In this section, we explore the outcomes of metastasectomy in prostate cancer patients. Systemic treatments for low-volume metastatic prostate cancer often lead to various side effects. However, in carefully selected cases, direct treatment methods such as metastasectomy or stereotactic body radiotherapy (SBRT) are used to control the disease in its early stages, providing an alternative to systemic treatments. Metastasectomy is particularly preferred for isolated metachronous metastases identified by PSMA PET scans.