Alzheimer’s Disease: Link to Biomolecular Mechanisms and Clinical Pathologies

The pathogenesis of Alzheimer’s disease involves several interconnected mechanisms that contribute to neuronal dysfunction and brain atrophy. One of the central features of AD is the accumulation of amyloid-beta (Aβ) plaques in the brain. The resultant Aβ peptides aggregate to form insoluble plaques that disrupt cell-to-cell communication and activate immune responses, leading to inflammation and [...]