Release Date: 2023-09-14

Biochemical Microvascular Complications of Diabetes

Rahim Kocabas (Author)

Release Date: 2023-09-14

Diabetes mellitus is associated with a spectrum of biochemical microvascular complications that significantly impact various organs and tissues. Chronic hyperglycemia, the hallmark of diabetes, leads to vascular damage through several interconnected pathways, including increased formation of advanced glycation end-products (AGEs), activation of protein kinase C (PKC) isoforms, and oxidative stress. These processes contribute to endothelial [...]

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Work TypeBook Chapter
Published inCurrent Multidisciplinary Approach to Diabetes Mellitus Occurrence Mechanism
First Page105
Last Page113
DOIhttps://doi.org/10.69860/nobel.9786053359104.10
ISBN978-605-335-910-4 (PDF)
LanguageENG
Page Count9
Copyright HolderNobel Tıp Kitabevleri
Licensehttps://nobelpub.com/publish-with-us/copyright-and-licensing

Diabetes mellitus is associated with a spectrum of biochemical microvascular complications that significantly impact various organs and tissues. Chronic hyperglycemia, the hallmark of diabetes, leads to vascular damage through several interconnected pathways, including increased formation of advanced glycation end-products (AGEs), activation of protein kinase C (PKC) isoforms, and oxidative stress. These processes contribute to endothelial dysfunction, impaired vasodilation, and inflammation, which collectively promote microvascular complications such as diabetic nephropathy, retinopathy, and neuropathy. In diabetic nephropathy, elevated glucose levels cause glomerular hyperfiltration and renal hypertrophy, leading to progressive loss of kidney function and the development of end-stage renal disease. Diabetic retinopathy, characterized by microvascular damage in the retina, can lead to vision impairment or blindness due to retinal hemorrhages, exudates, and neovascularization. Diabetic neuropathy involves damage to peripheral nerves, resulting in sensory deficits, pain, and autonomic dysfunction. Effective management of biochemical microvascular complications in diabetes includes intensive glycemic control, blood pressure management, lipid-lowering therapies, and regular screening for early detection and intervention. Targeting these pathways can help mitigate the progression of microvascular complications and improve long-term outcomes for individuals with diabetes mellitus.

Rahim Kocabas (Author)
Assistant Professor, Karamanoglu Mehmetbey University
https://orcid.org/0000-0001-8006-284X

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