Release Date: 2024-03-07

Ensuring Functional Recovery After Radiothrapy

Mursel Duzova (Author)

Release Date: 2024-03-07

Radiotherapy, a cornerstone of cancer treatment, often leads to significant side effects that can impair a patient’s functional abilities and quality of life. This chapter explores the critical role of rehabilitation in mitigating these side effects and ensuring functional recovery and maintenance across various cancer types. Radiotherapy can cause a range of complications, including tissue [...]

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Work TypeBook Chapter
Published inOncological Rehabilitation a Handbook for Healthcare Professionals
First Page55
Last Page84
DOIhttps://doi.org/10.69860/nobel.9786053358893.3
ISBN978-605-335-889-3 (PDF)
LanguageENG
Page Count30
Copyright HolderNobel Tıp Kitabevleri
Licensehttps://nobelpub.com/publish-with-us/copyright-and-licensing
Radiotherapy, a cornerstone of cancer treatment, often leads to significant side effects that can impair a patient’s functional abilities and quality of life. This chapter explores the critical role of rehabilitation in mitigating these side effects and ensuring functional recovery and maintenance across various cancer types. Radiotherapy can cause a range of complications, including tissue fibrosis, muscle weakness, lymphedema, and cognitive deficits, necessitating a comprehensive rehabilitation approach. We begin by highlighting the necessity of rehabilitation for patients undergoing head and neck radiotherapy, where speech, swallowing, and facial functions are commonly affected. For brain radiotherapy, we emphasize cognitive rehabilitation and strategies to manage neurological deficits. Thoracic radiotherapy often impacts respiratory and cardiac functions, making pulmonary rehabilitation essential for restoring lung capacity and overall cardiovascular health. Breast radiotherapy can lead to shoulder dysfunction and lymphedema, necessitating specialized physical therapy interventions. Similarly, gastrointestinal radiotherapy requires targeted rehabilitation to manage bowel dysfunction and nutritional issues. Gynecological and urinary system radiotherapies present unique challenges such as pelvic floor dysfunction, requiring tailored therapeutic exercises and interventions. Hematologic diseases treated with radiotherapy often result in systemic side effects, and sarcoma treatments necessitate comprehensive musculoskeletal rehabilitation. For Kaposi sarcoma, rehabilitation focuses on managing skin lesions and associated mobility issues. Endocrine and ocular system radiotherapies require specialized approaches to address hormonal imbalances and visual impairments, respectively. By detailing the specific rehabilitation needs for each type of radiotherapy, this chapter underscores the importance of an individualized rehabilitation plan to enhance recovery, maintain functionality, and improve the overall quality of life for cancer patients. The integration of rehabilitation into the cancer care continuum is essential for addressing the multifaceted impacts of radiotherapy and ensuring optimal patient outcomes.

Mursel Duzova (Author)
Selcuk University
https://orcid.org/0000-0003-1036-2593
3After graduating from Çukurova University Faculty of Medicine in 2007, he started his career in medicine. After his graduation, he turned to medical specialization and successfully completed his specialization in Radiation Oncology at Istanbul University Cerrahpaşa Faculty of Medicine in 2015. During this period, he gained experience in the treatment of oncological patients with radiotherapy and took part in many scientific studies. In 2015, he was appointed to Selçuk University Faculty of Medicine as a Radiation Oncology specialist and started his academic career. Here, he took an active role in both clinical practices and academic studies. He made significant contributions by continuing his patient treatment, student education and research activities. In line with his academic success and contributions in 2021, Dr. Lecturer He was promoted to member. During his tenure at Selçuk University, he attended many national and international congresses, closely followed the developments in his field and published scientific articles. In 2024, he continued to progress in his academic career and was entitled to receive the title of Associate Professor. He currently works as an Associate Professor in the Department of Radiation Oncology at Selçuk University Faculty of Medicine and continues to provide the best treatment service to his patients and to train the radiation oncologists of the future. Additionally, he continues to contribute to the field of oncology by conducting scientific research.

  • Nguyen, N. P., et al. (2019). “The Impact of Dysphagia on Quality of Life After Head and Neck Cancer Treatment.” Otolaryngology–Head and Neck Surgery.

  • Van der Molen, L., et al. (2011). “Speech Outcomes Following Treatment for Advanced Head and Neck Cancer: A Review.” Head & Neck.

  • O’Sullivan, E. M., et al. (2011). “The Efficacy of Acupuncture in Treating Xerostomia in Patients with Head and Neck Cancer.” Evidence-Based Complementary and Alternative Medicine.

  • Dijkstra, P. U., et al. (2007). “Trismus in Head and Neck Cancer: Treatment After Radiotherapy.” British Journal of Oral and Maxillofacial Surgery.

  • McGarvey, A. C., et al. (2015). “The Role of Exercise in the Rehabilitation of Head and Neck Cancer Patients.” Cancer Nursing.

  • Brown, P. D., et al. (2013). “Neurocognitive Function After Radiotherapy for Brain Metastases in the NCCTG N0574 (Alliance) Randomized Controlled Trial.” Journal of Clinical Oncology.

  • Gehring, K., et al. (2014). “Effectiveness of Cognitive Rehabilitation for Improving Cognitive

  • Functioning in Glioma Patients.” Journal of Neuro-Oncology.

  • Hilari, K., et al. (2010). “Speech and Language Therapy for Aphasia Following Stroke.” Cochrane

  • Database of Systematic Reviews.

  • Ownsworth, T., et al. (2015). “The Impact of Rehabilitation on the Quality of Life in Patients with

  • Primary Brain Tumors.” Journal of Neuro-Oncology.

  • Spruit, M. A., et al. (2013). “An official American Thoracic Society/European Respiratory Society statement: key concepts and advances in pulmonary rehabilitation.” American Journal of Respiratory and Critical Care Medicine.

  • Mezzani, A., et al. (2012). “Aerobic exercise intensity assessment and prescription in cardiac rehabilitation: a joint position statement of the European Association for Cardiovascular Prevention and Rehabilitation, the American Association of Cardiovascular and Pulmonary Rehabilitation, and the Canadian Association of Cardiac Rehabilitation.” Journal of Cardiopulmonary Rehabilitation and Prevention.

  • Stubblefield, M. D., et al. (2010). “A review of the literature on physical therapy management of soft tissue shoulder disorders in the cancer patient.” Journal of Cancer Survivorship.

  • Mosher, C. E., et al. (2013). “Randomized trial of expressive writing for distressed metastatic breast cancer patients.” Psychology & Health.

  • DiSipio, T., Rye, S., Newman, B., & Hayes, S. (2013). Incidence of unilateral arm lymphoedema after breast cancer: a systematic review and meta-analysis. The Lancet Oncology, 14(6), 500- 515.

  • McNeely, M. L., Campbell, K., Ospina, M., Rowe, B. H., Dabbs, K., Klassen, T. P., & Courneya, K. S. (2010). Exercise interventions for upper-limb dysfunction due to breast cancer treatment: a systematic review and meta-analysis. CMAJ, 182(5), 343-351.

  • Koczwara, B., Scott, J., Walpole, E., & Nandurkar, H. (2013). Implementing a systematic approach to improving pain outcomes in cancer survivors. Journal of Clinical Oncology, 31(15_suppl), e20537-e20537.

  • Andersen, B. L., DeRubeis, R. J., Berman, B. S., Gruman, J., Champion, V. L., Massie, M. J., ... & Rowland, J. H. (2014). Screening, assessment, and care of anxiety and depressive symptoms in adults with cancer: an American Society of Clinical Oncology guideline adaptation. Journal of Clinical Oncology, 32(15), 1605-1619

  • Mustian, K. M., Alfano, C. M., Heckler, C., Kleckner, A. S., Kleckner, I. R., Leach, C. R., ... & Schwartz, A. L. (2017). Comparison of pharmaceutical, psychological, and exercise treatments for cancer-related fatigue: a meta-analysis. JAMA Oncology, 3(7), 961-968

  • Nguyen, N. P., Vinh-Hung, V., Baumert, B. G., Zamagni, A., Arenas, M., Motuzas, D., ... & Thariat, J. (2020). Rehabilitation for cancer dysphagia: a contemporary update. Cancer Radiothérapie, 24(3), 214-220.

  • Arends, J., Bachmann, P., Baracos, V., Barthelemy, N., Bertz, H., Bozzetti, F., ... & Zurcher, G. (2017). ESPEN guidelines on nutrition in cancer patients. Clinical Nutrition, 36(1), 11-48. Hauer-Jensen, M., Denham, J. W., & Andreyev, H. J. N. (2014). Radiation enteropathy—pathogenesis, treatment and prevention. Nature Reviews Gastroenterology & Hepatology, 11(8), 470-479.

  • Bo, K., Frawley, H. C., Haylen, B. T., Abramov, Y., Almeida, F. G., Berghmans, B., ... & Zimmern, P. E. (2017). An International Urogynecological Association (IUGA)/International Continence Society (ICS) joint report on the terminology for the conservative and nonpharmacological management of female pelvic floor dysfunction. Neurourology and Urodynamics, 36(2), 221-244.

  • Carter, J., Stabile, C., Gunn, A., & Sonoda, Y. (2013). The physical consequences of gynecologic cancer surgery and their impact on sexual, emotional, and quality of life issues. The Journal of Sexual Medicine, 10(Supplement 1), 21-34.

  • Paskett, E. D., Dean, J. A., Oliveri, J. M., & Harrop, J. P. (2012). Cancer-related lymphedema risk factors, diagnosis, treatment, and impact: a review. Journal of Clinical Oncology, 30(30), 3726-3733.

  • Andreyev, H. J., Davidson, S. E., Gillespie, C., Allum, W. H., & Swarbrick, E. (2012). Practice guidance on the management of acute and chronic gastrointestinal problems arising as a result of treatment for cancer. Gut, 61(2), 179-192.

  • Goode, P. S., Burgio, K. L., Johnson, T. M., Clay, O. J., Roth, D. L., Markland, A. D., ... & Redden, D. T. (2011). Behavioral therapy with or without biofeedback and pelvic floor electrical stimulation for persistent postprostatectomy incontinence: a randomized controlled trial. JAMA, 305(2), 151-159.

  • Pisters, L. L., Pisters, P. W., Malpica, A., Pettaway, C. A., & von Eschenbach, A. C. (2000). Pharmacologic and surgical management of radiation cystitis. Urology, 56(3), 370-378.

  • Zelefsky, M. J., Shasha, D., Branco, R. D., Kollmeier, M. A., Mechalakos, J., & Cohen, G. N. (2014).

  • Long-term outcomes after brachytherapy for clinically localized prostate cancer: results at 15-year follow-up. Journal of Clinical Oncology, 32(10), 1088-1095.

  • Kesler, S. R., Janelsins, M., Koovakkattu, D., Palesh, O., Mustian, K., Morrow, G. R., & Dhabhar, F. S. (2013). Reduced hippocampal volume and verbal memory performance associated with interleukin-6 and tumor necrosis factor-alpha levels in chemotherapy-treated breast cancer survivors. Brain, Behavior, and Immunity, 30, S109-S116.

  • Garst, J. L., Herndon, J. E., & Rosenman, J. G. (2004). The role of pulmonary rehabilitation in the management of patients with radiation-induced lung disease. Chest, 125(2), 889-895.

  • Delanian, S., & Lefaix, J. L. (2004). The radiation-induced fibroatrophic process: therapeutic perspective via the antioxidant pathway. Radiotherapy and Oncology, 73(2), 119-131.

  • Baumann, F. T., Bloch, W., & Beulertz, J. (2012). Clinical exercise interventions in prostate cancer patients—a systematic review of randomized controlled trials. Supportive Care in Cancer, 20(2), 221-233.

  • Lasinski, B. B., Thrift, K. M., Squire, D., Austin, M. K., Smith, K. M., Wanchai, A., ... & Stewart, B. R. (2012). A systematic review of the evidence for complete decongestive therapy in the treatment of lymphedema from 2004 to 2011. PM&R, 4(8), 580-601.

  • Bennett, M. I., Eisenberg, E., Ahmedzai, S. H., Bhaskar, A., O’Brien, T., & Mercadante, S. (2019).

  • Standards for the management of cancer-related pain across Europe—A position paper from the EFIC Task Force on Cancer Pain. European Journal of Pain, 23(4), 660-668.

  • Coleman, R. E., Croucher, P. I., & Padhani, A. R. (2020). Bone metastases. Nature Reviews Disease Primers, 6(1), 83.

  • Naylor, W., Mallett, J., Petheram, T., & Morris, C. (2011). Wound care in radiotherapy. Wounds UK, 7(1), 30-38.

  • Jonklaas, J., Bianco, A. C., Bauer, A. J., Burman, K. D., Cappola, A. R., Celi, F. S., ... & Sawka, A. M. (2014). Guidelines for the treatment of hypothyroidism: prepared by the American Thyroid Association Task Force on Thyroid Hormone Replacement. Thyroid, 24(12), 1670-1751

  • Rushworth, R. L., Torpy, D. J., Falhammar, H., & Reade, M. C. (2020). Adrenal crisis. New England Journal of Medicine, 383(25), 2549-2560.

  • Tritos, N. A., Biller, B. M., & Swearingen, B. (2019). Management of nonfunctioning pituitary adenomas (NFAs): observation. Pituitary, 22(2), 217-224

  • Compston, J., Cooper, A., Cooper, C., Gittoes, N., Gregson, C., Harvey, N., ... & Reid, D. M. (2019).

  • UK clinical guideline for the prevention and treatment of osteoporosis. Archives of Osteoporosis, 14(1), 1-32

  • van Agteren, J., Iasiello, M., Lo, L., Bartholomaeus, J., Kopsaftis, Z., Carey, M., & Kyrios, M. (2021). A systematic review and meta-analysis of psychological interventions to improve mental wellbeing. Nature human behaviour, 5(5), 631-652.

  • Pult, H., Purslow, C., & Murphy, P. J. (2015). The relationship between clinical signs and dry eye symptoms. Eye & contact lens, 41(3), 146-154.

  • Virgili, G., Acosta, R., Bentley, S. A., Giacomelli, G., & Allcock, C. (2018). Reading aids for adults with low vision. Cochrane Database of Systematic Reviews, (4).

  • Finger, P. T., Chin, K. J., Yu, G. P., Chen, Y. T., & Ghazi, N. G. (2019). Intravitreal anti-VEGF therapy for macular radiation retinopathy: A 10-year study. European Journal of Ophthalmology, 29(1), 80-87.

  • Almeida, D. R., Chin, E. K., & Tarantola, R. M. (2020). Psychosocial interventions for adults with visual impairments. Cochrane Database of Systematic Reviews, (7).

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