Release Date: 2024-06-07

Natural Antioxidant Inhibitors: in Vitro Evaluation of Anti-Epileptic, Anti-Alzheimer’s Disease and Anti-Diabetic Agents (2015-Present)

Arslan Recep Sahin (Author), Nastaran Sadeghian (Author), Parham Taslimi (Author)

Release Date: 2024-06-07

Natural antioxidant inhibitors act as precursors in the treatment of many metabolic diseases. Natural antioxidant inhibitors are especially important in the treatment of metabolic diseases such as Epilepsy, Diabetes and Alzheimer’s. Therefore, in this chapter, natural antioxidant inhibitors and their effects on metabolic diseases are explained with current scientific studies. It is anticipated that this [...]

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    Work TypeBook Chapter
    Published inNatural Antioxidants and in Vitro Antioxidant Assays
    First Page43
    Last Page70
    DOIhttps://doi.org/10.69860/nobel.9786053359333.3
    Page Count28
    Copyright HolderNobel Tıp Kitabevleri
    Licensehttps://nobelpub.com/publish-with-us/copyright-and-licensing

    Natural antioxidant inhibitors act as precursors in the treatment of many metabolic diseases. Natural antioxidant inhibitors are especially important in the treatment of metabolic diseases such as Epilepsy, Diabetes and Alzheimer’s. Therefore, in this chapter, natural antioxidant inhibitors and their effects on metabolic diseases are explained with current scientific studies. It is anticipated that this study will be a reference for many scientific studies.

    Nastaran Sadeghian (Author)
    PhD, Asst. Prof. Dr., Bartin University
    https://orcid.org/0000-0002-2913-4614
    3The author graduated from Islamic Azad University, Faculty of Science in 2009, which started in 2005. In 2012, he completed his master’s degree in the anorganic chemistry at the same university, with a thesis subject "Synthesis of nanomagnetic." He graduated his doctorate at Ataturk University, Faculty of Science, in the Biochemistry program.astaran SADEGHIAN focused on the basic and current issues of biochemistry in her academic studies. Her most important studies are related to the antioxidant activities of molecules and herbal extracts obtained from natural sources or through synthesis. These studies were published in journals with a very high impact factor. In addition to candidate antioxidant activity studies, She also conducts studies on the purification and characterization of some metabolic enzymes and the design and synthesis of inhibitors for these enzymes. In this very current field, carbonic anhydrase isoenzymes, which are associated with disorders such as glaucoma, cancer, epilepsy, ulcer and osteoporosis, acetylcholinesterase and butyrylcholinesterase enzymes, which have an important place in the cholinergic hypothesis and are associated with many neurodegenerative diseases such as Alzheimer’s disease, and α-glucosidase, which is associated with diabetes. He carries out studies on the purification and characterization of digestive enzymes such as and α-amylase, and the design and synthesis of new inhibitors for these enzymes. He made up-to-date approaches on druggability properties by supporting the inhibition types and mechanisms of action of molecules with known inhibition properties on these candidate enzymes with molecular modeling (docking) studies.

    Arslan Recep Sahin (Author)
    MD, Bartin University
    https://orcid.org/0000-0001-5593-6795
    3The author graduated from Bartın University from Department of Biotechnology.He focused on the basic and current issues of biochemistry in his academic studies. His most important studies are related to the antioxidant activities of molecules and herbal extracts obtained from natural sources or through synthesis.

    Parham Taslimi (Author)
    PhD, Assoc. Prof. Dr., Bartin University
    https://orcid.org/0000-0002-3171-0633
    3The author graduated from Islamic Azad University, Faculty of Science in 2010, which started in 2006. In 2013, he completed his master’s degree in the Molecular Biology and Genetics at the Ataturk university, with a thesis subject "Termostable enzyme" He graduated his doctorate at Ataturk University, Faculty of Science, in the Biochemistry program.Parham TASLIMI focused on the basic and current issues of biochemistry in his academic studies. His most important studies are related to the antioxidant activities of molecules and herbal extracts obtained from natural sources or through synthesis. These studies were published in journals with a very high impact factor. In addition to candidate antioxidant activity studies, he also conducts studies on the purification and characterization of some metabolic enzymes and the design and synthesis of inhibitors for these enzymes. In this very current field, carbonic anhydrase isoenzymes, which are associated with disorders such as glaucoma, cancer, epilepsy, ulcer and osteoporosis, acetylcholinesterase and butyrylcholinesterase enzymes, which have an important place in the cholinergic hypothesis and are associated with many neurodegenerative diseases such as Alzheimer’s disease, and α-glucosidase, which is associated with diabetes. He carries out studies on the purification and characterization of digestive enzymes such as and α-amylase, and the design and synthesis of new inhibitors for these enzymes. He made up-to-date approaches on druggability properties by supporting the inhibition types and mechanisms of action of molecules with known inhibition properties on these candidate enzymes with molecular modeling (docking) studies.

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