Release Date: 2023-09-14

Apoptosis Induced by Diabetes

Dervis Dasdelen (Author)

Release Date: 2023-09-14

Apoptosis induced by diabetes refers to programmed cell death that occurs in various tissues and organs as a consequence of chronic hyperglycemia and associated metabolic disturbances. In diabetes mellitus, prolonged exposure to elevated glucose levels triggers multiple pathways leading to cellular stress, oxidative damage, and ultimately, apoptosis. This phenomenon is particularly notable in pancreatic beta [...]

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Work TypeBook Chapter
Published inCurrent Multidisciplinary Approach to Diabetes Mellitus Occurrence Mechanism
First Page133
Last Page139
DOIhttps://doi.org/10.69860/nobel.9786053359104.12
ISBN978-605-335-910-4 (PDF)
LanguageENG
Page Count7
Copyright HolderNobel Tıp Kitabevleri
Licensehttps://nobelpub.com/publish-with-us/copyright-and-licensing

Apoptosis induced by diabetes refers to programmed cell death that occurs in various tissues and organs as a consequence of chronic hyperglycemia and associated metabolic disturbances. In diabetes mellitus, prolonged exposure to elevated glucose levels triggers multiple pathways leading to cellular stress, oxidative damage, and ultimately, apoptosis. This phenomenon is particularly notable in pancreatic beta cells, where apoptosis contributes to the progressive decline in insulin secretion and the development of type 1 and type 2 diabetes. In addition to pancreatic beta cells, apoptosis is observed in endothelial cells of blood vessels, renal tubular cells, neurons, and cardiomyocytes, contributing to diabetic complications such as nephropathy, neuropathy, retinopathy, and cardiovascular disease. Mechanisms underlying apoptosis in diabetes involve mitochondrial dysfunction, activation of pro-apoptotic signaling pathways (such as caspase activation and Bcl-2 family proteins), and increased production of reactive oxygen species (ROS). Therapeutic strategies targeting apoptosis aim to mitigate cellular damage and preserve tissue function through interventions that improve glycemic control, reduce oxidative stress, and enhance cellular survival mechanisms.

Dervis Dasdelen (Author)
Assistant Professor, Karamanoglu Mehmetbey University
https://orcid.org/0000-0002-2378-8780

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