Release Date: 2024-06-12

The Role of Vitamins in Brain Health

Ilhan Sabancilar (Author)

Release Date: 2024-06-12

The brain is one of the most complex organs of the body and requires proper nutrition to function healthily. Vitamins are organic compounds necessary for the normal metabolism of the body. There are many vitamins that regulate brain functions, and these are usually obtained from foods or supplements. The brain is a system that processes, [...]

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    Work TypeBook Chapter
    Published inBrain Biochemistry and Its Disease
    First Page65
    Last Page78
    DOIhttps://doi.org/10.69860/nobel.9786053359371.4
    Page Count14
    Copyright HolderNobel Tıp Kitabevleri
    Licensehttps://nobelpub.com/publish-with-us/copyright-and-licensing

    The brain is one of the most complex organs of the body and requires proper nutrition to function healthily. Vitamins are organic compounds necessary for the normal metabolism of the body. There are many vitamins that regulate brain functions, and these are usually obtained from foods or supplements. The brain is a system that processes, stores, integrates, or changes different pieces of information simultaneously. One of the fundamental purposes of the brain is to adapt to the environment. Therefore, the brain responds to changes and stimuli in its surroundings and creates new behaviors. Cognitive functions include various brain functions such as memory, learning, spatial orientation, reasoning, judgment and evaluation. The decline of these functions can lead to the emergence of certain chronic diseases. The brain responds to changes and stimuli in its surroundings and forms new behaviors.It is observed that these vitamins are crucial for the continued function of brain cells and the preservation of brain health. A balanced diet is important to ensure an adequate intake of these vitamins. Vitamins are organic compounds that are an essential part of a healthy lifestyle. Substances are divided into two groups: those soluble in water and those soluble in oil. In this compilation, we examined the effects of vitamins on brain health and their role in metabolism.

    Ilhan Sabancilar (Author)
    Assistant Professor, Bitlis Eren University
    https://orcid.org/0000-0002-0773-2752
    3Dr. İlhan SABANCILAR completed his undergraduate education in the fields of chemistry and biology. He earned his Master’s and Doctorate degrees in Biochemistry. After serving for 12 years in the Department of Biochemistry at Dicle University, he has been working as a Lecturer at Bitlis Eren University since 2023.

    • Clarke DD, Sokoloff L. Circulation and energy metabolism of the brain. In: Siegel, GJ, Agranoff BW, Albers RW, Molinoff SK, Fisher PB, Uhler MD, editors. Basic Neurochemistry. Philadelphia: LippincottRaven, 1999:637–69.

    • Leblebici, D. N. (2008). Örgüt kuramında paradigmalar ve metaforlar. Selçuk Üniversitesi İİBF Sosyal ve Ekonomik Araştırmalar Dergisi, 9(15), 345-360.

    • Morgan, G. (1998). Yönetim ve Örgüt Teorilerinde Metafor. (G. Bulut, Çev.) İstanbul: Türkiye Metal Sanayicileri Sendikası.

    • Williams, R., & Cline, J. (1936). Synthesis of vitamin B1. Journal of the American Chemical Society,Volume 58, Issue 8, 1504-1505.

    • Finglas, P. (1993). Thiamin. International Journal for Vitamin and Nutrition Research, Volume 63, Issue 4, 270-274.

    • Butterworth, R. (1987). Thiamine malnutrition and brain development. T Curr Top Nutr Dis, 287– 304.

    • Bettendorff, L., Peeters, M., Wins, P., & Schoffeniels, E. (1993). Metabolism of Thiamine Triphosphate in Rat Brain: Correlation with Chloride Permeability. Journal of Neurochemistry,Volume 60, Issue 2, 423-434.

    • Bourre, J. M. (2006). Effects of nutrients (in food) on the structure and function of the nervous system: update on dietary requirements for brain. Part 1: micronutrients. Journal of nutrition health and aging, 10(5), 377.

    • Bailey, A., Finglas, P., Wright, A., & Southon, S. (1994). Thiamin intake, erythrocyte transketolase (EC 2.2.1.1) activity and total erythrocyte thiamin in adolescents. British Journal of Nutrition Volume 72, Issue 1, 111-125.

    • Gibson, G. E., Hirsch, J. A., Fonzetti, P., Jordon, B. D., Cirio, R. T., & Elder, J. (2016). Vitamin B1 (thiamine) and dementia. Annals of the New York Academy of Sciences, 1367(1), 21

    • Ball, G. F., Wiley, J., & Sons. (2008). Vitamins: their role in the human body.

    • Baines, M., Bligh, J., & Madden, J. (1988). Tissue thiamin levels of hospitalised alcoholics before and after oral or parenteral vitamins. Alcohol and Alcoholism,Volume 23, Issue 1, 49-52.

    • Royer-Morrot, J., Zhiri, A., Paille, F., & Royer, R. (1992). Plasma thiamine concentrations after intramuscular and oral multiple dosage regimens in healthy men. European Journal of Clinical Pharmacology,Volume 42, Issue 2, 219-222.

    • Bingöl, G. (1977). Vitaminler ve Enzimler. Ankara Üniversitesi, Eczacılık Fakültesi Yayınları, Ders Kitabı Serisi, (s. 46). içinde Ankara Üniversitesi, Eczacılık Fakültesi Yayınları.

    • Combs Jr, G. F., & McClung, J. P. (2016). Chapter 13: Niasin. The Vitamins, Fundamental Aspects in Nutrition and Health Fifth Edition. içinde New York: Academic Press.

    • Baysal, A. (2011). Beslenme. Hatiboğlu Basım ve Yayım.

    • Kirkland, J. B., & Meyer-Ficca, M. L. (2018). Niacin. Advances in food and nutrition research, 83, 83-149.

    • Guyton, J. R., Blazing, M. A., Hagar, J., Kashyap, M. L., Knopp, R. H., McKenney, J. M., & Nash, S. D. (2000). Extended-release niacin vs gemfibrozil for the treatment of low levels of high-density lipoprotein cholesterol. Archives of internal medicine, 160(8), 1177-1184.

    • http://temelsaglik2.saglik.gov.tr/dosya/Yayinlar/VitaminlerMineraller (Mayıs 2011).

    • Head K.A. Peripheral neuropathy: pathogenic mechanisms and alternative therapies. Altern Med Rev. 2006; 11(4): 294–329.

    • Stracke H., Lindemann A., Federlin K. A Benfotiamine and Vitamin B Combination in treatment of diabetic polyneuropathy. Exp Clin Endocrinol Diabetes. 1996; 104(4): 311-6.

    • Combs, G. F. The Vitamins: Fundamental Aspects in Nutrition and Health. San Diego: Elsevier. 2008.

    • Healton E.B., Savage D.G., Brust J.C., Garrett T.J., Lindenbaum J. Neurologic aspects of cobalamin deficiency. Medicine. 1991; 70(4): 229-45.

    • Briddon A. Homocysteine in the context of cobalamin metabolism and deficiency states. Amino Acids. 2003; 24(1-2): 1-12.

    • Medina-Santillán R., Morales-Franco G., Espinoza-Raya J., Garanados-Soto V., Reyes-Garcia G., Treatment of Diabetic Neuropathic Pain with Gabapentin Alone or Combined with Vitamin B Complex Preliminary Result. Proc. West. Pharmacol. Soc. 2004; 47: 109-12.

    • Dusso AS, Brown AJ, Slatopolsky E. Vitamin D. Am J Physiol Renal Physiol 2005;289:8-28.

    • Eyles DW, Burne TH, McGrath JJ. Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease. Front Neuroendocrinol 2012;34:47-64.

    • Gumireddy K, Ikegaki N, Phillips PC, et al. Effect of 20-epi-1alpha,25-dihydroxyvitamin D3 on the proliferation of human neuroblastoma: role of cell cycle regulators and the Myc-Id2 pathway. Biochem Pharmacol 2003;65:1943-1955.

    • Walbert T, Jirikowski GF, Prüfer K. Distribution of 1,25-dihydroxyvitamin D3 receptor immunoreactivity in the limbic system of the rat. Horm Metab Res 2001;33:525-531.

    • Taniura H, Ito M, Sanada N, et al. Chronic vitamin D3 treatment protects against neurotoxicity by glutamate in association with upregulation of vitamin D receptor mRNA expression in cultured rat cortical neurons. J Neurosci Res 2006;83:1179-1189.

    • Veenstra TD, Prüfer K, Koenigsberger C, et al. 1,25-Dihydroxyvitamin D3 receptors in the central nervous system of the rat embryo. Brain Res 1998;804:193- 205.

    • Sanchez B, Relova JL, Gallego R, et al. 1,25-Dihydroxyvitamin D3 administration to 6 hydroxydopamine-lesioned rats increases glial cell line-derived neurotrophic factor and partially restores tyrosine hy-droxylase expression in substantia nigra and striatum. J Neurosci Res 2009;87:723-732.

    • Marini F, Bartoccini E, Cascianelli G, et al. Effect of 1alpha,25-dihydroxyvitamin D3 in embryonic hippocampal cells. Hippocampus 2010;20:696-705.

    • Evatt ML, Delong MR, Khazai N, et al. Prevalence of vitamin d insufficiency in patients with Parkinson disease and Alzheimer disease. Arch Neurol 2008;65:1348-1352.

    • Newmark HL, Newmark J. Vitamin D and Parkinson’s disease--a hypothesis. Mov Disord 2007;22:461-468.

    • Kayaalp S.O., Rasyonel Tedavi Yönünden Tıbbi Farmakoloji Cilt:3, 6.Baskı, 1993. Syf:3065-3070.

    • Ebesunun O.M., Obajobi E.O. Elevated plasma homocysteine in type 2 diabetes mellitus: a risk factor for cardiovascular diseases. Pan Afr Med J. 2012; 12: 48.

    • Ghiselli A, Serafini M, Natella F, Scaccini C. Total antioxidant capacity as a tool to assess redox status:critical view and experimental data.Free Radic Biol Med 2000; 29:1106-14.

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