Metabolomics in Alzheimer’s Disease

The accumulation of amyloid-beta (Aβ) and phosphorylated tau (p-tau) proteins are known contributors to Alzheimer’s Disease (AD) pathogenesis, yet pharmacological interventions targeting these proteins have not been effective, indicating the involvement of additional molecular factors. These factors include lipid dyshomeostasis, altered energy and glucose metabolism, disturbed mitochondrial activity, oxidative stress, dysregulated cellular trafficking, and changes [...]