Release Date: 2024-05-31

Endorphins and Some Herbal Sources That Support Endorphins

Mine Kocyigit (Author)

Release Date: 2024-05-31

Endorphins are a type of chemical compound produced naturally in the body and are commonly known as "happiness hormones." Endorphins reduce stress, reduce pain, and promote overall well-being. Some herbal sources may support endorphin production and increase endorphin levels in the body. One of them is chocolate. Cacao can increase endorphin production due to compounds [...]

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    Work TypeBook Chapter
    Published inBrain Health and Medicinal Plants
    First Page69
    Last Page86
    DOIhttps://doi.org/10.69860/nobel.9786053359241.5
    Page Count18
    Copyright HolderNobel Tıp Kitabevleri
    Licensehttps://nobelpub.com/publish-with-us/copyright-and-licensing

    Endorphins are a type of chemical compound produced naturally in the body and are commonly known as "happiness hormones." Endorphins reduce stress, reduce pain, and promote overall well-being. Some herbal sources may support endorphin production and increase endorphin levels in the body. One of them is chocolate. Cacao can increase endorphin production due to compounds called flavonoids and phenylethylamine found in it. Additionally, capsaicin found in red peppers may also stimulate the release of endorphins. Turmeric is one of the herbal sources that support endorphin production. Thanks to its anti-inflammatory properties, ginger can reduce stress in the body and increase the release of endorphins. As a result, some herbal sources, such as chocolate, cayenne pepper, turmeric, and ginger, can support endorphin production and increase endorphin levels in the body.

    Mine Kocyigit (Author)
    Associate Professor, Istanbul Universty
    https://orcid.org/0000-0002-7831-0151
    3Mine Koçyiğit completed her doctorate in 2010 at Istanbul University, Faculty of Pharmacy, Department of Pharmaceutical Botany. In 2014, she was appointed as an assistant professor in this department. She has been working as an associate professor since 2018. Her areas of expertise are medicinal plants, honey plants, medicinal plant systematics and ethnobotanical studies.

    • Berry J. Endorphins: Effects and how to increase levels. Medical News Today. 2018 Feb;6.

    • Li Y, Lefever MR, Muthu D, Bidlack JM, Bilsky EJ, Polt R. Opioid glycopeptide analgesics derived from endogenous enkephalins and endorphins. Future medicinal chemistry. 2012 Feb;4(2):205-26.

    • Shenoy SS, Lui F. Biochemistry, endogenous opioids. InStatPearls [Internet] 2023 Jun 12. StatPearls Publishing.

    • Ali AH, Ahmed HS, Jawad AS, Mustafa MA. Endorphin: function and mechanism of action. Sci Arch. 2021;2(1):9-13.

    • Adeodu OO, Olorunmoteni OE, Oseni SB, Obuotor EM. Plasma and cerebrospinal fluid beta-endorphin levels show a strong association in children with cerebral malaria. Journal of Pediatric Neurosciences. 2018 Oct 1;13(4):416-22.

    • Olson KM, Lei W, Keresztes A, LaVigne J, Streicher JM. Focus: Drug Development: Novel Molecular Strategies and Targets for Opioid Drug Discovery for the Treatment of Chronic Pain. The Yale journal of biology and medicine. 2017 Mar;90(1):97.

    • Bali A, Singh N, Singh Jaggi A. Neuropeptides as therapeutic targets to combat stress-associated behavioral and neuroendocrinological effects. CNS & Neurological Disorders-Drug Targets (Formerly Current Drug Targets-CNS & Neurological Disorders). 2014 Mar 1;13(2):347-68.

    • Hess SR, Lahaye LA, Waligora AC, Sima AP, Jiranek WA, Golladay GJ. Safety and side-effect profile of intrathecal morphine in a diverse patient population undergoing total knee and hip arthroplasty. European Journal of Orthopaedic Surgery & Traumatology. 2019 Jan 8;29:125-9.

    • Gomtsian L, Bannister K, Eyde N, Robles D, Dickenson AH, Porreca F, Navratilova E. Morphine effects within the rodent anterior cingulate cortex and rostral ventromedial medulla reveal separable modulation of affective and sensory qualities of acute or chronic pain. Pain. 2018 Dec 1;159(12):2512-21.

    • Anghelescu DL, Guo A, Morgan KJ, Frett M, Prajapati H, Gold R, Federico SM. Pain outcomes after celiac plexus block in children and young adults with cancer. Journal of Adolescent and Young Adult Oncology. 2018 Dec 1;7(6):666-72.

    • Junior JB, de Mello Bastos JM, Samuels RI, Carey RJ, Carrera MP. Reversal of morphine conditioned behavior by an anti-dopaminergic post-trial drug treatment during re-consolidation. Behavioural Brain Research. 2019 Feb 1;359:771-82.

    • Pilozzi A, Carro C, Huang X. Roles of β-endorphin in stress, behavior, neuroinflammation, and brain energy metabolism. International journal of molecular sciences. 2020 Dec 30;22(1):338.

    • Soverchia L, Mosconi G, Ruggeri B, Ballarini P, Catone G, Degl'Innocenti S, Nabissi M, Polzonetti‐Magni AM. Proopiomelanocortin gene expression and β‐endorphin localization in the pituitary, testis, and epididymis of stallion. Molecular Reproduction and Development: Incorporating Gamete Research. 2006 Jan;73(1):1-8.

    • Coates S, Lazarus P. Hydrocodone, Oxycodone, and Morphine Metabolism and Drug–Drug Interactions. Journal of pharmacology and experimental therapeutics. 2023 Nov 1;387(2):150-69.

    • Simbolon BM. Opioid and the usage in chronic non cancer pain. Jurnal Prima Medika Sains. 2023 Dec 27;5(2):196-205.

    • De Rosa F, Giannatiempo B, Charlier B, Coglianese A, Mensitieri F, Gaudino G, Cozzolino A, Filippelli A, Piazza O, Dal Piaz F, Izzo V. Pharmacological treatments and therapeutic drug monitoring in patients with chronic pain. Pharmaceutics. 2023 Aug 5;15(8):2088.

    • Bolash RB, Mekhail N. Managing Complications of Intrathecal Medications Used for Pain. InNeuraxial Therapeutics: A Comprehensive Guide 2024 Jan 3 (pp. 681-692). Cham: Springer International Publishing.

    • Minervini G, Franco R, Crimi S, Di Blasio M, D’Amico C, Ronsivalle V, Cervino G, Bianchi A, Cicciù M. Pharmacological therapy in the management of temporomandibular disorders and orofacial pain: a systematic review and meta-analysis. BMC Oral Health. 2024 Jan 13;24(1):78.

    • Matsumoto M, Nagata M, Kuroki Y, Shimizu K. Screening of Asian Natural Materials to Promote β-Endorphin Synthesis. Natural product communications. 2023 Feb;18(2):1934578X231152964.

    • Apryani E, Ali U, Wang ZY, Wu HY, Mao XF, Ahmad KA, Li XY, Wang YX. The spinal microglial IL-10/β-endorphin pathway accounts for cinobufagin-induced mechanical antiallodynia in bone cancer pain following activation of α7-nicotinic acetylcholine receptors. Journal of neuroinflammation. 2020 Dec;17:1-8.

    • Wang ZY, Han QQ, Deng MY, Zhao MJ, Apryani E, Shoaib RM, Wei DQ, Wang YX. Lemairamin, isolated from the Zanthoxylum plants, alleviates pain hypersensitivity via spinal α7 nicotinic acetylcholine receptors. Biochemical and biophysical research communications. 2020 May 14;525(4):1087-94.

    • Ghosh A, Chandra R, Jain U, Chauhan N. Investigating beta-endorphins: ways to boost health, conventional and future detection methods. Process Biochemistry. 2024 Mar 16.

    • Parker G, Parker I, Brotchie H. Mood state effects of chocolate. Journal of affective disorders. 2006 Jun 1;92(2-3):149-59.

    • Chaudhari SA, Devare R, Dewang PS, Patil VB, Patil AM, Pawar SP. Chocolate formulation as drug delivery system. Indian journal of drugs. 2018;6(2):136-41.

    • Duan G, Wu Z, Duan Z, Yang G, Fang L, Chen F, Bao X, Li H. Effects of spicy stimulation and spicy-food consumption on human pain sensitivity: a healthy volunteer study. The Journal of Pain. 2020 Jul 1;21(7-8):848-57.

    • Lee JS, Kim SG, Jeong HJ, Kim JH, Yang YH, Jung WY. Difference of the naltrexone's effects in social drinkers by spicy food preference. Journal of Korean Medical Science. 2014 May;29(5):714.

    • Park JH, Kim SG, Kim JH, Lee JS, Jung WY, Kim HK. Spicy food preference and risk for alcohol dependence in Korean. Psychiatry investigation. 2017 Nov;14(6):825.

    • Su L, Tong H, Zhang J, Hao M, Fei C, Ji D, Gu W, Bian Z, Mao C, Lu T. Revealing the mechanism of raw and vinegar-processed Curcuma aromatica Salisb.[Zingiberaceae] regulates primary dysmenorrhea in rats via integrated metabolomics. Frontiers in Pharmacology. 2022 Sep 13;13:926291.

    • Revathi S, Malathy NS. Antibacterial activity of rhizome of Curcuma aromatica and partial purification of active compounds. Indian journal of pharmaceutical sciences. 2013 Nov;75(6):732.

    • Fei C, Ji D, Tong H, Li Y, Su L, Qin Y, Bian Z, Zhang W, Mao C, Li L, Lu T. Therapeutic mechanism of Curcuma aromatica Salisb. rhizome against coronary heart disease based on integrated network pharmacology, pharmacological evaluation and lipidomics. Frontiers in Pharmacology. 2022 Aug 9;13:950749.

    • Zhao G, Shi Y, Gong C, Liu T, Nan W, Ma L, Wu Z, Da C, Zhou K, Zhang H. Curcumin exerts antinociceptive effects in cancer-induced bone pain via an endogenous opioid mechanism. Frontiers in Neuroscience. 2021 Sep 3;15:696861.

    • Liang X, Wang Y, Hu X, Wang S. The protective effects of water extracts of compound turmeric recipe on acute alcoholism: an experimental research using a mouse model, Evid. -Based Complement. Altern. Med. 2021 (2021) 1–13.

    • Pratiwi SR. The Effect of Valerian Root Extract on Reducing Dysmenorrhea Pain Levels and Endorphin Hormone Levels in Women of Childbearing Age. Archives of The Medicine and Case Reports. 2023 Aug 23;4(3):428-31.

    • Kim YJ, Kim HJ, Ahn YH. Effects of valerian root extract on pain intensity in patients with chronic low back pain: A randomized controlled trial. J Altern Complement Med. 2018; 24(6): 593-9.

    • Chen XY, Li Y, Zhao F. The analgesic effects of valerian root extract in patients with fibromyalgia: A double-blind, randomized, placebo-controlled study. Pain Med. 2017; 18(12): 2481-8.

    • García-Leiva JM, Hidalgo J, Romero-Moreno R. Valerian root extract in the treatment of post-operative pain in adults: A randomized controlled trial. J Pain Res. 2016; 9: 753-9.

    • Zhang H, Wang D, Li Y. The analgesic effects of valerian root extract in patients with acute appendicitis: A randomized controlled trial. J Surg Res. 2004; 117(2): e107-e112.

    • Zahid H, Rizwani GH, Ishaqe S. Phytopharmacological Review on Vitex agnus-castus: A Potential Medicinal Plant. Chin.Herb. Med. 2016; 8: 24–29.

    • Webster DE, Lu J, Chen SN, Farnsworth NR, Wang ZJ. Activation of the μ-opiate receptor by Vitex agnus-castus methanol extracts: implication for its use in PMS. Journal of ethnopharmacology. 2006 Jun 30;106(2):216-21.

    • Piazzini V, Monteforte E, Luceri C, Bigagli E, Bilia AR, Bergonzi MC. Nanoemulsion for improving solubility and permeability of Vitex agnus-castus extract: formulation and in vitro evaluation using PAMPA and Caco-2 approaches. Drug delivery. 2017 Jan 1;24(1):380-90.

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