Sarcoidosis is a multifaceted disease that manifests in diverse clinical presentations, making it a diagnostic challenge and highlighting its variable impact on patients’ health. This chapter explores the broad spectrum of clinical manifestations observed in sarcoidosis, ranging from asymptomatic disease to severe organ dysfunction. Commonly affected organs include the lungs, skin, eyes, lymph nodes, and heart, each presenting unique symptoms and complications. By detailing the clinical features and patterns of organ involvement, we aim to equip healthcare professionals and patients alike with a comprehensive understanding of the heterogeneous nature of sarcoidosis. This knowledge is essential for early recognition, accurate diagnosis, and tailored management strategies to optimize patient outcomes and quality of life.