Hypoglycemia in diabetes mellitus patients presenting to the emergency department (ED) requires rapid assessment and intervention to prevent complications and ensure patient safety. Initial evaluation includes checking vital signs, mental status, and blood glucose levels to confirm hypoglycemia (typically defined as blood glucose <70 mg/dL). Prompt treatment involves administering oral or intravenous glucose to raise blood sugar levels quickly. Glucagon injection may be necessary for patients who are unable to take oral glucose due to altered consciousness or intravenous access issues. Close monitoring post-treatment is crucial to prevent rebound hypoglycemia and ensure stabilization. Identifying and addressing the underlying cause of hypoglycemia, such as excessive insulin or oral hypoglycemic agents, missed meals, or increased physical activity, is essential to prevent recurrence. Education on recognizing symptoms, self-management strategies, and preventing future episodes is integral before discharge, emphasizing the importance of regular blood glucose monitoring and adjusting medication doses as needed. Collaborative efforts between healthcare providers, diabetes educators, and patients optimize management and reduce the risk of hypoglycemia-related ED visits.