Release Date: 2023-09-14

The Role of Ion Channels in Diabetes Mellitus

Abdulhadi Cihangir Uguz (Author)

Release Date: 2023-09-14

The role of ion channels in diabetes mellitus encompasses their critical involvement in regulating cellular functions central to glucose metabolism and insulin secretion. Ion channels, such as potassium (K+) channels and calcium (Ca2+) channels, play pivotal roles in pancreatic beta cells where they govern insulin secretion in response to changes in blood glucose levels. ATP-sensitive [...]

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Work TypeBook Chapter
Published inCurrent Multidisciplinary Approach to Diabetes Mellitus Occurrence Mechanism
First Page115
Last Page132
DOIhttps://doi.org/10.69860/nobel.9786053359104.11
ISBN978-605-335-910-4 (PDF)
LanguageENG
Page Count18
Copyright HolderNobel Tıp Kitabevleri
Licensehttps://nobelpub.com/publish-with-us/copyright-and-licensing

The role of ion channels in diabetes mellitus encompasses their critical involvement in regulating cellular functions central to glucose metabolism and insulin secretion. Ion channels, such as potassium (K+) channels and calcium (Ca2+) channels, play pivotal roles in pancreatic beta cells where they govern insulin secretion in response to changes in blood glucose levels. ATP-sensitive K+ channels (KATP channels) mediate glucose-stimulated insulin secretion by modulating cell membrane potential and calcium influx, essential for triggering insulin release. Dysfunction or dysregulation of these ion channels, often influenced by genetic mutations or environmental factors like chronic hyperglycemia, can impair insulin secretion and contribute to the pathophysiology of diabetes mellitus. Moreover, ion channels in other tissues, such as vascular smooth muscle cells and neurons, are implicated in diabetic complications like cardiovascular disease and neuropathy. Research focusing on understanding ion channel physiology and pathology in diabetes aims to identify novel therapeutic targets for improving insulin secretion, glucose homeostasis, and overall management of diabetes-related complications.

Abdulhadi Cihangir Uguz (Author)
Associate Professor, Karamanoglu Mehmetbey University
https://orcid.org/0000-0002-5778-581X

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