Release Date: 2024-06-10

Effects of Turmeric in Neurological Diseases

Abdurrahman Abakay (Author)

Release Date: 2024-06-10

Zingiberaceae is a large and diverse family of plants commonly known as the “Gingeraceae”. The Zingiberaceae family is a plant family known for its plant diversity, economic importance, and potential for medicinal use. Turmeric is a perennial, rhizomatous, herbaceous plant from the ginger family, containing the compound curcumin and offering many health benefits Cardamom, turmeric, [...]

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    Work TypeBook Chapter
    Published inNeurological Diseases and Treatments in Terms of Biochemistry
    First Page111
    Last Page124
    DOIhttps://doi.org/10.69860/nobel.9786053359357.7
    Page Count14
    Copyright HolderNobel Tıp Kitabevleri
    Licensehttps://nobelpub.com/publish-with-us/copyright-and-licensing

    Zingiberaceae is a large and diverse family of plants commonly known as the “Gingeraceae”. The Zingiberaceae family is a plant family known for its plant diversity, economic importance, and potential for medicinal use. Turmeric is a perennial, rhizomatous, herbaceous plant from the ginger family, containing the compound curcumin and offering many health benefits Cardamom, turmeric, and ginger are among the bioactive chemicals having antioxidant action that belong to the Zingiberaceae family. In addition, they possess anti-inflammatory, antibacterial, anticancer, and antiemetic characteristics, which aid in the prevention of neurological and cardiovascular illnesses. Supplementing with turmeric can be a useful intervention for improving people’s oxidative/inflammatory condition.

    Abdurrahman Abakay (Author)
    PhD, Assoc. Prof. Dr., Private Diyarlife Hospital
    https://orcid.org/0009-0005-2283-2777
    3The author is a pulmonologist. The author’s special interest is functional medicine and functional foods.

    • Ballester P, Cerdá B, Arcusa R, García-Muñoz AM, Marhuenda J, Zafrilla P. Antioxidant Activity in Extracts from Zingiberaceae Family: Cardamom, Turmeric, and Ginger. Molecules. 2023;28(10):4024.

    • Kunnumakkara, A.B.; Bordoloi, D.; Padmavathi, G.; Monisha, J.; Roy, N.K.; Prasad, S.; Aggarwal, B.B. Curcumin, the golden nutraceutical: Multitargeting for multiple chronic diseases. Br. J. Pharmacol. 2017, 174, 1325–1348.

    • Kocaadam, B.; ¸Sanlier, N. Curcumin, an active component of turmeric (Curcuma longa), and its effects on health. Crit. Rev. Food Sci. Nutr. 2017, 57, 2889–2895.

    • Nair, A.; Amalraj, A.; Jacob, J.; Kunnumakkara, A.B.; Gopi, S. Non-Curcuminoids from Turmeric and Their Potential in CancerTherapy and Anticancer Drug Delivery Formulations. Biomolecules 2019, 9, 13.

    • Aggarwal, B.B.; Yuan, W.; Li, S.; Gupta, S.C. Curcumin-free turmeric exhibits anti-inflammatory and anticancer activities:Identification of novel components of turmeric. Mol. Nutr. Food Res. 2013, 57, 1529–1542.

    • Abrahams, S.; Haylett, W.L.; Johnson, G.; Carr, J.A.; Bardien, S. Antioxidant effects of curcumin in models of neurodegeneration,aging, oxidative and nitrosative stress: A review. Neuroscience 2019, 406, 1–21.

    • Garza, G.R.C.; Luévano, J.H.E.; Rodríguez, A.F.B.; Montes, A.C.; Hernández, R.A.P.; Delgado, A.J.M.; Villarreal, S.M.L.; Rodríguez,J.R.; Casas, R.M.S.; Velázquez, U.C.; et al. Benefits of Cardamom (Elettaria cardamomum (L.) Maton) and Turmeric (Curcuma longa L.)Extracts for Their Applications as Natural Anti-Inflammatory Adjuvants. Plants 2021, 10, 1908.

    • Zhang, H.A.; Kitts, D.D. Turmeric and its bioactive constituents trigger cell signaling mechanisms that protect against diabetesand cardiovascular diseases. Mol. Cell. Biochem. 2021, 476, 3785–3814.

    • Ming, T.; Tao, Q.; Tang, S.; Zhao, H.; Yang, H.; Liu, M.; Ren, S.; Xu, H. Curcumin: An epigenetic regulator and its application incancer. Biomed. Pharmacother. 2022, 156, 113956.

    • Gupta, N.; Verma, K.; Nalla, S.; Kulshreshtha, A.; Lall, R.; Prasad, S. Free Radicals as a Double-Edged Sword: The CancerPreventive and Therapeutic Roles of Curcumin. Molecules 2020, 25, 5390.

    • Jabczyk, M.; Nowak, J.; Hudzik, B.; Zubelewicz-Szkodzi´ nska, B. Curcumin in Metabolic Health and Disease. Nutrients 2021,13, 4440.

    • Jiang, T.A. Health Benefits of Culinary Herbs and Spices. J. AOAC Int. 2019, 102, 395–411.

    • Li, R.; Wang, Y.; Liu, Y.; Chen, Q.; Fu, W.; Wang, H.; Cai, H.; Peng, W.; Zhang, X. Curcumin Inhibits Transforming GrowthFactor-1-Induced EMT via PPAR Pathway, Not Smad Pathway in Renal Tubular Epithelial Cells. PLoS ONE 2013, 8, e58848.

    • Zhang, S.; Dimango, E.; Zhu, Y.; Saroya, T.K.; Emala, C.W.; Sang, S. Pharmacokinetics of Gingerols, Shogaols, and TheirMetabolites in Asthma Patients. J. Agric. Food Chem. 2022, 70, 9674–9683.

    • Racz, L.Z.; Racz, C.P.; Pop, L.C.; Tomoaia, G.; Mocanu, A.; Barbu, I.; Sárközi, M.; Roman, I.; Avram, A.; Tomoaia-Cotisel, M.; et al. Strategies for Improving Bioavailability, Bioactivity, and Physical-Chemical Behavior of Curcumin. Molecules 2022, 27, 6854.

    • Bi, X.; Yuan, Z.; Qu, B.; Zhou, H.; Liu, Z.; Xie, Y. Piperine enhances the bioavailability of silybin via inhibition of efflux transportersBCRP and MRP2. Phytomedicine 2019, 54, 98–108.

    • Sohn, S.-I.; Priya, A.; Balasubramaniam, B.; Muthuramalingam, P.; Sivasankar, C.; Selvaraj, A.; Valliammai, A.; Jothi, R.; Pandian,S. Biomedical Applications and Bioavailability of Curcumin-An Updated Overview. Pharmaceutics 2021, 13, 2102.

    • Scalbert, A.; Manach, C.; Morand, C.; Rémésy, C.; Jiménez, L. Dietary polyphenols and the prevention of diseases. Crit. Rev. FoodSci. Nutr. 2005, 45, 287–306.

    • Dˇ uracˇková, Z. Some current insights into oxidative stress. Physiol. Res. 2010, 59, 459–469.

    • Sies, H.; Berndt, C.; Jones, D.P. Oxidative Stress. Annu. Rev. Biochem. 2017, 86, 715–748.

    • Hussain, T.; Tan, B.; Yin, Y.; Blachier, F.; Tossou, M.C.B.; Rahu, N. Oxidative Stress and Inflammation: What Polyphenols Can Dofor Us? Oxid. Med. Cell. Longev. 2016, 2016, 7432797.

    • Del Río, L.A. ROS and RNS in plant physiology: An overview. J. Exp. Bot. 2015, 66, 2827–2837.

    • Giles, G.I.; Tasker, K.M.; Jacob, C. Hypothesis: The role of reactive sulfur species in oxidative stress. Free Radic. Biol. Med. 2001, 31,1279–1283.

    • DeLeon, E.R.; Gao, Y.; Huang, E.; Arif, M.; Arora, N.; Divietro, A.; Patel, S.; Olson, K.R. A case of mistaken identity: Are reactive oxygen species actually reactive sulfide species? Am. J. Physiol. Regul. Integr. Comp. Physiol. 2016, 310, R549–R560.

    • Labunskyy, V.M.; Hatfield, D.L.; Gladyshev, V.N. Selenoproteins: Molecular pathways and physiological roles. Physiol. Rev. 2014,94, 739–777.

    • Lobo, V.; Patil, A.; Phatak, A.; Chandra, N. Free radicals, antioxidants and functional foods: Impact on human health. Pharmacogn Rev. 2010, 4, 118–126.

    • Alkadi, H. A Review on Free Radicals and Antioxidants. Infect. Disord. Drug Targets 2020, 20, 16–26.

    • Von Dentz, K.E.; Silva, B.S.; Queiroz, E.A.I.F.; Bomfim, G.F.; Nascimento, A.F.; Sugizaki, M.M.; Luvizotto, R.A.M. Hibiscussabdariffa ethanolic extract modulates adipokine levels, decreases visceral fat and improves glycemic profile in high-fat/sugardiet-induced obese rats. Nutr. Food Sci. 2021, 51, 222–233.

    • Rahal, A.; Kumar, A.; Singh, V.; Yadav, B.; Tiwari, R.; Chakraborty, S.; Dhama, K. Oxidative stress, prooxidants, and antioxidants:The interplay. Biomed. Res. Int. 2014, 2014, 761264.

    • Gaschler, M.M.; Stockwell, B.R. Lipid peroxidation in cell death. Biochem. Biophys. Res. Commun. 2017, 482, 419–425.

    • Tan, B.L.; Norhaizan, M.E.; Liew, W.P.P.; Rahman, H.S. Antioxidant and oxidative stress: A mutual interplay in age-relateddiseases. Front. Pharmacol. 2018, 9, 1162.

    • Espinosa-Diez, C.; Miguel, V.; Mennerich, D.; Kietzmann, T.; Sánchez-Pérez, P.; Cadenas, S.; Lamas, S. Antioxidant responses andcellular adjustments to oxidative stress. Redox Biol. 2015, 6, 183–197.

    • Jakubczyk, K.; Druz˙ga, A.; Katarzyna, J.; Skonieczna-Z˙ ydecka, K. Antioxidant Potential of Curcumin-A Meta-Analysis ofRandomized Clinical Trials. Antioxidants 2020, 9, 1092.

    • Alizadeh, M.; Kheirouri, S. Curcumin reduces malondialdehyde and improves antioxidants in humans with diseased conditions:A comprehensive meta-analysis of randomized controlled trials. BioMedicine 2019, 9, 23.

    • Lai, L.; Yan, L.; Gao, S.; Hu, C.L.; Ge, H.; Davidow, A.; Park, M.; Bravo, C.; Iwatsubo, K.; Ishikawa, Y.; et al. Type 5 adenylyl cyclaseincreases oxidative stress by transcriptional regulation of manganese superoxide dismutase via the SIRT1/FoxO3a pathway.Circulation 2013, 127, 1692–1701.

    • Qiu, X.; Brown, K.; Hirschey, M.D.; Verdin, E.; Chen, D. Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2activation. Cell Metab. 2010, 12, 662–667.

    • Dehzad, M.J.; Ghalandari, H.; Nouri, M.; Askarpour, M. Antioxidant and anti-inflammatory effects of curcumin/turmericsupplementation in adults: A GRADE-assessed systematic review and dose–response meta-analysis of randomized controlledtrials. Cytokine 2023, 164, 156144.

    • Panahi, Y.; Hosseini, M.S.; Khalili, N.; Naimi, E.; Majeed, M.; Sahebkar, A. Antioxidant and anti-inflammatory effects ofcurcuminoid-piperine combination in subjects with metabolic syndrome: A randomized controlled trial and an updated metaanalysis.Clin. Nutr. 2015, 34, 1101–1108.

    • Halliwell, B. Role of free radicals in the neurodegenerative diseases: Therapeutic implications for antioxidant treatment. Drugs Aging 2001, 18, 685–716.

    • Spagnuolo, C.; Napolitano, M.; Tedesco, I.; Moccia, S.; Milito, A.; Russo, G.L. Neuroprotective Role of Natural Polyphenols. Curr.Top. Med. Chem. 2016, 16, 1943–1950.

    • Tang, M.; Taghibiglou, C. The Mechanisms of Action of Curcumin in Alzheimer’s Disease. J. Alzheimers. Dis. 2017, 58, 1003–1016.

    • Belwal, T.; Nabavi, S.M.; Nabavi, S.F.; Dehpour, A.R.; Shirooie, S. Naturally Occurring Chemicals against Alzheimer’s Disease;Academic Press: Cambridge, MA, USA, 2020; ISBN 0128192135.

    • Angelopoulou, E.; Paudel, Y.N.; Papageorgiou, S.G.; Piperi, C. Elucidating the Beneficial Effects of Ginger (Zingiber officinale Roscoe) in Parkinson’s Disease. ACS Pharmacol. Transl. Sci. 2022, 5, 838–848.

    • Reddy, P.H.; Manczak, M.; Yin, X.; Grady, M.C.; Mitchell, A.; Tonk, S.; Kuruva, C.S.; Bhatti, J.S.; Kandimalla, R.; Vijayan, M.; et al.Protective Effects of Indian Spice Curcumin Against Amyloid in Alzheimer’s Disease. J. Alzheimers. Dis. 2018, 61, 843–866.

    • Moon, M.; Kim, H.G.; Choi, J.G.; Oh, H.; Lee, P.K.; Ha, S.K.; Kim, S.Y.; Park, Y.; Huh, Y.; Oh, M.S. 6-Shogaol, an active constituentof ginger, attenuates neuroinflammation and cognitive deficits in animal models of dementia. Biochem. Biophys. Res. Commun.2014, 449, 8–13.

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