia. 2022 Jan;198(1):21-34.

    • Pizzo F, Caloni F, Schreiber NB, Schutz LF, Totty ML, Albonico M, Spicer LJ. Direct effects of the algal toxin, domoic acid, on ovarian function: Bovine granulosa and theca cells as an in vitro model. Ecotoxicol Environ Saf. 2015 Mar;113:314-20

    • Vranyac-Tramoundanas A, Harrison JC, Clarkson AN, Kapoor M, Winburn IC, Kerr DS, Sammut IA. Domoic acid impairment of cardiac energetics. Toxicol Sci. 2008 Oct;105(2):395-407

    • Hong Z, Zhang Y, Zuo Z, Zhu R, Gao Y. Influences of domoic Acid exposure on cardiac development and the expression of cardiovascular relative genes in zebrafish (Daniorerio) embryos. J Biochem Mol Toxicol. 2015 Jun;29(6):254-60

    • Vieira AC, Cifuentes JM, Bermúdez R, Ferreiro SF, Castro AR, Botana LM. Heart Alterations after Domoic Acid Administration in Rats. Toxins (Basel). 2016 Mar 10;8(3):68

    • Funk JA, Janech MG, Dillon JC, Bissler JJ, Siroky BJ, Bell PD. Characterization of renal toxicity in mice administered the marine biotoxin domoic Acid. J Am Soc Nephrol. 2014 Jun;25(6):1187-97.

    • Wu DM, Lu J, Zhang YQ, Zheng YL, Hu B, Cheng W, Zhang ZF, Li MQ. Ursolic acid improves domoic acid-induced cognitive deficits in mice. Toxicol Appl Pharmacol. 2013 Sep 1;271(2):127-36

    • Saeed, A. F., Awan, S. A., Ling, S., Wang, R., & Wang, S. (2017). Domoic acid: Attributes, exposure risks, innovative detection techniques and therapeutics. Algal Research, 24, 97-110.

    • Glavin, G. B., & Pinsky, C. (1989). Kynurenic acid attenuates experimental ulcer formation and basal gastric acid secretion in rats. Research communications in chemical pathology and pharmacology, 64(1), 111-119.

    Share This Chapter!