Relationship Between Dyslipidemia and Alzheimer’s Disease

Dyslipidemia may affect AD development through mechanisms involving ApoE4 levels, neuroinflammation, oxidative stress, cholesterol interactions with amyloid plaques and synaptic function, and vascular components. Increased cholesterol levels alter the blood-brain barrier’s permeability, potentially contributing to AD. ApoE, particularly its ε4 allele, is a significant genetic risk factor for AD. ApoE is involved in lipid transport [...]