Release Date: 2023-09-14

Effects of Diabetes Mellitus on Bone Quality

Mustafa Unal (Author)

Release Date: 2023-09-14

Diabetes mellitus significantly affects bone quality through multifaceted mechanisms that contribute to increased fracture risk and impaired bone strength. Individuals with diabetes often experience alterations in bone metabolism characterized by reduced bone formation and increased bone resorption, leading to lower bone mineral density (BMD) and compromised bone microarchitecture. Chronic hyperglycemia promotes the formation of advanced [...]

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Work TypeBook Chapter
Published inCurrent Multidisciplinary Approach to Diabetes Mellitus Occurrence Mechanism
First Page95
Last Page103
DOIhttps://doi.org/10.69860/nobel.9786053359104.9
ISBN978-605-335-910-4 (PDF)
LanguageENG
Page Count9
Copyright HolderNobel Tıp Kitabevleri
Licensehttps://nobelpub.com/publish-with-us/copyright-and-licensing

Diabetes mellitus significantly affects bone quality through multifaceted mechanisms that contribute to increased fracture risk and impaired bone strength. Individuals with diabetes often experience alterations in bone metabolism characterized by reduced bone formation and increased bone resorption, leading to lower bone mineral density (BMD) and compromised bone microarchitecture. Chronic hyperglycemia promotes the formation of advanced glycation end-products (AGEs), which accumulate in bone collagen and impair its mechanical properties. Moreover, insulin resistance and altered levels of circulating hormones such as insulin-like growth factor-1 (IGF-1) and osteocalcin disrupt the balance between bone formation and resorption processes. Additionally, diabetic complications such as peripheral neuropathy and microvascular disease contribute to impaired bone healing and osteoporotic fractures. The management of bone health in diabetes requires a comprehensive approach that includes optimizing glycemic control, promoting physical activity, ensuring adequate vitamin D and calcium intake, and monitoring bone health through regular assessment of BMD and fracture risk. Addressing these multifactorial aspects of bone quality in diabetes is essential to mitigate fracture risk and improve overall skeletal health outcomes.

Mustafa Unal (Author)
Associate Professor, Karamanoglu Mehmetbey University
https://orcid.org/0000-0002-9518-8952

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