Release Date: 2024-06-10

A Promising Bioactive Phytochemical; Rosmarinic Acid, Targets Nervous System Disorders

Oguz Cakir (Author), Mustafa Abdullah Yilmaz (Author)

Release Date: 2024-06-10

Rosmarinic acid (RA), a phenolic molecule found in culinary herbs, has shown potential therapeutic benefits for various neurodegenerative disorders due to its antiapoptotic, antioxidant, and anti-inflammatory properties. RA can reduce oxidative stress, prevent cytotoxicity, and protect against neurotoxicity caused by various substances. It also mitigates the effects of metal ions and prevents iron-induced neurotoxicity in [...]

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    Work TypeBook Chapter
    Published inNeurological Diseases and Treatments in Terms of Biochemistry
    First Page125
    Last Page140
    DOIhttps://doi.org/10.69860/nobel.9786053359357.8
    Page Count16
    Copyright HolderNobel Tıp Kitabevleri
    Licensehttps://nobelpub.com/publish-with-us/copyright-and-licensing

    Rosmarinic acid (RA), a phenolic molecule found in culinary herbs, has shown potential therapeutic benefits for various neurodegenerative disorders due to its antiapoptotic, antioxidant, and anti-inflammatory properties. RA can reduce oxidative stress, prevent cytotoxicity, and protect against neurotoxicity caused by various substances. It also mitigates the effects of metal ions and prevents iron-induced neurotoxicity in neuroblastoma cells. RA’s potential to improve central nervous system disorders is growing worldwide. It has been shown to suppress GABA transaminase activity and reduce seizures, and may be used in combination with anti-epileptic medications. RA can also reduce lipid peroxidation and prevent neurodegeneration in the hippocampus. However, its efficacy may be limited by endogenous barriers to targeted brain delivery, bioavailability, bio-accessibility, limited membrane permeability, and poor water-and lipid-solubility. Further research is needed to understand the precise biochemical pathways and key actors contributing to RA’s therapeutic benefits and make RA a suitable phytochemical dietary treatment for neurological disorders.

    Oguz Cakir (Author)
    Associate Professor, Dicle University
    https://orcid.org/0000-0002-8006-2054
    3B.S. 2008, Chemistry, Kahramanmaraş Sütçü İmam University M.Sc. 2011, Chemistry, Inonu University Ph.D. 2017, Chemistry, Dicle University ACADEMIC WORK and EMPLOYMENT Dicle University, Faculty of Health Sciences, Department of Nutrition and Dietetics, Associate Professor, 2023-Present. RESEARCH Research Areas: analytical method validation, phytochemical analyses by HPLC, LC-MS/MS, and high-resolution mass spectrometry, and bioactivity investigation of natural products such as antioxidant, enzyme inhibitory, and cytotoxicity.

    Mustafa Abdullah Yilmaz (Author)
    Associate Professor, Dicle University
    https://orcid.org/0000-0002-4090-7227
    3Born: December 30, 1979 B.S. 2004, Chemistry, Middle East Technical University M.Sc. 2009, Chemistry, Harran University Ph.D. 2015, Chemistry, Dicle University ACADEMIC WORK and EMPLOYMENT Dicle University, Faculty of Pharmacy Associate Professor, Department of Analytical Chemistry, 2021-Present. Assistant Professor, Department of Pharmaceutical Chemistry, 2016-2021. Head of Mass Spectrometry and Chromatography Unit Dicle University Science and Technology Research and Application Center (DUBTAM), 2012-2021. RESEARCH Research Areas: analytical method validation, phytochemical analyses by HPLC, LC-MS/MS, and high-resolution mass spectrometry, and bioactivity investigation of natural products such as antioxidant, enzyme inhibitory, and cytotoxicity. WOS h index:23 120 scientific papers

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