The treatment of metastatic prostate cancer contains various options. Hormonal agents, chemotherapies, targeted therapies and bone modifying agents are used in different combination and sequence nowadays. In this chapter, the importance of sequencing these treatments is depicted. Because of the numerous factors affecting the clinician’s decision making process, there is a need to simplify the treatment algorithms. Our aim is to spotlight on current treatments thanks to the evidence based data. Since there is rapid progress in randomized clinical trials and increasing body of evidence, one should keep in mind that following the latest guidelines will be the best approach to this topic. We hope our effort may help clinicians in their everyday practice.