The pathology of sarcoidosis offers critical insights into the structural and cellular changes that define this enigmatic disease. This chapter explores the characteristic features observed in affected tissues, emphasizing the formation of granulomas—organized clusters of immune cells—as a hallmark pathological finding. These granulomas can affect virtually any organ, with the lungs and lymph nodes being commonly involved sites. Beyond their mere presence, the chapter delves into the diversity of granuloma types, variations in their composition, and the associated tissue responses that contribute to disease progression and clinical outcomes.