Release Date: 2024-06-07

Medicinal Effects of Valeriana Officinalis Extract on Living Organisms

Mikail Ozcan (Author), Gokhan Alagoz (Author)

Release Date: 2024-06-07

Abstract: Algae, which are of great importance for the marine ecosystem, are also rich in high-value bioactive compounds. These valuable bioactive compounds are fat and fatty acids, proteins, carbohydrates (sugars), pigments, minerals, vitamins, sterols, antioxidants and polyphenols. With the industrial production of these compounds, their areas of use are expanding day by day. Some bioactive [...]

Media Type
    Buy from

    Price may vary by retailers

    Abstract: Algae, which are of great importance for the marine ecosystem, are also rich in high-value bioactive compounds. These valuable bioactive compounds are fat and fatty acids, proteins, carbohydrates (sugars), pigments, minerals, vitamins, sterols, antioxidants and polyphenols. With the industrial production of these compounds, their areas of use are expanding day by day. Some bioactive compounds with the highest industrial production and utilization and their commercial dimensions have been evaluated.

    Mikail Ozcan (Author)
    Kahramanmaraş Sütçü İmam University
    https://orcid.org/0000-0001-9032-0697
    3Kahramanmaras Sutcu Imam University, Agriculture Faculty, Department of Animal Science, Kahramanmaras, 46040 Turkey

    Gokhan Alagoz (Author)
    Kahramanmaraş Sütçü İmam University
    https://orcid.org/0000-0002-8361-4926
    3Kahramanmaras Sutcu Imam University, Agriculture Faculty, Department of Animal Science, Kahramanmaras, 46040 Turkey

    • Hadley, S., & Petry, J.J. (2003). Valerian. American Family Physician, 67: 1755-1758. 2.

    • Andreatini, R., Sartori, V.A., Seabra, M.L., & Leite, J.R. (2002). Effect of valepotriates (valerian extract) in generalized anxiety disorder: A randomized placebo- controlled pilot study. Phytotherapy Research, 16: 650-654.

    • Letchamo, W., Ward, W., Heard, B., & Heard, D. (2004). Essential oil of Valeriana officinalis L. Cultivars and their antimicrobial activity as influenced by harvesting time under commercial organic cultivation. Journal of Agricultural Food Chemistry, 52 (12): 39153919.

    • Neamati, A., Chaman, F., Hosseini, M., & Boskabady, M.H. (2014). The effects of Valeriana officinalis L. hydro-alcoholic extract on depression like behavior in ovalbumin sensitized rats. Journal of Pharmacy and Bioallied Sciences, 6(2): 97-103.

    • Circosta, C., De Pasquale, R., Samperi, S., Pino, A., & Occhiuto, F. (2007). Biological and analytical characterization of two extracts from Valeriana officinalis. Journal of Ethnopharmacology, 112: 361-367.

    • Malva, J.O., Santos, S., & Macedo, T. (2004). Neuroprotective properties of Valeriana officinalis extracts. Neurotoxicolgical Research, 6: 131-40.

    • Oliveira, D.M., Barreto, G., De Andrade, D.E.V., Saraceno, E., Aon-Bertolino, L., Capani, F., El Bacha, R.S., & Giraldez, L.D. (2009). Cytoprotective effect of Valeriana officinalis extract on in vitro experimental model of Parkinson disease. Neurochemical Research, 34: 215-220.

    • Sudati, J.H., Fachinetto, R., Pereira R.P., Boligon, A.A., Athayde, M.L., Soares, F.A., De Vargas Barbosa, N.B., & Teixeira Rocha J.B. (2009). In vitro antioxidant activity of Valeriana officinalis against different neurotoxic agents. Neurochemical Research, 34: 1372-1379.

    • Jugran, A.K., Bahukhandi, A., Dhyani, P., Bhatt, I.D., Rawal, R.S., Nandi, S.K., & Palni, L.M.S. 2015. The effect of inoculation with mycorrhiza: AM on growth, phenolics, tannins, phenolic composition and antioxidant activity in Valeriana jatamansi Jones. Journal of Soil Science and Plant Nutrition, 15(4): 10351049.

    • Pereira, R.P., Fachinetto, R., Prestes, A.S., Puntel, R.L., Silva, G.N.S., Heinzmann, B.M., Boschetti, T.K., Athayde, M.L., Burger, M.E., Morel, A.F., Morsh, V.M., & Rocha, J.B.T. (2009). Antioxidant effects of different extracts from Melissa officinalis, Matricaria recutita and Cymbopogon citrates. Neurochemical Research, 34: 973-983.

    • Grive, M. (1967). A Modern Herbal, yol. II, 824830, Hafner Publishing Co. New Yol* and Londön

    • Chapelle, J.P., & Dencel A. (1972). Valepotriates in V. officinalis roots. Plant. Med. Phaytother, 6, (2), 91 -105.

    • Baytop, T. (1963). Türkiye’nin Tıbbi ve Zehirli Bitkileri. İstanbul

    • Baytop, T. (1984). Türkiye’de Bitkilerle Tedavi, İstanbul Üniversitesi Yayın No:3255, İstanbul,

    • Aronson, J. K. (2009).Meyler’s Side Effects of Herbal Medicines, Elsevier,

    • WHO, (1999). Monographs, WHO Monographs on Selected Medicinal Plants, Volume 1, 267-276, World Health Organization, Geneva,

    • Karamanoğlu, K., & Koyuncu, M. (1974). Türkiye Valeriana (Kedinin) Türleri Üzerinde Sistematik Araştırmalar. Ankara Ecz. Fa. Mec. 4,149.

    • Dindaroğlu T., Önal M., & Reis A. (2014). III. Uluslararası Odun Dışı Orman Ürünleri Sempozyumu 8-10 Mayıs 2014, Kahramanmaraş

    • Barnes, J., Anderson, L. A., & Phillipson, J. D. (2007). Herbal Medicines 3rd ed., Pharmaceutical Press, London,

    • Patocka, J., & Jakl, J. (2010). Biomedically relevant chemical constituents of Valeriana officinalis, Journal of Applied Biomedicine, 8(1): 11-18.

    • Gao, X. Q., & Björk, J. (2000).Valerenic acid derivetives and valepotriates among individuals, varieties and species of Valeriana, Fitoterapia, 71, 19-24.

    • PDR, (2007). for Herbal Medicines, 4th ed., Thomson Medical Economics, Montvale NJ,

    • EMA, (2015). European Union herbal monograph on Valeriana officinalis L., radix EMA/HMPC/150848/2015.

    • Khan, I. A., & Abourashed, E. A. (2010). Leung’s Encyclopedia of Common Natural Ingredients: Used in Food, Drugs and Cosmetics,Third edition, pp 612-615.

    • Hattesohl, M., Feistel, B., Sievers, H., Lehnfeld, R., Hegger, M., & Winterhoff, H. (2008). Extracts of Valeriana officinalis L. s.l. show anxiolytic and antidepressant effects but neither sedative nor myorelaxant properties, Phytomedicine, 15, 2–15.

    • Torres-Hernández, B. A., Del Valle-Mojica, L. M., & Ortíz, J. G. (2015). Valerenic acid and Valeriana officinalis extracts delay onset of Pentylenetetrazole (PTZ)-Induced seizures in adult Danio rerio (Zebrafish). BMC Complementary and Alternative Medicine, 15(1), 228.

    • Del Valle-Mojica, L. M., Ayala-Marin, Y. M., Ortiz-Sanchez, C. M., Torres-Hernandez, B. A., Abdalla-Mukhaimer, S., & Ortiz, J. G. (2011a). Selective Interactions of Valeriana officinalis Extracts and Valerenic Acid with [3H]Glutamate Binding to Rat Synaptic Membranes, Evidence-Based Complementary and Alternative Medicine, Article ID 403591, 7.

    • Del Valle-Mojica, L. M., Cordero-Hernandez, J. M., Gonzalez-Medina, G., Ramos-velez, I., Berrios-Cartegena, N., Torres-Hernandez B. A., & Ortiz, J. G. (2011b). Aqueous and Ethanolic Valeriana officinalis Extracts Change the Binding of Ligands to Glutamate Receptors, Evidence-Based Complementary and Alternative Medicine, Article ID 891819, 7.

    • Gromball, J., Beschorner, F., Wantzen, C., Paulsen, U., & Burkart, M., (2014). Hyperactivity, concentration difficulties and impulsiveness improve during seven weeks’ treatment with valerian root and lemon balm extracts in primary school children, Phytomedicine, 21(8): 1098-1103.

    • Aydınoğlu, Ü., Özcan, H., Yücel, A., Yücel, N., & Mutlu, M. (2012). Valerian Induced Hypomania: A Case Report. Bulletin of Clinical Psychopharmacology, 22(1): 63.

    • Hassani, S., Alipour, A., Khezri, H. D., Firouzian, A., Zeydi, A. E., Baradari, A. G., Ghafari, R., Habibi, W-A, Tahmasebi, H., Alipour F., & Zadeh, P. E. (2015). Can Valeriana officinalis root extract prevent early postoperative cognitive dysfunction after CABG surgery? A randomized, double-blind, placebo-controlled trial. Psychopharmacology, 232(5): 843-850,

    • Yoo, D. Y., Jung, H. Y., Nam, S. M., Kim, J. W., Choi, J. H., Kwak, Y-G, Yoo, M., Lee, S., Yoon, Y. S., & Hwang, I. K. (2015). Valeriana officinalis extracts ameliorate neuronal damage by suppressing lipid peroxidation in the gerbil hippocampus following transient cerebral ischemia. Journal of medicinal food, 18(6), 642-647.

    • Jung, H. Y., Yoo, D. Y., Kim, W., Nam, S. M., Kim, J. W., Choi, J. H., Kwak, Y.G., Yoon, Y. S., & Hwang, I. K. (2014). Valeriana officinalis root extract suppresses physical stress by electric shock and psychological stress by nociceptive stimulation-evoked responses by decreasing the ratio of monoamine neurotransmitters to their metabolites. BMC Complementary and Alternative Medicine, 14(1), 476, 1-8.

    • Pinheiro, M. L. P., Alcântara, C. E. P., de Moraes, M., & De Andrade, E. D. (2014). Valeriana officinalis L. for conscious sedation of patients submitted to impacted lower third molar surgery: A randomized, double-blind, placebo-controlled splitmouth study. Journal of Pharmacy Bioallied Sciences, 6(2): 109-114.

    • Bent, S., Padula, A., Moore, D., Patterson, M., & Mehling, W. (2006). Valerian for sleep: a systematic review and meta-analysis. The American journal of medicine, 119(12), 1005–1012.

    • Rosick, E. R. (2014).The Use of Supplements, Herbs, and Alternative Therapies in the Treatment of İnsomnia. Osteopathic Family Physician, 6(2), 14-18.

    • Willey, L.B., Mady, S.P., Cobaugh, D.J., & Wax, P.M. (1995). Valerian overdose: a case report. Veterinary and Human Toxicology, 37(4): 364-365.

    • Chan, T.Y.K., Tang, C.H., & Critchley, A.J.H. (1995). Poisoning due to an over-thecounter hypnotic, Sleep-Qik (hyoscine, cyproheptadine, valerian), Postgraduate Medical Journal, 71(834): 227-228.

    • Herbalist Upton, R. 1999. Valerian Root., American Herbal Pharmacopoeia and Therapeutic Compendium.

    • Hui-lian, W., Dong-fang, Z., Zhao-feng, L., Yang, L., Qian-rong, L., & Yu-zhen, W. (2003). In vitro study on the genotoxicity of dichloromethane extracts of valerian (DEV) in human endothelial ECV304 cells and the effect of vitamins E and C in attenuating the DEVinduced DNA damages. Toxicology and Applied Pharmacology, 188, 36–41.

    • Al-Majed, A.A., Al-Yahya, A.A., Al-Bekairi, A.M., Al-Shabanah, O.A., & Qureshi, S. (2006). Studies on the cytological and biochemical effects of valerian in somatic and germ cells of Swiss albino mice. Food and Chemical Toxicology, 44:1830–1837.

    • Mills, E., Duguoa, J.J., Perri, D., & Koren, G. (2006). Herbal Medicines in Pregnancy and Lactation, An Evidence-Based Approach, Taylor & Francis Group, London.

    • Yao, M., Ritchie, H.E., & Brown-Woodman, P.D. (2007). A developmental toxicity-screening test of valerian. Journal of Ethnopharmacology, 113, 204–209.

    • Tracy, T. S., & Kingston, R. L. (2007). Herbal Products: Toxicology and Clinical Pharmacology, 2: 5570.

    • Ahmadi, M., Khalili, H., Abbasian, L., & Ghaeli, P. (2017). Effect of Valerian in Preventing Neuropsychiatric Adverse Effects of Efavirenz in HIV-Positive Patients: A Pilot Randomized, Placebo-Controlled Clinical Trial. Ann Pharmacother. 51(6): 457-464.

    • Aslan, S. (2003). Valeriana phu L.’nin Terpenik Bileşikleri Üzerinde Çalışmalar, Ankara Üniversitesi Sağlık Bilimleri Enstitüsü. Yüksek Lisans Tezi Ankara.

    • Varel, M. (2011). “FFD Monografları “pp. 709-716.

    • Aliakbari, F., & Rafieian, M. (2018). The effectiveness of Valeriana officinalis on sleep disturbance in patients with chronic heart failure. International Journal of Pharmaceutical Investigation, 8(3), 145-145.

    Share This Chapter!