Release Date: 2024-06-12

Some Functions of Serotonin in the Central Nervous System

Release Date: 2024-06-12

Serotonin is a neurotransmitter that plays a vital role in the central nervous system and peripheral nervous system, affecting various physiological and behavioral activities. It is synthesized from tryptophan, an essential amino acid, and is involved in functions such as mood regulation, cognition, memory, anxiety, sleep, appetite, and gastrointestinal homeostasis. Serotonin receptors are spread throughout [...]

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    Work TypeBook Chapter
    Published inBrain Biochemistry and Its Disease
    First Page39
    Last Page64
    DOIhttps://doi.org/10.69860/nobel.9786053359371.3
    Page Count26
    Copyright HolderNobel Tıp Kitabevleri
    Licensehttps://nobelpub.com/publish-with-us/copyright-and-licensing
    Serotonin is a neurotransmitter that plays a vital role in the central nervous system and peripheral nervous system, affecting various physiological and behavioral activities. It is synthesized from tryptophan, an essential amino acid, and is involved in functions such as mood regulation, cognition, memory, anxiety, sleep, appetite, and gastrointestinal homeostasis. Serotonin receptors are spread throughout the body, with different subtypes mediating diverse effects through various signaling pathways. Changes in serotonin levels have been linked to neuropsychiatric disorders such as anxiety, depression, and schizophrenia. Research on serotonin has shown its involvement in neural plasticity, cognition, happiness, and various neurological disorders. Understanding the functions and mechanisms of serotonin is crucial for the development of treatments for related conditions.

    Necmettin Aktepe (Author)
    Associate Professor, Mardin Artuklu University
    https://orcid.org/0000-0003-2192-9049
    3Assoc. Dr. Necmettin Aktepe. I completed my undergraduate education at Konya Selçuk University, Faculty of Science, Department of Biology. I completed my master’s degree in chemistry at Harran University and my doctorate in clinical biochemistry at Ankara University Health Sciences Institute. I received my associate professorship in clinical biochemistry in 2023. I have been working as a faculty member at Mardin Artuklu University, Faculty of Health Sciences, since 2010. I have free radical, antioxidant, anticancer, antitumor, and antimicrobial studies.

    • Abela AR, Browne CJ, Sargin D, Prevot TD, Ji XD, Li Z, Lambe EK, Fletcher PJ (2020) Median raphe serotonin neurons promote anxiety-like behavior via inputs to the dorsal hippocampus. Neuropharmacology 15(168):107985

    • Bamalan, O. A., Moore, M. J., & Al Khalili, Y. (2019). Physiology, serotonin. Europe PMC

    • Bakshi, A., & Tadi, P. (2020). Biochemistry, serotonin. Europe PMC.

    • Berger, M., Gray, J. A., & Roth, B. L. (2009). The expanded biology of serotonin. Annual review of medicine, 60, 355-366.

    • Brown, S. L., Bleich, A., & Van Praag, H. M. (2023). The monoamine hypothesis of depression: The case for serotonin. In Role of Serotonin in Psychiatric Disorders (pp. 91-128). Routledge.

    • Crispino, M., Volpicelli, F., & Perrone-Capano, C. (2020). Role of the serotonin receptor 7 in brain plasticity: From development to disease. International journal of molecular sciences, 21(2), 505.

    • Dalva, M. B., McClelland, A. C., & Kayser, M. S. (2007). Cell adhesion molecules: signalling functions at the synapse. Nature Reviews Neuroscience, 8(3), 206-220.

    • Decimo, I., Bifari, F., Krampera, M., & Fumagalli, G. (2012). Neural stem cell niches in health and diseases. Current pharmaceutical design, 18(13), 1755-1783.

    • Demarin, V., & Morović, S. (2014). Neuroplasticity. Periodicum biologorum, 116(2), 209-211.

    • Dorszewska, J., Florczak-Wyspianska, J., Kowalska, M., Stanski, M., Kowalewska, A., & Kozubski, W. (2017). Serotonin in neurological diseases. Serotonin: A chemical messenger between all types of living cells, 219

    • Duman RS, Monteggia LM (2006) A neurotrophic model for stress-related mood disorders. Biol Psychiatry 59:1116–1127.

    • Hensler, J. G. (2010). Serotonin in mood and emotion. In Handbook of behavioral neuroscience (Vol. 21, pp. 367-378). Elsevier.

    • Hoyer D, Clarke DE, Fozard JR, et al. International union of pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin). Pharmacol Rev 1994; 46(2): 157-203.

    • Eggers AE (2013) A serotonin hypothesis of schizophrenia. Med Hypotheses 80:791–794

    • Fakhoury, M. (2016). Revisiting the serotonin hypothesis: implications for major depressive disorders. Molecular neurobiology, 53, 2778-2786

    • Fidalgo, S., Ivanov, D. K., & Wood, S. H. (2013). Serotonin: from top to bottom. Biogerontology, 14, 21-45

    • Frick, A., Åhs, F., Engman, J., Jonasson, M., Alaie, I., Björkstrand, J., ... & Furmark, T. (2015). Serotonin synthesis and reuptake in social anxiety disorder: a positron emission tomography study. JAMA psychiatry, 72(8), 794-802.

    • Forster, G. L., Novick, A. M., Scholl, J. L., & Watt, M. J. (2012). The role of the amygdala in anxiety disorders. The amygdala-a discrete multitasking manager, 61-102

    • Ivetic, N., Arnold, D. M., Smith, J. W., Huynh, A., Kelton, J. G., & Nazy, I. (2019). A platelet viability assay (PVA) for the diagnosis of heparin-induced thrombocytopenia. Platelets, 30(8), 1017-1021

    • Kandel, E., Schwartz, J., & Jessell, T. (2001). Depression, mania and anxiety disorders. Principles of Neural Science. McGraw-Hill, New York,, 1209-1225

    • Kanova, M., & Kohout, P. (2021). Serotonin—Its synthesis and roles in the healthy and the critically ill. International journal of molecular sciences, 22(9), 4837

    • Karamustafalıoğlu, O., & Yumrukçal, H. (2011). Depresyon ve anksiyete bozuklukları. Şişli Etfal Hastanesi Tıp Bülteni, 45(2), 65-74

    • Kayabaşı, Y., Güneş, B., & Erbaş, O. (2021). Serotonin receptors and depression. Journal of Experimental and Basic Medical Sciences, 2(2), 240-246

    • Kapur, S., & Remington, G. (1996). Serotonin-dopamine interaction and its relevance to schizophrenia. American Journal of Psychiatry, 153(4), 466-476

    • Kepser, L. J., & Homberg, J. R. (2015). The neurodevelopmental effects of serotonin: a behavioural perspective. Behavioural brain research, 277, 3-13

    • Lam, D. D., Garfield, A. S., Marston, O. J., Shaw, J., & Heisler, L. K. (2010). Brain serotonin system in the coordination of food intake and body weight. Pharmacology Biochemistry and Behavior, 97(1), 84-91

    • Lee, A., Choo, H., & Jeon, B. (2022). Serotonin receptors as therapeutic targets for autism spectrum disorder treatment. International Journal of Molecular Sciences, 23(12), 6515

    • Lv, J., & Liu, F. (2017). The role of serotonin beyond the central nervous system during embryogenesis. Frontiers in cellular neuroscience, 11, 74

    • Mitroshina, E. V., Marasanova, E. A., & Vedunova, M. V. (2023). Functional Dimerization of Serotonin Receptors: Role in Health and Depressive Disorders. International Journal of Molecular Sciences, 24(22), 16416

    • Mohammad‐Zadeh, L. F., Moses, L., & Gwaltney‐Brant, S. M. (2008). Serotonin: a review. Journal of veterinary pharmacology and therapeutics, 31(3), 187-199

    • Moncrieff, J., Cooper, R. E., Stockmann, T., Amendola, S., Hengartner, M. P., & Horowitz, M. A. (2023). The serotonin theory of depression: a systematic umbrella review of the evidence. Molecular psychiatry, 28(8), 3243-3256

    • Mück-Šeler, D. O. R. O. T. E. A., & Pivac, N. (2011). Serotonin. Periodicum Biologorum, 113(1), 29-41

    • Naeem, M., Chadeayne, A. R., Golen, J. A., & Manke, D. R. (2022). Crystal structure of serotonin. Acta Crystallographica Section E: Crystallographic Communications, 78(4), 365-368

    • Naughton, M., Mulrooney, J. B., & Leonard, B. E. (2000). A review of the role of serotonin receptors in psychiatric disorders. Human Psychopharmacology: Clinical and Experimental, 15(6), 397-415.

    • Olivier, B. (2015). Serotonin: a never-ending story. European journal of pharmacology, 753, 2-18

    • Quednow, B. B., Geyer, M. A., & Halberstadt, A. L. (2010). Serotonin and schizophrenia. In Handbook of Behavioral Neuroscience (Vol. 21, pp. 585-620). Elsevier.

    • Parajulee, A., & Kim, K. (2023). Structural studies of serotonin receptor family. BMB reports, 56(10), 527.

    • Pourhamzeh, M., Moravej, F. G., Arabi, M., Shahriari, E., Mehrabi, S., Ward, R., ... & Joghataei, M. T. (2022). The roles of serotonin in neuropsychiatric disorders. Cellular and molecular neurobiology, 42(6), 1671-1692.

    • Ruddell, R. G., Mann, D. A., & Ramm, G. A. (2008). The function of serotonin within the liver. Journal of hepatology, 48(4), 666-675.

    • Stein, M. B., & Andrews, A. M. (2015). Serotonin states and social anxiety. JAMA psychiatry, 72(8), 845-847.

    • Tan, D. X., Manchester, L. C., Esteban-Zubero, E., Zhou, Z., & Reiter, R. J. (2015). Melatonin as a potent and inducible endogenous antioxidant: synthesis and metabolism. Molecules, 20(10), 18886-18906.

    • Thibaut, F. (2017). Anxiety disorders: a review of current literature. Dialogues in clinical neuroscience, 19(2), 87-88.

    • Uddin, L. Q. (2021). Cognitive and behavioural flexibility: neural mechanisms and clinical considerations. Nature Reviews Neuroscience, 22(3), 167-179.

    • Yano, J. M., Yu, K., Donaldson, G. P., Shastri, G. G., Ann, P., Ma, L., ... & Hsiao, E. Y. (2015). Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis. Cell, 161(2), 264-276.

    • Wirth, A., Holst, K., & Ponimaskin, E. (2017). How serotonin receptors regulate morphogenic signalling in neurons. Progress in neurobiology, 151, 35-56.

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