Antidiabetic drug interactions pose significant challenges in the management of diabetes mellitus. These interactions can occur between different classes of antidiabetic medications or between antidiabetic drugs and other medications used to treat comorbid conditions. They may affect drug efficacy or safety by altering drug metabolism, absorption, or excretion. Common interactions include sulfonylureas, which can potentiate hypoglycemia when combined with other drugs that affect glucose levels. Similarly, medications such as corticosteroids or certain antibiotics can impair glucose control in diabetic patients. Clinicians must carefully monitor and adjust medication regimens to minimize these interactions and optimize therapeutic outcomes for patients with diabetes.