This chapter presents botanical and chemical properties, and therapeutic potential in neurological diseases of medicinal plants currently utilized in Parkinson’s disease. Parkinson’s disease is the second most common neurological brain disease that accompanied by movement disorders. Currently used modern medicines such as levodopa have serious side effects and therefore safe, and effective medicines from natural sources with minimized side effects are necessary for the management and/or treatment of Parkinson’s disease. Natural sources especially plant-based materials are rich in antioxidant compounds and therefore, they can be examined for the discovery of new drugs that can be used in the treatment of Parkinson’s disease. Within this chapter 18 common medicinal plants including Centella asiatica, Panax ginseng, Carthamus tinctorius, Mucuna pruriens, Gingko biloba, Hypericum perforatum, Ocimum santam, Hibiscus asper, Sida cordifolia, Tinospora cordifolia, Peganum harmala, Paeonia lactiflora, Bacopa monnieri, Polygola tenuifolia, Polygonum cuspidatum, Withania somnifera, Camellia sinensis, and Curcuma longa were reviewed. All medicinal plants reported in this chapter were found to have a common mode of action, namely stabilizing redox and stimulating mitochondrial function. It was determined that the chemical compounds of the plant species mentioned in this chapter have significant anti-Parkinson performance and therefore can be examined in clinical Parkinson’s studies which targeted for the discovery of natural-based effective and safe anti-Parkinson drugs.