Release Date: 2024-01-16

Chemical Carcinogens in Food

Sule Bolukbas Ozdemir (Author), Havva Nur Peltek Kendirci (Author)

Release Date: 2024-01-16

The word carcinogenic is defined as the capacity of a compound to unleash the cancer development process in humans and animals by acting on one of the different organs or tissues under appropriate conditions. However, with the demonstration of different mechanisms involved in carcinogenesis, it is accepted that this definition is not sufficient. From an [...]

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    Work TypeBook Chapter
    Published inFood Safety
    First Page333
    Last Page351
    DOIhttps://doi.org/10.69860/nobel.9786053358787.23
    Page Count19
    Copyright HolderNobel Tıp Kitabevleri
    Licensehttps://nobelpub.com/publish-with-us/copyright-and-licensing

    The word carcinogenic is defined as the capacity of a compound to unleash the cancer development process in humans and animals by acting on one of the different organs or tissues under appropriate conditions. However, with the demonstration of different mechanisms involved in carcinogenesis, it is accepted that this definition is not sufficient. From an experimental perspective, a compound is considered carcinogenic when its administration to laboratory animals causes a statistically significant increase in the incidence of one or more types of histological neoplasia compared to animals in a control group not exposed to the substance.
    The use of chemical compounds benefits society in different ways. For example, pesticides enable food to be produced in sufficient quantities to meet the needs of millions of people. However, from time to time these benefits can turn into bad results with some disadvantages, especially the toxic side effects of the chemical compounds used. Exposure to these compounds can have effects ranging from sudden death to a gradual process of chemical carcinogenesis. There are three stages in chemical carcinogenesis. These; They are classified as initiation, promotion and progression. Each of these stages is characterized by morphological and biochemical changes and consists of genetic and/or epigenetic changes. Genetic modifications include: mutations in genes that control cell proliferation, cell death, and DNA repair; namely, mutations in proto-oncogenes and tumor suppressor genes. Epigenetic factors, which are also thought to have a non-genetic character, may also contribute to carcinogenesis through epigenetic mechanisms that silence gene expression.

    Sule Bolukbas Ozdemir (Author)
    Hitit University
    https://orcid.org/0000-0001-7509-3326
    3Specialist dietitian Şule Bölükbaş Özdemir completed her education at Ankara University, Department of Nutrition and Dietetics in 2014. She completed her specialty training at Kırıkkale University Faculty of Medicine, Department of Child Health and Diseases, Department of Nutrition and Metabolism in 2018. In 2022, he started his PhD education at Ankara University, Faculty of Pharmacy, Department of Biochemistry and continues. She has been working at the Pediatric Diet Clinic at Hitit University Erol Olçok Training and Research Hospital since 2017. He has 3 published research articles, 5 book chapters, 2 oral presentations, 1 poster and ongoing studies on different subjects.

    Havva Nur Peltek Kendirci (Author)
    Professor, Hitit University
    https://orcid.org/0000-0001-7398-765X
    3Havva Nur Peltek Kendirci, Prof. Dr. Hitit University Faculty of Medicine, Department of Child Health and Diseases. He graduated from Ege University Faculty of Medicine in 1999. Between 1999 and 2004, she worked as an assistant doctor in the Department of Child Health and Diseases at SSK Ankara Pediatrics Training Hospital. She worked as a Child Health and Diseases Specialist at Keçiören Training and Research Hospital between 2005 and 2009. Between 2009 and 2012, he worked as a subspecialty assistant at Dr Sami Ulus Gynecology, Child Health and Diseases Training and Research Hospital - Pediatric Endocrinology Clinic. He worked at Edirne State Hospital between 2012 and 2015, and has been working at Hitit University Faculty of Medicine, Department of Child Health and Diseases since 2015.

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