Histology, the study of the microscopic structure of tissues, plays a critical role in complementary medicine by helping to understand the impact of various treatment modalities on tissue and organ systems. This paper explores the integration of histology with several complementary and alternative medicine (CAM) practices, including acupuncture, prolotherapy, phytotherapy, apitherapy, and ozone therapy. These treatments are widely utilized to address a range of health conditions, from chronic pain to metabolic disorders.Acupuncture involves inserting needles into specific body points and is analyzed histologically to evaluate its effects on nerve and muscle tissues. Prolotherapy, which involves injecting irritants to stimulate tissue repair, shows histological changes indicating enhanced tissue healing and regeneration. Phytotherapy, the use of plant-derived compounds, demonstrates varied histopathological effects, including anti-inflammatory and antioxidant properties that support tissue health.