Release Date: 2023-09-14

Evaluation of Diabetes and Biochemical Markers

Volkan Ecesoy (Author), Hasan Arici (Author)

Release Date: 2023-09-14

The evaluation of diabetes through biochemical markers involves a comprehensive approach to assess metabolic disturbances and monitor disease progression. Key biochemical markers include blood glucose levels, glycosylated hemoglobin (HbA1c), and insulin sensitivity indices such as the homeostatic model assessment of insulin resistance (HOMA-IR). Blood glucose levels are fundamental for diagnosing and managing diabetes, with fasting [...]

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Work TypeBook Chapter
Published inCurrent Multidisciplinary Approach to Diabetes Mellitus Occurrence Mechanism
First Page37
Last Page43
DOIhttps://doi.org/10.69860/nobel.9786053359104.4
ISBN978-605-335-910-4 (PDF)
LanguageENG
Page Count7
Copyright HolderNobel Tıp Kitabevleri
Licensehttps://nobelpub.com/publish-with-us/copyright-and-licensing

The evaluation of diabetes through biochemical markers involves a comprehensive approach to assess metabolic disturbances and monitor disease progression. Key biochemical markers include blood glucose levels, glycosylated hemoglobin (HbA1c), and insulin sensitivity indices such as the homeostatic model assessment of insulin resistance (HOMA-IR). Blood glucose levels are fundamental for diagnosing and managing diabetes, with fasting plasma glucose and oral glucose tolerance tests providing insights into glycemic control. HbA1c, reflecting average blood glucose levels over the preceding 2-3 months, is pivotal in assessing long-term glycemic control and guiding therapeutic interventions. Additionally, markers of insulin resistance, such as elevated HOMA-IR, indicate impaired insulin sensitivity and are crucial for understanding the underlying metabolic dysregulation in type 2 diabetes mellitus (T2DM). Furthermore, lipid profile assessments, including triglycerides and HDL cholesterol, offer insights into associated cardiovascular risk factors prevalent in diabetic patients. Overall, the use of biochemical markers in diabetes evaluation enables clinicians to tailor treatment strategies, monitor disease progression, and mitigate complications, thereby enhancing patient outcomes and quality of life.

Volkan Ecesoy (Author)
Assistant Professor, Karamanoglu Mehmetbey University
https://orcid.org/0000-0002-0760-4574

Hasan Arici (Author)
Assistant Professor, Karamanoglu Mehmetbey University
https://orcid.org/0000-0002-7929-7681

  • Diabetes TFOT. Diagnosis And Treatment Of Diabetes. 9 ed: Armony-Nüans; 2019.

  • Association AD. 2. Classifi cation and Diagnosis of Diabetes: Standards of Medical Care in Diabetes—2021. Diabetes care. 2020;44 (Supplement_1):S15-S33.

  • Ogurtsova K, Guariguata L, Barengo NC, Ruiz PL, Sacre JW, Karuranga S, et al. IDF diabetes Atlas: Global estimates of undiagnosed diabetes in adults for 2021. Diabetes research and clinical practice. 2022;183:109118.

  • Harding JL, Pavkov ME, Magliano DJ, Shaw JE, Gregg EW. Global trends in diabetes complications: a review of current evidence. Diabetologia. 2019;62(1):3-16.

  • Sacks DB, Arnold M, Bakris GL, Bruns DE, Horvath AR, Kirkman MS, et al. Position statement executive summary: guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus. Diabetes care. 2011;34(6):1419-23.

  • Association TEAM. TEMD Diabetes Mellitus and Its Complications Diagnosis, Treatment, and Follow-up Guide. 15 ed. Ankara: BAYT Publication; 2022.

  • Christy AL, Manjrekar PA, Babu RP, Hegde A, Rukmini MS. Infl uence of iron defi ciency anemia on hemoglobinA1c levels in diabetic individuals with controlled plasma glucose levels. Iranian biomedical journal. 2014;18(2):88-93.

  • Solomon A, Hussein M, Negash M, Ahmed A, Bekele F, Kahase D. Effect of iron defi ciency anemia on HbA1c in diabetic patients at Tikur Anbessa specialized teaching hospital, Addis Ababa Ethiopia. BMC hematology. 2019;19:2.

  • Maddaloni E, Bolli GB, Frier BM, Little RR, Leslie RD, Pozzilli P, et al. C-peptide determination in the diagnosis of type of diabetes and its management: A clinical perspective. Diabetes, obesity & metabolism. 2022;24(10):1912-26.

  • Achenbach P, Warncke K, Reiter J, Naserke HE, Williams AJ, Bingley PJ, et al. Stratifi cation of type 1 diabetes risk on the basis of islet autoantibody characteristics. Diabetes. 2004;53(2):384-92.

  • Bingley PJ, Williams AJ. Islet autoantibody testing: an end to the trials and tribulations? Diabetes. 2013;62(12):4009-11.

  • de Brito Rocha S, Baldo DC, Andrade LEC. Clinical and pathophysiologic relevance of autoantibodies in rheumatoid arthritis. Advances in rheumatology (London, England). 2019;59(1):2.

  • Kim HJ, Kim SS, Song SH. Glomerular fi ltration rate as a kidney outcome of diabetic kidney disease: a focus on new antidiabetic drugs. The Korean journal of internal medicine. 2022;37(3):502-19.

  • Shahbaz H, Gupta M. Creatinine Clearance. StatPearls. Treasure Island (FL): StatPearls PublishingCopyright © 2023, StatPearls Publishing LLC.; 2023.

  • Calabrese V, Labbozzetta V, Lipari A, Labbozzetta V, Gembillo G, Cernaro V, et al. Comparison between Creatinine Clearance and eGFRcyst-crea: a real-life experience. Giornale italiano di nefrologia : organo uffi ciale della Societa italiana di nefrologia. 2022;39(4).

  • Prasad RM, Tikaria R. Microalbuminuria. StatPearls. Treasure Island (FL): StatPearls Publishing Copyright © 2022, StatPearls Publishing LLC.; 2022.

  • Jarraya F, Lakhdar R, Kammoun K, Mahfoudh H, Drissa H, Kammoun S, et al. Microalbuminuria: a useful marker of cardiovascular disease. Iranian journal of kidney diseases. 2013;7(3):178-86.

  • Varghese RT, Jialal I. Diabetic Nephropathy. StatPearls. Treasure Island (FL): StatPearls Publishing Copyright © 2022, StatPearls Publishing LLC.; 2022.

  • Ghimire P, Dhamoon AS. Ketoacidosis. StatPearls. Treasure Island (FL): StatPearls Publishing Copyright © 2022, StatPearls Publishing LLC.; 2022.

  • Hassan EM, Mushtaq H, Mahmoud EE, Chhibber S, Saleem S, Issa A, et al. Overlap of diabetic ketoacidosis and hyperosmolar hyperglycemic state. World journal of clinical cases. 2022;10(32):11702-11.

  • Kumar S, Mondal H, Lata M, Behera JK, Priyadarshini B. Correlation of serum uric acid with lipid profi le in patients with type 2 diabetes mellitus with normal creatinine level: Report from a tertiary care hospital in India. Journal of family medicine and primary care. 2022;11(6):3066-70.

  • Noroozi Karimabad M, Khalili P, Ayoobi F, Esmaeili-Nadimi A, La Vecchia C, Jamali Z. Serum liver enzymes and diabetes from the Rafsanjan cohort study. BMC endocrine disorders. 2022;22(1):127.

  • Tanase DM, Gosav EM, Costea CF, Ciocoiu M, Lacatusu CM, Maranduca MA, et al. The Intricate Relationship between Type 2 Diabetes Mellitus (T2DM), Insulin Resistance (IR), and Nonalcoholic Fatty Liver Disease (NAFLD). Journal of Diabetes Research. 2020;2020:3920196.

  • Hillier TA, Pedula KL, Vesco KK, Schmidt MM, Mullen JA, LeBlanc ES, et al. Excess gestational weight gain: modifying fetal macrosomia risk associated with maternal glucose. Obstetrics and gynecology. 2008;112(5):1007-14.

  • Maratou E, Hadjidakis DJ, Kollias A, Tsegka K, Peppa M, Alevizaki M, et al. Studies of insulin resistance in patients with clinical and subclinical hypothyroidism. European journal of endocrinology. 2009;160(5):785-90.

  • Hirst JA, Farmer AJ, Ali R, Roberts NW, Stevens RJ. Quantifying the effect of metformin treatment and dose on glycemic control. Diabetes care. 2012;35(2):446-54.

  • Allen LH. How common is vitamin B-12 defi ciency? The American journal of clinical nutrition. 2009;89(2):693s-6s.

  • Quadros EV. Advances in the understanding of cobalamin assimilation and metabolism. British journal of haematology. 2010;148(2):195-204.

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