Release Date: 2024-06-10

Piper Nigrum L.

Release Date: 2024-06-10

Piper nigrum L., commonly known as black pepper, is a species of tropical plant and belongs to the family Piperaceae. Black pepper is a very common spice around the world and is often used to add flavor to dishes. The active ingredients found in black pepper have antioxidant and anti-inflammatory properties. These properties indicate that [...]

Media Type
    Buy from

    Price may vary by retailers

    Work TypeBook Chapter
    Published inMedicinal Spices
    First Page69
    Last Page81
    DOIhttps://doi.org/10.69860/nobel.9786053359340.5
    Page Count13
    Copyright HolderNobel Tıp Kitabevleri
    Licensehttps://nobelpub.com/publish-with-us/copyright-and-licensing
    Piper nigrum L., commonly known as black pepper, is a species of tropical plant and belongs to the family Piperaceae. Black pepper is a very common spice around the world and is often used to add flavor to dishes. The active ingredients found in black pepper have antioxidant and anti-inflammatory properties. These properties indicate that black pepper may have effects such as supporting digestive health, speeding up metabolism and strengthening the immune system. Additionally, some studies suggest that black pepper may have pain-relieving properties.

    Sepideh Feizollahi (Author)
    Istanbul Universty
    https://orcid.org/0009-0002-2517-8481
    3Sepideh Feizollahi graduated with a Bachelor’s degree in Biochemistry from Islamic Azad University, Iran, in 2014. She obtained her Master’s degree in Biochemistry from Islamic Azad University, Iran, in 2016. Currently, she is a Ph.D. student in the Department of Biology, Botany sub-branch, at Istanbul University. In 2022, as part of a BAP project at Istanbul University, she conducted research for 5 months on the phytochemical analyses, determination of antioxidant activities, and in vitro bioavailability of cherry genetic resources distributed in Giresun and surrounding areas. In 2023 and 2024, under a Tübitak project at Istanbul University, she investigated the physiological, biochemical, and molecular effects of brassinosteroid application on the phytoremediation of microplastics and cadmium in Azolla. In 2023, as part of a BAP project at Istanbul University, she studied the effects of brassinosteroid and gibberellic acid on cadmium detoxification in Pinnata R.Br.

    • Ahmad, N., Fazal, H., Abbasi, B. H., Farooq, S., Ali, M., & Khan, M. A. Biological role of Piper nigrum L.(Black pepper): A review. Asian Pacific Journal of Tropical Biomedicine. 2012; S1945-S1953.

    • Acharya, S. G., Momin, A. H., & Gajjar, A. V. Review of piperine as a bio-enhancer. Am J Pharm Tech Res. 2012; 32-44.

    • Taqvi, S. I. H., Shah, A. J., & Gilani, A. H. Blood pressure lowering and vasomodulator effects of piperine. Journal of cardiovascular pharmacology. 2008; 452-458.

    • Manoharan, S., Balakrishnan, S., Menon, V. P., Alias, L. M., & Reena, A. R. Chemopreventive efficacy of curcumin and piperine during 7, 12-dimethylbenz (a) anthracene-induced hamster buccal pouch carcinogenesis. Singapore medical journal. 2009; 139.

    • Parganiha, R., Mishra, J., Deshmukh, V. S., Muley, B. P., Sawarkar, H. A., & Kashyap, P. In-vitro anti-asthmatic activity of fruit extract of Sapindus mukorossi. International Journal Herbal Drug Research. 2011; 11-14.

    • Li, S., Wang, C., Wang, M., Li, W., Matsumoto, K., & Tang, Y. Antidepressant like effects of piperine in chronic mild stress treated mice and its possible mechanisms. Life sciences. 2007; 1373-1381.

    • Matsuda, H., Ninomiya, K., Morikawa, T., Yasuda, D., Yamaguchi, I., & Yoshikawa, M. Protective effects of amide constituents from the fruit of Piper chaba on d-galactosamine/TNF-α-induced cell death in mouse hepatocytes. Bioorganic & medicinal chemistry letters. 2008; 2038-2042.

    • Johnson, J. J., Nihal, M., Siddiqui, I. A., Scarlett, C. O., Bailey, H. H., Mukhtar, H., & Ahmad, N. Enhancing the bioavailability of resveratrol by combining it with piperine. Molecular nutrition & food research. 2011; 1169-1176.

    • Wattanathorn, J., Chonpathompikunlert, P., Muchimapura, S., Priprem, A., & Tankamnerdthai, O. Piperine, the potential functional food for mood and cognitive disorders. Food and Chemical Toxicology. 2008; 3106-3110.

    • Majeed, M., Badmaev, V., & Rajendran, R. U.S. Patent No. 5,972,382. Washington, DC: U.S. Patent and Trademark Office 1999.

    • Vijayakumar, R., Surya, D., & Nalini, N. Antioxidant efficacy of black pepper (Piper nigrum L.) and piperine in rats with high fat diet induced oxidative stress. Redox Report.2004; 105-110.

    • Ahmad, N., Fazal, H., Abbasi, B. H., Rashid, M., Mahmood, T., & Fatima, N. (). Efficient regeneration and antioxidant potential in regenerated tissues of Piper nigrum L. Plant Cell, Tissue and Organ Culture (PCTOC). 2010; 129-134.

    • Ahmad, N., Fazal, H., Abbasi, B. H., Farooq, S., Ali, M., & Khan, M. A. (). Biological role of Piper nigrum L.(Black pepper): A review. Asian Pacific Journal of Tropical Biomedicine. 2012; S1945-S1953.

    • Hritcu, L., Noumedem, J. A., Cioanca, O., Hancianu, M., Kuete, V., & Mihasan, M. Methanolic extract of Piper nigrum fruits improves memory impairment by decreasing brain oxidative stress in amyloid beta (1–42) rat model of Alzheimer’s disease. Cellular and molecular neurobiology. 2014; 437-449.

    • Agbor, G. A., Akinfiresoye, L., Sortino, J., Johnson, R., & Vinson, J. A. Piper species protect cardiac, hepatic and renal antioxidant status of atherogenic diet fed hamsters. Food Chemistry. 2012; 1354-1359.

    • Selvendiran, K., & Sakthisekaran, D. Chemopreventive effect of piperine on modulating lipid peroxidation and membrane bound enzymes in benzo (a) pyrene induced lung carcinogenesis. Biomedicine & pharmacotherapy. 2004; 264-267.

    • Doucette, C. D., Hilchie, A. L., Liwski, R., & Hoskin, D. W. Piperine, a dietary phytochemical, inhibits angiogenesis. The Journal of nutritional biochemistry. 2013; 231-239.

    • Makhov, P., Golovine, K., Canter, D., Kutikov, A., Simhan, J., Corlew, M. M., ... & Kolenko, V. M. Co‐administration of piperine and docetaxel results in improved anti‐tumor efficacy via inhibition of CYP3A4 activity. The prostate. 2012; 661-667.

    • Samykutty, A., Shetty, A. V., Dakshinamoorthy, G., Bartik, M. M., Johnson, G. L., Webb, B., ... & Munirathinam, G. Piperine, a bioactive component of pepper spice exerts therapeutic effects on androgen dependent and androgen independent prostate cancer cells. PLoS One. 2013; e65889.

    • Bang, J. S., Oh, D. H., Choi, H. M., Sur, B. J., Lim, S. J., Kim, J. Y., ... & Kim, K. S. Anti-inflammatory and antiarthritic effects of piperine in human interleukin 1β-stimulated fibroblast-like synoviocytes and in rat arthritis models. Arthritis research & therapy. 2009; 11, 1-9.

    • Nahak, G., & Sahu, R. K. Phytochemical evaluation and antioxidant activity of Piper cubeba and Piper nigrum. Journal of Applied Pharmaceutical Science, (Issue). 2011; 153-157.

    • Trease G.E., Evans W.C. Pharmacognosy, 12th edn. Bailliere Tindall, East Bourne, 1983.

    • Mukherjee, P. K. Quality control of herbal drugs: an approach to evaluation of botanicals. Business horizons 2002.

    • Pharmacopoeia, I. Government of India Ministry of Health and Family Welfare, published by Controller of publication. New Delhi. 1996; 736.

    • Harborne, A. J. Phytochemical methods a guide to modern techniques of plant analysis. springer science & business media 1998.

    • Kim, K. T., Yoo, K. M., Lee, J. W., Eom, S. H., Hwang, I. K., & Lee, C. Y. Protective effect of steamed American ginseng (Panax quinquefolius L.) on V79-4 cells induced by oxidative stress. Journal of ethnopharmacology. 2007; 443-450.

    • Blois, M. S. Antioxidant determinations by the use of a stable free radical. Nature. 1958; 1199-1200.

    • Sies, H., & Stahl, W. Vitamins E and C, beta-carotene, and other carotenoids as antioxidants. The American journal of clinical nutrition. 1995; 1315S-1321S.

    • Pietta, P. G. Flavonoids as antioxidants. Journal of natural products. 2000; 1035-1042.

    • Vani, T., Rajani, M., Sarkar, S., & Shishoo, C. J. Antioxidant properties of the ayurvedic formulation triphala and its constituents. International Journal of Pharmacognosy. 1997; 313-317.

    • Atal, C. K., Dubey, R. K., & Singh, J. Biochemical basis of enhanced drug bioavailability by piperine: evidence that piperine is a potent inhibitor of drug metabolism. Journal of Pharmacology and Experimental Therapeutics. 1985; 258-262.

    • Abayomi, S. Medicinal plants and traditional medicine in Africa. J Altern Complement Med. (1993; 195-238.

    • Rice-Evans, C., Miller, N., & Paganga, G. Antioxidant properties of phenolic compounds. Trends in plant science. 1997; 152-159.

    • Prior, R. L., & Cao, G. Antioxidant phytochemicals in fruits and vegetables: diet and health implications. HortScience. 2000; 588-592.

    • Demiray, S., Pintado, M. E., & Castro, P. M. L. Evaluation of phenolic profiles and antioxidant activities of Turkish medicinal plants: Tiliaargentea, Crataegi folium leaves and Polygonum bistorta roots. International Journal of Pharmacological and Pharmaceutical Sciences. 2009; 74-79.

    • Cai, Y., Luo, Q., Sun, M., & Corke, H. Antioxidant activity and phenolic compounds of 112 traditional Chinese medicinal plants associated with anticancer. Life sciences. 2004; 2157-2184.

    • Pokorny, J., Yanishlieva, N., & Gordon, M. H. (Eds.). Antioxidants in food: practical applications. CRC press 2001.

    • Maisuthisakul, P., Suttajit, M., & Pongsawatmanit, R. Assessment of phenolic content and free radical-scavenging capacity of some Thai indigenous plants. Food chemistry. 2007; 1409-1418.

    • Brand-Williams, W., Cuvelier, M. E., & Berset, C. L. W. T. Use of a free radical method to evaluate antioxidant activity. LWT-Food science and Technology. 1995; 25-30.

    • Katalinić, V., Milos, M., Modun, D., Musić, I., & Boban, M. Antioxidant effectiveness of selected wines in comparison with (+)-catechin. Food chemistry. 2004; 593-600.

    • Koleva, I. I., Van Beek, T. A., Linssen, J. P., Groot, A. D., & Evstatieva, L. N. Screening of plant extracts for antioxidant activity: a comparative study on three testing methods. Phytochemical Analysis: An International Journal of Plant Chemical and Biochemical Techniques. 2002; 8-17.

    • Yen, G. C., & Chen, H. Y. Antioxidant activity of various tea extracts in relation to their antimutagenicity. Journal of agricultural and food chemistry. 1995; 27-32.

    • Karadeniz, F., Burdurlu, H. S., Koca, N., & Soyer, Y. Antioxidant activity of selected fruits and vegetables grown in Turkey. Turkish Journal of Agriculture and Forestry. 2005; 297-303.

    • Yen, G. C., & Chen, H. Y. Antioxidant activity of various tea extracts in relation to their antimutagenicity. Journal of agricultural and food chemistry. 1995; 27-32.

    • Katsube, T., Tabata, H., Ohta, Y., Yamasaki, Y., Anuurad, E., Shiwaku, K., & Yamane, Y. Screening for antioxidant activity in edible plant products: comparison of low-density lipoprotein oxidation assay, DPPH radical scavenging assay, and Folin− Ciocalteu assay. Journal of agricultural and food chemistry. 2004; 2391-2396.

    Share This Chapter!