Release Date: 2023-09-14

Triggering Role of Viruses and Bacteria in Type I Diabetes

Hatice Hale Gumus (Author)

Release Date: 2023-09-14

The triggering role of viruses and bacteria in type 1 diabetes (T1D) involves complex interactions between genetic susceptibility, environmental factors, and the immune system. Viruses, particularly enteroviruses such as Coxsackievirus B, have been implicated in triggering autoimmune responses that lead to the destruction of insulin-producing beta cells in the pancreas. These viruses can infect pancreatic [...]

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Work TypeBook Chapter
Published inCurrent Multidisciplinary Approach to Diabetes Mellitus Occurrence Mechanism
First Page141
Last Page150
DOIhttps://doi.org/10.69860/nobel.9786053359104.13
ISBN978-605-335-910-4 (PDF)
LanguageENG
Page Count10
Copyright HolderNobel Tıp Kitabevleri
Licensehttps://nobelpub.com/publish-with-us/copyright-and-licensing

The triggering role of viruses and bacteria in type 1 diabetes (T1D) involves complex interactions between genetic susceptibility, environmental factors, and the immune system. Viruses, particularly enteroviruses such as Coxsackievirus B, have been implicated in triggering autoimmune responses that lead to the destruction of insulin-producing beta cells in the pancreas. These viruses can infect pancreatic beta cells directly or trigger an inflammatory response that activates autoreactive T cells, which mistakenly attack and destroy beta cells. Additionally, viral infections may disrupt immune tolerance mechanisms, leading to the production of autoantibodies against pancreatic antigens, a hallmark of T1D.
Bacterial infections, although less extensively studied compared to viruses, may also play a role in T1D pathogenesis. Some studies suggest that infections with certain gut microbiota, such as specific strains of Bacteroides and Firmicutes, could influence immune responses and contribute to autoimmune reactions against beta cells. The mechanisms by which bacteria may trigger or exacerbate T1D are still under investigation but likely involve interactions with the gut mucosa and modulation of immune responses.
Understanding the role of viruses and bacteria in T1D is crucial for developing preventive strategies and potential treatments that target these infectious triggers or modulate immune responses to preserve beta cell function. Ongoing research aims to elucidate these complex interactions and their implications for the development and progression of type 1 diabetes.

Hatice Hale Gumus (Author)
Çukurova University
https://orcid.org/0000-0001-9071-9606

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