Release Date: 2024-03-07

Pregnancy and Birth in Cancer Patients

Serife Irem Doner (Author), Meltem Ugurlu (Author)

Release Date: 2024-03-07

Cancer is the second leading cause of death in women of reproductive age. Pregnancy and birth in women with cancer is a psychologically, physiologically and medically sensitive issue. This book chapter deals with the diagnostic and therapeutic approaches that should be followed in women diagnosed with cancer and experiencing pregnancy, birth and postpartum period. Diagnosis [...]

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Work TypeBook Chapter
Published inOncological Rehabilitation a Handbook for Healthcare Professionals
First Page189
Last Page206
DOIhttps://doi.org/10.69860/nobel.9786053358893.9
ISBN978-605-335-889-3 (PDF)
LanguageENG
Page Count18
Copyright HolderNobel Tıp Kitabevleri
Licensehttps://nobelpub.com/publish-with-us/copyright-and-licensing
Cancer is the second leading cause of death in women of reproductive age. Pregnancy and birth in women with cancer is a psychologically, physiologically and medically sensitive issue. This book chapter deals with the diagnostic and therapeutic approaches that should be followed in women diagnosed with cancer and experiencing pregnancy, birth and postpartum period.
Diagnosis and treatment of cancers during pregnancy should be carefully planned according to trimesters in terms of both maternal and foetal health. Chemotherapy and radiotherapy in the first trimester are usually delayed because they may have teratogenic effects on the foetus. In the second and third trimesters, some chemotherapy drugs can be used more safely and uterine evacuation and hysterectomy can be performed.
Birth planning is also of special importance in women with cancer who are still pregnant. Premature delivery is avoided because of the high morbidity probability. However, preterm delivery can be planned in order to minimise the time without treatment and to prevent deterioration of the mother’s health status. Vaginal delivery is contraindicated for most cervical and vulvar cancers due to the potential for implantation of cancer cells into the vaginal laceration/episiotomy site. In addition, complications such as hysterectomy, blood transfusion, thromboembolism, sepsis may be seen in the mother during labour, while Apgar scores may decrease in the newborn and resuscitation may be needed.
In the postnatal period, breastfeeding is desirable for emotional attachment and as a healthy compensation for prenatal exposure to cancer treatment. However, the safety and feasibility of breastfeeding needs to be carefully assessed.
Psychosocial support during pregnancy, birth and postnatal periods in women with cancer strengthens the mother-infant relationship and contributes to the support of family formation.
In conclusion, pregnancy, birth and postpartum period in women with cancer is a complex process that requires a multidisciplinary approach and individualised treatment plans.
This chapter provides a detailed overview of the pathways to be followed and the points to be considered in the management of the association of cancer and pregnancy. Strategies for appropriate treatment and follow-up are emphasised to protect the health of both mother and baby.

Serife Irem Doner (Author)
Ankara Medipol University
https://orcid.org/0000-0002-0052-4133
3Research Assistant Serife Irem DONER completed master’s degree at the University of Health Sciences, Gülhane Institute of Health Sciences, Department of Midwifery in 2022 and completed master’s degree as the first graduate. She continues her doctorate education at the same university. Since 2023, she has been working as a research assistant at Ankara Medipol University, Faculty of Health Sciences, Department of Midwifery. The author has many national and international publications and book chapters in areas such as aromatherapy, pregnancy, traumatic birth, alternative therapies during labour, breastfeeding, menopause and social media. The author has many international papers.

Meltem Ugurlu (Author)
Saglık Bilimleri Universty
https://orcid.org/0000-0002-9183-219X
3Associate Prof. Meltem UGURLU completed her master’s degree at Gazi University in 2012 and her doctorate at Gülhane Military Medical Academy in 2016 about Gynecology and 0bstetrics Nursing. Since 2018, she has been working as a lecturer and deputy head of the Department of Midwifery, Gülhane Faculty of Health Sciences, University of Health Sciences. The author has many national and international publications and book chapters in areas such as risky pregnancies, breastfeeding, postpartum period, sexual health, gynecological cancers and breast cancer. The author has more than 100 internationally presented papers and awards. The author, who is currently a researcher in 6 COST Action projects, also has an ongoing TUSEB project on creative drama and birth preparation class.

  • Amant, F., Berveiller, P., Boere, I., Cardonick, E., Fruscio, R., Fumagalli, M., Halaska, M., Hasenburg, A., Johansson, A., & Lambertini, M. (2019). Gynecologic cancers in pregnancy: guidelines based on a third international consensus meeting. Annals of Oncology, 30(10), 1601- 1612.

  • Amant, F., Brepoels, L., Halaska, M. J., Gziri, M. M., & Van Calsteren, K. (2010). Gynaecologic cancer complicating pregnancy: an overview. Best Practice & Research Clinical Obstetrics & Gynaecology, 24(1), 61-79.

  • Amant, F., Han, S. N., Gziri, M. M., Vandenbroucke, T., Verheecke, M., & Van Calsteren, K. (2015). Management of cancer in pregnancy. Best Practice & Research Clinical Obstetrics & Gynaecology, 29(5), 741-753.

  • Amant, F., von Minckwitz, G., Han, S. N., Bontenbal, M., Ring, A. E., Giermek, J., Wildiers, H., Fehm, T., Linn, S. C., & Schlehe, B. (2013). Prognosis of women with primary breast cancer diagnosed during pregnancy: results from an international collaborative study. Journal of Clinical Oncology, 31(20), 2532-2539.

  • Azulay Chertok, I. R., Wolf, J. H., Beigelman, S., & Warner, E. (2020). Infant feeding among women with a history of breast cancer. Journal of Cancer Survivorship, 14, 356-362.

  • Brenner, B., Avivi, I., & Lishner, M. (2012). Haematological cancers in pregnancy. The Lancet, 379(9815), 580-587.

  • Carocha, A. I., Pedroso, C., Correia, L., Gomes, A., & Jorge, A. F. (2015). Glassy cell carcinoma of the cervix and metastasis in episiotomy scar: A case report. Journal of Lower Genital Tract Disease, 19(2), e31-e34.

  • Castanon, A., Landy, R., Pesola, F., Windridge, P., & Sasieni, P. (2018). Prediction of cervical cancer incidence in England, UK, up to 2040, under four scenarios: a modelling study. The Lancet Public Health, 3(1), e34-e43.

  • Cottreau, C. M., Dashevsky, I., Andrade, S. E., Li, D.-K., Nekhlyudov, L., Raebel, M. A., Ritzwoller, D. P., Partridge, A. H., Pawloski, P. A., & Toh, S. (2019). Pregnancy-associated cancer: a US population-based study. Journal of Women’s Health, 28(2), 250-257

  • Damoiseaux, D., Calpe, S., Rosing, H., Beijnen, J. H., Huitema, A. D., Lok, C., Dorlo, T. P., & Amant, F. (2022). Presence of five chemotherapeutic drugs in breast milk as a guide for the safe use of chemotherapy during breastfeeding: results from a case series. Clinical Pharmacology & Therapeutics, 112(2), 404-410.

  • de Haan, J., Verheecke, M., Van Calsteren, K., Van Calster, B., Shmakov, R. G., Gziri, M. M., Halaska, M. J., Fruscio, R., Lok, C. A., & Boere, I. A. (2018). Oncological management and obstetric and neonatal outcomes for women diagnosed with cancer during pregnancy: a 20- year international cohort study of 1170 patients. The Lancet Oncology, 19(3), 337-346.

  • Di Renzo, G. C., & Maulik, D. (2014).Maternal-Fetal Evidence Based Guidelines. (Eds:Elyce Cardonick)Chapter 42: Cancer, 373-385.

  • Durodola, J. I. (1979). Administration of cyclophosphamide during late pregnancy and early lactation: a case report. Journal of the National Medical Association, 71(2), 165.

  • Esposito, G., Franchi, M., Dalmartello, M., Scarfone, G., Negri, E., Parazzini, F., La Vecchia, C., & Corrao, G. (2021). Obstetric and neonatal outcomes in women with pregnancy associated cancer: a population-based study in Lombardy, Northern Italy. BMC Pregnancy and Childbirth, 21, 1-9.

  • Franciszek Dłuski, D., Mierzyński, R., Poniedziałek-Czajkowska, E., & Leszczyńska-Gorzelak, B. (2020). Ovarian cancer and pregnancy—A current problem in perinatal medicine: A Comprehensive Review. Cancers, 12(12), 3795.

  • Frisch, A., Walter, T. C., Hamm, B., & Denecke, T. (2017). Efficacy of oral contrast agents for upper gastrointestinal signal suppression in MRCP: A systematic review of the literature. Acta Radiologica Open, 6(9), 2058460117727315.

  • Greiber, I. K., Mikkelsen, A. P., Karlsen, M. A., Storgaard, L., Viuff, J., Mellemkjær, L., Hjortshøj, C. S., & Lidegaard, Ø. (2021). Cancer in pregnancy increases the risk of venous thromboembolism: a nationwide cohort study. BJOG: An International Journal of Obstetrics & Gynaecology, 128(7), 1151-1159.

  • Greiber, I. K., Viuff, J. H., Mellemkjær, L., Hjortshøj, C. S., Lidegaard, Ø., Storgaard, L., & Karlsen, M. A. (2022). Cancer in pregnancy and the risk of adverse pregnancy and neonatal outcomes: A nationwide cohort study. BJOG: An International Journal of Obstetrics & Gynaecology, 129(9), 1492-1502.

  • Griffin, S. J., Milla, M., Baker, T. E., Liu, T., Wang, H., & Hale, T. W. (2012). Transfer of carboplatin and paclitaxel into breast milk. Journal of Human Lactation, 28(4), 457-459.

  • Halaska, M., Komar, M., Vlk, R., Tomek, V., Skultety, J., Robova, H., & Rob, L. (2014). A pilot study on peak systolic velocity monitoring of fetal anemia after administration of chemotherapy during pregnancy. European Journal of Obstetrics & Gynecology and Reproductive Biology, 174, 76-79.

  • Halaska, M. J., Uzan, C., Han, S. N., Fruscio, R., Steffensen, K. D., Van Calster, B., Stankusova, H., Delle Marchette, M., Mephon, A., & Rouzier, R. (2019). Characteristics of patients with cervical cancer during pregnancy: a multicenter matched cohort study. An initiative from the International Network on Cancer, Infertility and Pregnancy. International Journal of Gynecologic Cancer, 29(4).

  • Han, S. N., Amant, F., Cardonick, E. H., Loibl, S., Peccatori, F. A., Gheysens, O., Sangalli, C. A., Nekljudova, V., Steffensen, K. D., & Mhallem Gziri, M. (2018). Axillary staging for breast cancer during pregnancy: feasibility and safety of sentinel lymph node biopsy. Breast cancer research and treatment, 168, 551-557.

  • Han, S. N., Verheecke, M., Vandenbroucke, T., Mhallem Gziri, M., Van Calsteren, K., & Amant, F. (2014). Management of gynecological cancers during pregnancy. Current oncology reports, 16, 1-10.

  • Ives, A., Musiello, T., & Saunders, C. (2012). The experience of pregnancy and early motherhood in women diagnosed with gestational breast cancer. Psycho‐Oncology, 21(7), 754-761.

  • Johnson, H. M., Mitchell, K. B., & Medicine, A. o. B. (2020). ABM clinical protocol# 34: breast cancer and breastfeeding. Breastfeeding Medicine, 15(7), 429-434.

  • Karbhari, N., & Thomas, A. A. (2022). Clinical management of brain tumors in pregnancy. Current Opinion in Oncology, 34(6), 691-697.

  • Khazzaka, A., Rassy, E., Sleiman, Z., Boussios, S., & Pavlidis, N. (2022). Systematic review of fetal and placental metastases among pregnant patients with cancer. Cancer Treatment Reviews, 104, 102356.

  • La Nasa, M., Gaughan, J., & Cardonick, E. (2019). Incidence of neonatal neutropenia and leukopenia after in utero exposure to c

  • Lee, Y., Roberts, C. L., Dobbins, T., Stavrou, E., Black, K., Morris, J., & Young, J. (2012). Incidence and outcomes of pregnancy‐associated cancer in Australia, 1994–2008: a population‐based linkage study. BJOG: An International Journal of Obstetrics & Gynaecology, 119(13), 1572- 1582.

  • Lishner, M., Avivi, I., Apperley, J. F., Dierickx, D., Evens, A. M., Fumagalli, M., Nulman, I., Oduncu, F. S., Peccatori, F. A., & Robinson, S. (2016). Hematologic malignancies in pregnancy: management guidelines from an international consensus meeting. Journal of Clinical Oncology, 34(5), 501-508.

  • Maggen, C., Wolters, V. E., Cardonick, E., Fumagalli, M., Halaska, M. J., Lok, C. A., de Haan, J., Van Tornout, K., Van Calsteren, K., & Amant, F. (2020). Pregnancy and cancer: the INCIP project. Current oncology reports, 22, 1-10.

  • Manuck, T. A., Rice, M. M., Bailit, J. L., Grobman, W. A., Reddy, U. M., Wapner, R. J., Thorp, J. M., Caritis, S. N., Prasad, M., & Tita, A. T. (2016). Preterm neonatal morbidity and mortality by gestational age: a contemporary cohort. American journal of obstetrics and gynecology, 215(1), 103. e101-103. e114.

  • Mayr, N. A., Wen, B.-C., & Saw, C. B. (1998). Radiation therapy during pregnancy. Obstetrics and Gynecology Clinics, 25(2), 301-321.

  • Mazzola, R., Corradini, S., Eidemüeller, M., Figlia, V., Fiorentino, A., Giaj-Levra, N., Nicosia, L., Ricchetti, F., Rigo, M., & Musola, M. (2019). Modern radiotherapy in cancer treatment during pregnancy. Critical Reviews in Oncology/Hematology, 136, 13-19.

  • Momen, N. C., Arendt, L. H., Ernst, A., Olsen, J., Li, J., Gissler, M., & Ramlau-Hansen, C. H. (2018). Pregnancy-associated cancers and birth outcomes in children: a Danish and Swedish population-based register study. BMJ open, 8(12), e022946.

  • Peccatori, F. A., Migliavacca Zucchetti, B., Buonomo, B., Bellettini, G., Codacci-Pisanelli, G., & Notarangelo, M. (2020). Lactation during and after Breast Cancer. Diseases of the Breast during Pregnancy and Lactation, 159-163.

  • Ray, J. G., Vermeulen, M. J., Bharatha, A., Montanera, W. J., & Park, A. L. (2016). Association between MRI exposure during pregnancy and fetal and childhood outcomes. Jama, 316(9), 952-961.

  • Rydzewska, L., Tierney, J., Vale, C. L., & Symonds, P. R. (2012). Neoadjuvant chemotherapy plus surgery versus surgery for cervical cancer. Cochrane Database of Systematic Reviews(12).

  • Sadler, N. C., Nandhikonda, P., Webb-Robertson, B.-J., Ansong, C., Anderson, L. N., Smith, J. N., Corley, R. A., & Wright, A. T. (2016). Hepatic cytochrome P450 activity, abundance, and expression throughout human development. Drug Metabolism and Disposition, 44(7), 984-991.

  • Samejima, K., Nagai, T., Kizaki, Y., Shigematsu, K., Kurose, Y., Uotani, T., Akahori, T., & Takai, Y. (2021). Vaginal cancer diagnosed during pregnancy presenting a therapeutic dilemma: A case report. Gynecologic Oncology Reports, 38, 100879.

  • Schwab, R., Anic, K., & Hasenburg, A. (2021). Cancer and pregnancy: A comprehensive review. Cancers, 13(12), 3048.

  • Siegel, R. L., Miller, K. D., & Jemal, A. (2019). Cancer statistics, 2019. CA: a cancer journal for clinicians, 69(1), 7-34.

  • Silverstein, J., Post, A. L., Chien, A. J., Olin, R., Tsai, K. K., Ngo, Z., & Van Loon, K. (2020). Multidisciplinary management of cancer during pregnancy. JCO Oncology Practice, 16(9), 545-557.

  • Sorouri, K., Loren, A. W., Amant, F., & Partridge, A. H. (2023). Patient-centered care in the management of cancer during pregnancy. American Society of Clinical Oncology Educational Book, 43, e100037.

  • Storgaard, L., Greiber, I. K., Pedersen, B. W., Nielsen, B. B., & Karlsen, M. A. (2024). Cancer in pregnancy—The obstetrical management. Acta Obstetricia et Gynecologica Scandinavica, 103(4), 630-635.

  • Surbone, A., Peccatori, F., & Pavlidis, N. (2008). Cancer and pregnancy. Springer.

  • Ugai, T., Sasamoto, N., Lee, H.-Y., Ando, M., Song, M., Tamimi, R. M., Kawachi, I., Campbell, P. T., Giovannucci, E. L., & Weiderpass, E. (2022). Is early-onset cancer an emerging global epidemic? Current evidence and future implications. Nature Reviews Clinical Oncology, 19(10), 656-673.

  • Van Westrhenen, A., Senders, J., Martin, E., DiRisio, A., & Broekman, M. (2018). Clinical challenges of glioma and pregnancy: a systematic review. Journal of Neuro-Oncology, 139, 1-11.

  • Webb, K. E., Sakhel, K., Chauhan, S. P., & Abuhamad, A. Z. (2015). Adnexal mass during pregnancy: a review. American journal of perinatology, 1010-1016.

  • World Health Organization (WHO). (2023). Infant and young child feeding. Available date:24.03.2024. Available at: https://www.who.int/news-room/fact-sheets/detail/infant-and-young-child-feeding.

  • Witzel, I., Müller, V., Harps, E., Janicke, F., & Dewit, M. (2008). Trastuzumab in pregnancy associated with poor fetal outcome. Annals of Oncology, 19(1), 191-192.

  • Wolters, V., Heimovaara, J., Maggen, C., Cardonick, E., Boere, I., Lenaerts, L., & Amant, F. (2021a). Management of pregnancy in women with cancer. International Journal of Gynecologic Cancer, 31(3).

  • Wolters, V. E., Lok, C. A., Gordijn, S. J., Wilthagen, E. A., Sebire, N. J., Khong, T. Y., van der Voorn, J. P., & Amant, F. (2021b). Placental pathology in cancer during pregnancy and after cancer treatment exposure. Placenta, 111, 33-46.

  • Xia, L.-Y., Hu, Q.-L., & Zhou, Q. (2021). Use of trastuzumab in treating breast cancer during pregnancy: a systematic review and meta-analysis. BMC Women’s Health, 21, 1-12.

  • Xu, T., Wang, L., Jia, Y., Jia, Z., Li, Z., Cui, S., & Cui, M. (2019). Long-term multidisciplinary integrative therapy management resulted in favorable outcomes for ovarian cancer during pregnancy: A case report and literature review. Journal of Ovarian Research, 12, 1-6.

  • Zagouri, F., Sergentanis, T. N., Chrysikos, D., Papadimitriou, C. A., Dimopoulos, M.-A., & Bartsch, R. (2013). Trastuzumab administration during pregnancy: a systematic review and meta-analysis. Breast cancer research and treatment, 137, 349-357.

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