Tuberculosis (TB) is the most common infectious disease that will cause death worldwide by 2022, apart from Covid-19. More than 10 million people are infected each year, and half of untreated cases can be fatal. TB usually affects the lungs and is transmitted through the air. Extrapulmonary TB develops in 25% of cases and usually occurs within 6-12 weeks of primary infection. Tuberculosis is a widespread health problem in low- and middle-income countries. Lymph node is the most common form of TB after tuberculosis. Tuberculosis pleurisy usually occurs as a complication of lung tuberculosis. The pleural cavity contains a small amount of fluid and is held in a constant volume by the lymphocytes in the pleural layers. Some untreated cases of lung tuberculosis can recover by themselves, while others can turn into extrapulmonary forms over time. Early diagnosis and treatment are important in preventing these conditions. The diagnosis highlights the importance of traditional methods such as tuberculin skin test (TDT) and measurement of ADA levels, as well as increased IFN-γ levels in recent years. A pleural biopsy is an important method to confirm the presence of granulomatous inflammation, which is to be specific to tuberculosis. In patients who do not respond to treatment or cannot rule out alternative diagnoses, therapeutic toracenthesis or drainage with pleural catheters may be required. In patients with pleurisy of locular tuberculosis, the use of intrapleuric fibrinolytic agents has been shown to have a positive effect on lung volume. Treatment lasts for at least six months and patients with symptomatic effusion can be drained with therapeutic toracenthesis or pleural catheters. The effect of corticosteroid use remains to be discussed. These methods enable a diagnosis and a faster and more effective treatment to be initiated.n