Release Date: 2024-02-12
Gene Therapy and Cardiovascular Diseases
Osman Ozdabakoglu (Author), Muhammed Erdem Akpolat (Author)
Release Date: 2024-02-12
Current methods are inadequate in the treatment of cardiovascular diseases, which reduce the quality of life and even threaten the lives of millions of people around the world. New and effective methods are constantly being sought for this. Correcting genetic changes or adding missing genes, especially in heart muscle cells, stands out as a potential [...]
Media Type
Buy from
Price may vary by retailers
| Work Type | Book Chapter |
|---|---|
| Published in | Gene Therapy |
| First Page | 119 |
| Last Page | 127 |
| DOI | https://doi.org/10.69860/nobel.9786053358824.8 |
| Page Count | 9 |
| Copyright Holder | Nobel Tıp Kitabevleri |
| License | https://nobelpub.com/publish-with-us/copyright-and-licensing |
Osman Ozdabakoglu (Author)
MD, Specialist Doctor, Private Acıbadem Bursa Hospital
https://orcid.org/0000-0002-2837-3015
3Osman Özdabakoğlu, currently works as a specialist cardiologist at Acıbadem Hospital. I graduated from Kocaeli University Faculty of Medicine with the title of Medical Doctor in 2005. in 2010, I became a cardiologist. I have many research and projects on heart diseases. The areas I am most interested in are heart failure , coronary heart diseases, invazive treatment.
Muhammed Erdem Akpolat (Author)
MD, Doctor, Istanbul Prof. Dr. Cemil Taşcıoğlu Cıty Hospıtal
https://orcid.org/0009-0002-2525-2370
3Muhammed Erdem Akpolat is currently He works as a medical doctor in Prof. Dr. Cemil Taşçıoğlu State Hospital of the emergency department. He graduated from Biruni University Faculty of Medicine with the title of medical doctor in 2023. He took part in scientific research during his years at medical school. He was still having book chapters published in the scientific medical field on subjects such as the effects of radiation on living systems, electroacupuncture, acupuncture medical applications. The areas he is most interested in are new therapy methods in medical diseases.
Cannatà A, Ali H, Sinagra G, Giacca M. Gene Therapy for the Heart Lessons Learned and Future Perspectives. Circ Res. 2020 May 8;126(10):1394-1414.
Ferrara N, Alitalo K. Clinical applications of angiogenic growth factors and their inhibitors. Nat Med1999;5:1359–1364.
Yla-Herttuala S, Rissanen TT, Vajanto I, Hartikainen J. Vascular endothelial growth factors: biology and current status of clinical applications in cardiovascular medicine. J Am Coll Cardiol2007;49:1015–1026.
Rasmussen, H.S., Rasmussen, C.S., Macko, J.: VEGF gene therapy for coronary artery disease and peripheral vascular disease. Cardiovasc Radiat Med 2002: 3(2); 114-117.
Rosengart TK, Lee LY, Patel SR, et al. Angiogenesis gene therapy: phase I assessment of direct intramyocardial administration of an adenovirus vector expressing VEGF121 cDNA to individuals with clinically significant severe coronary artery disease. Circulation1999;100:468–474.
Hassinen I, Hartikainen J, Hedman A. et al. Adenoviral intramyocardial VEGF-D transfer increases myocardial perfusion in refractory angina patients. Circulation2015; 132:A11987.
Kaminsky SM., Quach L., Chen S., et al. Safety of direct administration of ADVEGFALL6A+, an adenovirus vector expressing a CDNA/genomic hybrid of human vascular endothelial growth factors, to the ischemic myocardium of rats. Mol Ther2013;21:S143.
Henry TD., Grines CL., Watkins MW., et al. Effects of Ad5FGF-4 in patients with angina. An analysis of pooled data from the AGENT-3 and AGENT-4 Trials. J Am Coll Cardiol2007;50:1038–1046.
Yang ZJ., Zhang YR., Chen B., et. al. Phase i clinical trial on intracoronary administration of Ad-hHGF treating severe coronary artery disease. Mol Biol Rep2009;36:1323–1329.
Criqui MH, Aboyans V. Epidemiology of Peripheral Artery Disease. Circ Res2015;116:1509–1526.
Tendera M, Aboyans V, Bartelink M-L, et al. ESC Guidelines on the diagnosis and treatment of peripheral artery diseases. Eur Heart J2011;32: 2851–2906.
Yla-Herttuala S, Rissanen TT, Vajanto I, Hartikainen J. Vascular endothelial growth factors: biology and current status of clinical applications in cardiovascular medicine. J Am Coll Cardiol2007;49:1015–1026.
Muona K, Makinen K, Hedman M, Manninen H, Yla-Herttuala S. 10-year safety follow-up in patients with local VEGF gene transfer to ischemic lower limb. Gene Ther2012;19:392–395.
Deev RV., Bozo IY., Mzhavanadze ND., et al. pCMV-vegf165 intramuscular gene transfer is an effective method of treatment for patients with chronic lower limb ischemia. J Cardiovasc Pharmacol Ther2015;20:473–482.
Hammer A, Steiner S. Gene therapy for therapeutic angiogenesis in peripheral arterial disease - a systematic review and meta-analysis of randomized, controlled trials. Vasa2013;42:331–339.
17. Makinen K., Manninen H., Hedman M.,et al. Increased vascularity detected by digital subtraction angiography after VEGF gene transfer to human lower limb artery: a randomized, placebo-controlled, double-blinded phase II study. Mol Ther2002;6:127– 133.
Kusumanto YH., Weel VV., Mulder NH., et al. Treatment with intramuscular vascular endothelial growth factor gene compared with placebo for patients with diabetes mellitus and critical limb ischemia: a double-blind randomized trial. Hum Gene Ther2006;17:683–691.
Rajagopalan S., Mohler IIIER., Lederman RJ., et al. Regional angiogenesis with vascular endothelial growth factor in peripheral arterial disease: a phase II randomized, double-blind, controlled study of adenoviral delivery of vascular endothelial growth factor 121 in patients with disabling intermittent cl. Circulation2003;108:1933–1938.
| onix_3.0::thoth | Thoth ONIX 3.0 |
|---|---|
| onix_3.0::project_muse | Project MUSE ONIX 3.0 |
| onix_3.0::oapen | OAPEN ONIX 3.0 |
| onix_3.0::jstor | JSTOR ONIX 3.0 |
| onix_3.0::google_books | Google Books ONIX 3.0 |
| onix_3.0::overdrive | OverDrive ONIX 3.0 |
| onix_2.1::ebsco_host | EBSCO Host ONIX 2.1 |
| csv::thoth | Thoth CSV |
| json::thoth | Thoth JSON |
| kbart::oclc | OCLC KBART |
| bibtex::thoth | Thoth BibTeX |
| doideposit::crossref | CrossRef DOI deposit |
| onix_2.1::proquest_ebrary | ProQuest Ebrary ONIX 2.1 |
| marc21record::thoth | Thoth MARC 21 Record |
| marc21markup::thoth | Thoth MARC 21 Markup |
| marc21xml::thoth | Thoth MARC 21 XML |
